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1. Therapeutic potential of caffeic acid phenethyl ester (CAPE) in diabetes
by Pittalà, Valeria and Salerno, Loredana and Romeo, Giuseppe and Acquaviva, Rosaria and Di Giacomo, Claudia and Sorrenti, Valeria
Current Medicinal Chemistry, ISSN 0929-8673, 2018, Volume 25, Issue 37, pp. 4827 - 4836
Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the... 
Oxidative stress | Nrf2 | Caffeic acid phenethyl ester | Polyphenols | Inflammation | Diabetes | Diabetes induced complications | Retinopathy | Free radicals | Stability | Complications | Immunomodulation | Diabetes mellitus | Propolis | Neuropathy | Caffeic acid | Anticancer properties | Antioxidants | Hyperglycemia | Molecular modelling | Nephropathy | Acids | Etiology | Antitumor activity | Sugar | Metabolic disorders
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2. Full Text Protective effects of caffeic acid phenethyl ester (Cape) and novel cape analogue as inducers of heme oxygenase-1 in streptozotocin-induced type 1 diabetic rats
by Sorrenti, Valeria and Raffaele, Marco and Vanella, Luca and Acquaviva, Rosaria and Salerno, Loredana and Pittalà, Valeria and Intagliata, Sebastiano and Di Giacomo, Claudia
International Journal of Molecular Sciences, ISSN 1661-6596, 05/2019, Volume 20, Issue 10, p. 2441
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease resulting in the destruction of insulin producing -cells of the pancreas, with consequent... 
Inducible nitric oxide synthase (iNOS) | Pancreatic oxidative damage | Reactive oxygen species (ROS) | Caffeic acid phenethyl ester (CAPE) | Gamma-Glutamyl-Cysteine Ligase (GGCL) | Type 1 diabetes mellitus (T1D) | Heme oxygenase-1 (HO-1) inducers | Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) | OXIDATIVE STRESS | LIPID-PEROXIDATION | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ASYMMETRIC DIMETHYLARGININE | ANTIOXIDANT ENZYMES | HUMAN-ENDOTHELIAL-CELLS | CYANIDIN 3-O-BETA-D-GLUCOSIDE | Caffeic acid phenethyl ester (CAPE) | CHEMISTRY, MULTIDISCIPLINARY | GLUCOSE | LIVER | GENE-EXPRESSION
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3. Full Text Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells
by Malfa, Giuseppe Antonio and Tomasello, Barbara and Acquaviva, Rosaria and Genovese, Carlo and La Mantia, Alfonsina and Cammarata, Francesco Paolo and Ragusa, Monica and Renis, Marcella and Di Giacomo, Claudia
International journal of molecular sciences, ISSN 1422-0067, 06/2019, Volume 20, Issue 11, p. 2723
Betula etnensis Raf. (Birch Etna) belonging to the Betulaceae family grows on the eastern slope of Etna. Many bioactive compounds present in Betula species are... 
Colon cancer | ferroptosis | heme oxigenase-1 | thiol groups | Betula etnensis Raf | oxidative stress | SYSTEM | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | CHEMISTRY, MULTIDISCIPLINARY | DIET | GROWTH | GENERATION | HEME OXYGENASE-1 | Colorectal cancer | Bark | Cytotoxicity | Raf protein | Lipids | Neuroblastoma | Cancer therapies | Anticancer properties | Antioxidants | Antitumor agents | Bioactive compounds | Cell cycle | Heme | Polyphenols | Colon | Drug dosages | Heme oxygenase (decyclizing) | Oxygenase | Cell death | Protein expression | Annexin V | Prostate | Viability | Apoptosis
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4. Full Text Caffeic Acid Phenethyl Ester Regulates PPAR's Levels in Stem Cells-Derived Adipocytes
by Vanella, Luca and Tibullo, Daniele and Godos, Justyna and Pluchinotta, Francesca Romana and Di Giacomo, Claudia and Sorrenti, Valeria and Acquaviva, Rosaria and Russo, Alessandra and Li Volti, Giovanni and Barbagallo, Ignazio
PPAR Research, ISSN 1687-4757, 2016, Volume 2016, p. 7359521
Hypertrophic obesity inhibits activation of peroxisome proliferators-activated receptor gamma (PPAR gamma), considered the key mediator of the fully... 
