X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (73) 73
Newspaper Article (39) 39
Magazine Article (34) 34
Book / eBook (21) 21
Publication (6) 6
Book Chapter (2) 2
Book Review (2) 2
Dissertation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (22) 22
humans (20) 20
index medicus (15) 15
mice (15) 15
chemistry, medicinal (14) 14
structure-activity relationship (11) 11
chemistry, organic (9) 9
secretion (9) 9
cho cells (8) 8
diabetes (8) 8
glucose (8) 8
male (8) 8
potent (8) 8
rats (8) 8
20th century (7) 7
models, molecular (7) 7
american literature (6) 6
cells (6) 6
cricetinae (6) 6
discovery (6) 6
history and criticism (6) 6
insulin (6) 6
molecular structure (6) 6
receptors, g-protein-coupled - agonists (6) 6
analysis (5) 5
cricetulus (5) 5
exhibitions (5) 5
fatty acids (5) 5
history (5) 5
letter (5) 5
receptors, g-protein-coupled - metabolism (5) 5
acids (4) 4
art, modern (4) 4
binding sites (4) 4
biochemistry & molecular biology (4) 4
cell biology (4) 4
chemokine (4) 4
crystallography, x-ray (4) 4
diabetes mellitus (4) 4
endocrine system (4) 4
gpr120 (4) 4
gpr40 (4) 4
hypoglycemic agents - chemistry (4) 4
identification (4) 4
inhibition (4) 4
mice, inbred c57bl (4) 4
obesity (4) 4
piperidines - chemistry (4) 4
pyrrolidine scaffold (4) 4
receptor (4) 4
research (4) 4
rodents (4) 4
type 2 diabetes (4) 4
21st century (3) 3
adrenergic beta-3 receptor agonists - pharmacology (3) 3
adrenergic beta-3 receptor agonists - therapeutic use (3) 3
allosteric properties (3) 3
amides - chemistry (3) 3
antagonist (3) 3
art (3) 3
binding (3) 3
cattle (3) 3
cells, cultured (3) 3
diabetes mellitus, type 2 - drug therapy (3) 3
disease (3) 3
dose-response relationship, drug (3) 3
drug discovery (3) 3
drug evaluation, preclinical (3) 3
expression (3) 3
ffa1 (3) 3
ffar4 (3) 3
g protein-coupled receptor (3) 3
gerbillinae (3) 3
glucagon (3) 3
gpcr (3) 3
hiv (3) 3
homeostasis (3) 3
hypoglycemic agents - pharmacology (3) 3
insulin resistance (3) 3
insulin-resistance (3) 3
insulin-secretion (3) 3
italy (3) 3
ligands (3) 3
mice, knockout (3) 3
molecular sequence data (3) 3
neurotrophic factor (3) 3
organic chemistry (3) 3
physiological aspects (3) 3
physiology (3) 3
proteins (3) 3
receptors, g-protein-coupled - genetics (3) 3
tak-875 (3) 3
urinary bladder, overactive - drug therapy (3) 3
β3 adrenergic receptor agonist (3) 3
acidic fibroblast growth factor (2) 2
activation (2) 2
adrenergic beta-3 receptor agonists - chemical synthesis (2) 2
adrenergic beta-3 receptor agonists - chemistry (2) 2
adrenergic receptor agonist (2) 2
aedes albopictus (2) 2
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Robarts - Stacks (13) 13
Collection Dvlpm't (Acquisitions) - Closed Orders (3) 3
Thomas Fisher Rare Book - Rare Book (3) 3
UTL at Downsview - May be requested (3) 3
UofT at Scarborough - Stacks (3) 3
Collection Dvlpm't (Acquisitions) - Vendor file (2) 2
Victoria University E.J. Pratt - Reference (2) 2
Art - Library use only (1) 1
Gerstein Science - Reference (1) 1
Music - Reference (1) 1
St. Augustine's Seminary - Reference (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
Trinity College (John W Graham) - Stacks (1) 1
University College (Laidlaw) - Stacks (1) 1
UofT at Mississauga - Stacks (1) 1
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 8, pp. 942 - 947
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2006, Volume 49, Issue 12, pp. 3614 - 3627
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 07/2017, Volume 24, Issue 7, pp. 570 - 577
Journal Article
Molecular Metabolism, ISSN 2212-8778, 01/2015, Volume 4, Issue 1, pp. 3 - 14
Objectives: GPR40 (FFAR1), a clinically proven anti-diabetes target, is a Gq-coupled receptor for long chain fatty acids (LCFA) stimulating insulin secretion... 