MEDICINE, RESEARCH & EXPERIMENTAL | METABOLIC SYNDROME | OBESITY | GENE | INSULIN-RESISTANCE | INFLAMMATION | ALPHA | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | ADIPOSE-TISSUE | Phenols | Fat cells | Cell receptors | Health aspects | Enzymes | Obesity | Transcription factors | Cytokines | Colleges & universities | Lipids | Triglycerides | Inflammation | Adipocytes | Insulin | Fatty acids | Proteins | Rodents | Stem cells | Gangrene | Insulin resistance | Tumor necrosis factor-TNF | Oxidation | Growth factors | Metabolic disorders
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5. Full Text Identification of an ERK Inhibitor as a Therapeutic Drug Against Tau Aggregation in a New Cell-Based Assay
by Siano, G and Caiazza, MC and Olla, I and Varisco, M and Madaro, G and Quercioli, V and Calvello, M and Cattaneo, A and Di Primio, C
FRONTIERS IN CELLULAR NEUROSCIENCE, ISSN 1662-5102, 08/2019, Volume 13, p. 386
Formation of Tau aggregates is a common pathological feature of tauopathies and their accumulation directly correlates with cytotoxicity and neuronal... 
GFP COMPLEMENTATION ASSAY | ACTIVATION | QUANTITATIVE MEASUREMENT | PROTEIN | CST | PHOSPHORYLATION | ALZHEIMERS-DISEASE | Tau | Tau biosensor | aggregation | KINASE INHIBITOR | NEUROSCIENCES | COLOCALIZATION | FRET | ERK
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6. Full Text Antioxidant activity and phenolic content of microwave-assisted Solanum melongena extracts
by Salerno, Loredana and Modica, Maria N and Pittalà, Valeria and Romeo, Giuseppe and Siracusa, Maria A and Di Giacomo, Claudia and Sorrenti, Valeria and Acquaviva, Rosaria
The Scientific World Journal, ISSN 1537-744X, 2014, Volume 2014, p. 719486
Eggplant fruit is a very rich source of polyphenol compounds endowed with antioxidant properties. The aim of this study was to extract polyphenols from... 
AQUEOUS EXTRACT | TEA | HUMAN-DISEASE | INHIBITION | NASUNIN | ANTHOCYANIN | MULTIDISCIPLINARY SCIENCES | EGGPLANT | FLAVONOIDS | FREE-RADICALS | Plant Extracts - chemistry | Phenols - chemistry | Solanum melongena - chemistry | Antioxidants - pharmacology | Plant Extracts - pharmacology | Microwaves | Antioxidants | Eggplant | Phenols | Nutritional aspects | Health aspects | Materia medica, Vegetable | Plant extracts | Oxidative stress | Solvent extraction processes | Vegetables | Free radicals | Ethanol | Polyphenols | Lipid peroxidation | Lipids | Fruits
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7. Full Text Anti-adipogenic and anti-oxidant effects of a standardised extract of Moro blood oranges (Citrus sinensis (L.) Osbeck) during adipocyte differentiation of 3T3-L1 preadipocytes
by Tomasello, Barbara and Malfa, Giuseppe Antonio and La Mantia, Alfonsina and Miceli, Natalizia and Sferrazzo, Giuseppe and Taviano, Maria Fernanda and Di Giacomo, Claudia and Renis, Marcella and Acquaviva, Rosaria
Natural Product Research, ISSN 1478-6419, 09/2019, pp. 1 - 8
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8. Effects of polyphenolic derivatives on heme oxygenase-system in metabolic dysfunctions
by Pittala, Valeria and Vanella, Luca and Salerno, Loredana and Romeo, Giuseppe and Marrazzo, Agostino and Di Giacomo, Claudia and Sorrenti, Valeria
Current Medicinal Chemistry, ISSN 0929-8673, 01/2018, Volume 25, Issue 13, pp. 1577 - 1595
Background: The aim of this review is to summarize the effects of various naturally occurring polyphenols in the management of metabolic dysfunctions. This... 
Oxidative stress | NAFLD | Nrf2 | Polyphenols | HO-1 | Diabetes | Metabolic syndrome | NASH | IMPROVES INSULIN SENSITIVITY | CHEMISTRY, MEDICINAL | HIGH-FAT DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACID PHENETHYL ESTER | INDUCED ENDOTHELIAL DYSFUNCTION | metabolic syndrome | CAFFEIC ACID | CARBON-MONOXIDE | PURIFIED SOY ISOFLAVONES | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | diabetes | NF-KAPPA-B | oxidative stress | Heme Oxygenase-1 - metabolism | Reactive Oxygen Species - metabolism | Cardiovascular Diseases - metabolism | Oxidation-Reduction | Cardiovascular Diseases - drug therapy | Humans | Enzyme Induction | Metabolic Diseases - drug therapy | Metabolic Syndrome - metabolism | Metabolic Syndrome - drug therapy | Antioxidants - therapeutic use | Animals | Metabolic Diseases - metabolism | NF-E2-Related Factor 2 - metabolism | Oxidative Stress - drug effects | Polyphenols - therapeutic use | Genistein | Oxidizing agents | Diabetes mellitus (insulin dependent) | Antioxidants | Literature reviews | Hyperglycemia | Oxidants | Heme | Curcumin | Heart diseases | Inducers | Hypertension | Antiinflammatory agents | Complications | Abnormalities | Diabetes mellitus | Health risks | Heme oxygenase (decyclizing) | Pharmacology | Inflammation | Metabolism | Insulin | Fatty acids | Molecular chains | Caffeic acid | Oxygenase | Hypercholesterolemia | Reviews | Molecular modelling | Quercetin | Cardiovascular diseases | Metabolic disorders
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9. Full Text Erratum: Oxidative stress in normal-weight obese syndrome (Obesity 18 (2125-2130) DOI: 10.1038/oby.2010.50)
by Di Renzo, Laura and Galvano, Fabio and Orlandi, Carmine and Bianchi, Alessia and Di Giacomo, Claudia and La Fauci, Luca and Acquaviva, Rosaria and De Lorenzo, Antonino
Obesity, ISSN 1930-7381, 12/2010, Volume 18, Issue 12, p. 2401
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10. Novel caffeic acid phenethyl ester (Cape) analogues as inducers of heme oxygenase-1
by Pittalà, Valeria and Vanella, Luca and Salerno, Loredana and Giacomo, Claudia Di and Acquaviva, Rosaria and Raffaele, Marco and Romeo, Giuseppe and Modica, Maria N and Prezzavento, Orazio and Sorrenti, Valeria
Current Pharmaceutical Design, ISSN 1381-6128, 2017, Volume 23, Issue 18, pp. 2657 - 2664
Background: Heme Oxygenase-1 (HO-1) is a metabolic enzyme strongly involved in processes including cytoprotection, modulation of inflammatory response,... 
VP961 | Caffeic acid phenethyl ester | HO-1 inducers | Human MSCs | Heme oxygenase | ROS | CELLS | ACTIVATION | ANTITUMOR PROPERTIES | HO-1 INHIBITORS | STRUCTURAL-ANALYSIS | INDUCTION | PATHWAY | INFLAMMATION | caffeic acid phenethyl ester | PHARMACOLOGY & PHARMACY | human MSCs | IMIDAZOLE | DERIVATIVES | Cell Survival - drug effects | Heme Oxygenase-1 - biosynthesis | Reactive Oxygen Species - metabolism | Antioxidants - chemistry | Phenylethyl Alcohol - analogs & derivatives | Humans | Oxidative Stress - physiology | Cells, Cultured | Rats | Caffeic Acids - pharmacology | Caffeic Acids - chemistry | Antioxidants - pharmacology | Rats, Sprague-Dawley | Phenylethyl Alcohol - pharmacology | Reactive Oxygen Species - antagonists & inhibitors | Animals | Enzyme Induction - drug effects | Enzyme Induction - physiology | Oxidative Stress - drug effects | Cell Survival - physiology | Phenylethyl Alcohol - chemistry
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11. Full Text Effect of treatment with cyanidin-3-O-ß-D-glucoside on rat ischemic/reperfusion brain damage
by Di Giacomo, Claudia and Acquaviva, Rosaria and Santangelo, Rosa and Sorrenti, Valeria and Vanella, Luca and Li Volti, Giovanni and D'Orazio, Nicolantonio and Vanella, Angelo and Galvano, Fabio
Evidence-based Complementary and Alternative Medicine, ISSN 1741-427X, 2012, Volume 2012
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12. Full Text Evaluation of Imidazole-Based Compounds as Heme Oxygenase-1 Inhibitors
: Imidazole-Based HO-1 Inhibitors
by Sorrenti, Valeria and Guccione, Salvatore and Di Giacomo, Claudia and Modica, Maria N and Pittalà, Valeria and Acquaviva, Rosaria and Basile, Livia and Pappalardo, Morena and Salerno, Loredana
Chemical Biology & Drug Design, ISSN 1747-0277, 12/2012, Volume 80, Issue 6, pp. 876 - 886
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13. Cyanidin induces apoptosis and differentiation in prostate cancer cells
by Sorrenti, Valeria and Vanella, Luca and Acquaviva, Rosaria and Cardile, Venera and Giofrè, Salvatore and Di Giacomo, Claudia
International Journal of Oncology, ISSN 1019-6439, 10/2015, Volume 47, Issue 4, pp. 1303 - 1310
Several natural antioxidants, including anthocyanins, have been reported to have chemotherapeutic activity in vivo and in vitro. The aim of the present study... 
Cyanidin | Cytodifferentiation | Prostate cancer | Apoptosis | NGFR | cytodifferentiation | cyanidin | apoptosis | ANTHOCYANINS | LINES | prostate cancer | INHIBITION | ONCOLOGY | COLOR | GROWTH | BIOLOGICAL EVALUATION | DU-145 | LEUKEMIA | BLOOD | Index Medicus
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14. Full Text Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties
by Salerno, Loredana and Pittalà, Valeria and Romeo, Giuseppe and Modica, Maria N and Siracusa, Maria A and Di Giacomo, Claudia and Acquaviva, Rosaria and Barbagallo, Ignazio and Tibullo, Daniele and Sorrenti, Valeria
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 09/2013, Volume 21, Issue 17, pp. 5145 - 5153
A novel series of aryloxyalkyl derivatives of imidazole and 1,2,4-triazole, – , was designed and synthesized as inhibitors of heme oxygenase-1 (HO-1) and heme... 
1,2,4-Triazole | Imatinib | Antitumor properties | HO-1inhibitors | Imidazole | CHEMISTRY, MEDICINAL | PHOTODYNAMIC THERAPY | CANCER CELLS | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTICANCER TREATMENT | CHRONIC MYELOID-LEUKEMIA | METALLOPORPHYRINS | ZINC PROTOPORPHYRIN | CARBON-MONOXIDE | IN-VIVO | INCREASES RESPONSIVENESS | Heme Oxygenase-1 - metabolism | Triazoles - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Brain - enzymology | Male | Enzyme Inhibitors - chemical synthesis | RNA, Messenger - metabolism | Antineoplastic Agents - toxicity | Heme Oxygenase-1 - genetics | Triazoles - toxicity | Spleen - enzymology | Enzyme Inhibitors - chemistry | Enzyme Inhibitors - toxicity | Triazoles - chemical synthesis | Imidazoles - toxicity | Imidazoles - chemical synthesis | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Heme Oxygenase (Decyclizing) - genetics | Cell Line | Cell Survival - drug effects | Rats | Antineoplastic Agents - chemistry | Heme Oxygenase-1 - antagonists & inhibitors | Rats, Sprague-Dawley | Animals | Cell Cycle Checkpoints - drug effects | Triazoles | Analysis | Heme | Cancer
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15. Full Text Oxidative Stress in Normal-Weight Obese Syndrome
by Renzo, Laura and Galvano, Fabio and Orlandi, Carmine and Bianchi, Alessia and Giacomo, Claudia and Fauci, Luca and Acquaviva, Rosaria and Lorenzo, Antonino
Obesity, ISSN 1930-7381, 11/2010, Volume 18, Issue 11, pp. 2125 - 2130
The normal‐weight obese (NWO) syndrome was identified in women whose body weight (BW) and BMI are normal but whose fat mass (FM) is >30%. In these subjects, an... 
BIOMARKERS | WOMEN | METABOLIC SYNDROME | NUTRITION & DIETETICS | OXIDANT STRESS | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | FAT | MECHANISMS | BODY-COMPOSITION | GENE POLYMORPHISM | ADIPOSE-TISSUE | Body Mass Index | Nitric Oxide - blood | Lipid Metabolism Disorders - blood | Body Weight | Interleukins - blood | Oxidative Stress | Lipid Metabolism Disorders - metabolism | Humans | Tumor Necrosis Factor-alpha - blood | Inflammation Mediators - blood | Reference Values | Lipid Metabolism Disorders - diagnosis | Case-Control Studies | Obesity - metabolism | Adipose Tissue - metabolism | Waist Circumference | Lipid Peroxides - blood | Lipids - blood | Adult | Female | Italy | Adiposity - physiology | Glutathione - blood
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16. Full Text Effects of Tithonia diversifolia (Hemsl.) A. Gray extract on adipocyte differentiation of human mesenchymal stem cells
by Giacomo, Claudia Di and Vanella, Luca and Sorrenti, Valeria and Santangelo, Rosa and Barbagallo, Ignazio and Calabrese, Giovanna and Genovese, Carlo and Mastrojeni, Silvana and Ragusa, Salvatore and Acquaviva, Rosaria
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0122320
Tithonia diversifolia (Hemsl.) A. Gray (Asteraceae) is widely used in traditional medicine. There is increasing interest on the in vivo protective effects of... 
OXIDATIVE STRESS | LIPID-ACCUMULATION | ACTIVATED PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | HYDROGEN-PEROXIDE | HEME OXYGENASE-1 | NF-KAPPA-B | AY DIABETIC MICE | SESQUITERPENE LACTONES | ADIPOSE-TISSUE | Free Radical Scavengers - pharmacology | Cell Survival - drug effects | Plant Extracts - chemistry | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Humans | Mesenchymal Stromal Cells - metabolism | Adipocytes - cytology | Male | Asteraceae - chemistry | Mesenchymal Stromal Cells - cytology | Adipocytes - metabolism | Female | Cell Differentiation | Oxidative Stress - drug effects | Lipid peroxidation | Medicine, Herbal | Medicine, Botanic | Heme | Stem cells | Oxidative stress | Reactive oxygen species | Adenosine | Mesenchyme | Cultures | Plant protection | Adipocytes | Phenolic compounds | Oxygenase | Leaves | Protein kinase | Adenosine kinase | Phenols | Dichloromethane | In vivo methods and tests | Differentiation | Viability | Adipogenesis | Peroxidation
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17. Full Text Novel imidazole derivatives as heme oxygenase-1 (HO-1) and heme oxygenase-2 (HO-2) inhibitors and their cytotoxic activity in human-derived cancer cell lines
by Salerno, Loredana and Pittalà, Valeria and Romeo, Giuseppe and Modica, Maria N and Marrazzo, Agostino and Siracusa, Maria A and Sorrenti, Valeria and Di Giacomo, Claudia and Vanella, Luca and Parayath, Neha N and Greish, Khaled
European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2015, Volume 96, pp. 162 - 172
Heme oxygenase (HO) is a cytoprotective enzyme that can be overexpressed in some pathological conditions, including certain cancers. In this work, novel... 
HO-1 | Inhibitors | Anti-cancer | HO-2 | Heme oxygenase | Anti-proliferative properties | BENZOTHIAZOLE | CHEMISTRY, MEDICINAL | NITRIC-OXIDE SYNTHASE | SURVIVAL FACTOR | PROLIFERATION | IDENTIFICATION | NUCLEAR TRANSLOCATION | CHRONIC MYELOID-LEUKEMIA | IMATINIB | RESISTANCE | EXPRESSION | Cell Survival - drug effects | Heme Oxygenase-1 - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cyclooxygenase Inhibitors - chemistry | Imidazoles - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Heme Oxygenase-1 - antagonists & inhibitors | Cyclooxygenase Inhibitors - pharmacology | Madin Darby Canine Kidney Cells - drug effects | Dose-Response Relationship, Drug | Animals | Cyclooxygenase Inhibitors - chemical synthesis | Dogs | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Imidazoles - chemical synthesis | Tumor Cells, Cultured | Heme Oxygenase (Decyclizing) - antagonists & inhibitors | Heme Oxygenase (Decyclizing) - metabolism | Drug Screening Assays, Antitumor | Isoenzymes | Heme | Cancer | Index Medicus
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