G protein-coupled receptor | Biased signaling | Ago-allosteric agonist | Glucagon like peptide 1 (GLP-1) | Long chain fatty acids (LCFAs)
Journal Article
Journal Article
American Journal of Physiology, ISSN 0193-1849, 07/2017, Volume 313, Issue 1, p. E37
G protein-coupled receptor 40 (GPR40) partial agonists lower glucose through the potentiation of glucose-stimulated insulin secretion, which is believed to... 
Potentiation | Obesity | CD26 antigen | Peptidase | Peptides | Glucagon | Secretion | Body weight | Weight loss | Body weight loss | Glucose | Insulin | Body weight gain | Weight | Modulators | Proteins | Allosteric properties | Diet | Food intake | Mice | Diabetes | Glucagon-like peptide 1 | Gastric motility
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2017, Volume 12, Issue 5, p. e0176182
GPR40 (FFA1) is a fatty acid receptor whose activation results in potent glucose lowering and insulinotropic effects in vivo. Several reports illustrate that... 
OBESITY | STIMULATION | GLUCONEOGENESIS | DEPENDENT INSULIN-SECRETION | MULTIDISCIPLINARY SCIENCES | GLYCOGENOLYSIS | PANCREATIC BETA-CELLS | IMPROVES | TAK-875 | TYPE-2 | RECEPTOR 1 AGONIST | Diabetes Mellitus, Experimental - drug therapy | Cricetulus | Rats, Wistar | Receptors, G-Protein-Coupled - metabolism | Humans | Male | Receptors, G-Protein-Coupled - agonists | Thiazolidinediones - chemistry | Insulin - blood | Benzopyrans - chemistry | Liver - drug effects | Time Factors | Fasting - blood | HEK293 Cells | Benzopyrans - pharmacology | Diabetes Mellitus, Experimental - metabolism | Drug Evaluation, Preclinical | Thiazolidinediones - pharmacology | CHO Cells | Tissue Culture Techniques | Liver - metabolism | Rats | Hypoglycemic Agents - chemistry | Hypoglycemic Agents - pharmacology | Mice, Knockout | Blood Glucose - drug effects | Animals | Glucose - metabolism | Receptors, G-Protein-Coupled - genetics | Blood Glucose - metabolism | Type 2 diabetes | Glucose metabolism | Care and treatment | Analysis | Patient outcomes | Dosage and administration | Fatty acids | Health aspects | Insulin | Cell culture | Blasticidin S | Biochemistry | Glucose | Males | Assaying | Temperature effects | Penicillin | Hemoglobin | Inhibition | Pharmaceutical industry | Gluconeogenesis | Obesity | Estrus | Media | Bioavailability | Metabolism | Chemicals | Beta cells | Studies | Dilution | Diet | Biomarkers | Mice | Binding sites | Metabolic disorders | Temperature | Physiological effects | Media (culture) | Nuclear magnetic resonance--NMR | Centrifugation | Medical services | Homeostasis | Clinical trials | Amino acids | Stimulation | Defects | Quinones | Allosteric properties | Farms | Rodents | Fasting | Purification | Secretion | Diabetes mellitus | Pharmacology | Skeletal muscle | Glucose tolerance | Buffers (chemistry) | Musculoskeletal system | Growth media | Reagents | Insulin resistance | In vivo methods and tests | Resonance | Diabetes | Females | Nuclear magnetic resonance | NMR
Journal Article
Journal of Lipid Research, ISSN 0022-2275, 2017, Volume 58, Issue 8, pp. 1561 - 1578
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2016, Volume 59, Issue 2, pp. 609 - 623
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1842 - 1848
GPR40 (FFAR1 or FFA1) is a G protein-coupled receptor, primarily expressed in pancreatic islet β-cells and intestinal enteroendocrine cells. When activated by... 
FFA1 | GPCR | Diabetes | GPR40 AgoPAM | Indane | CELLS | CHEMISTRY, MEDICINAL | EFFICACY | SAFETY | ACIDS | CHEMISTRY, ORGANIC | RECEPTOR 40 AGONIST | FASIGLIFAM TAK-875 | DISCOVERY | POTENT | JAPANESE PATIENTS | Pancreatic beta cells | Analysis | Liver | Glucose | G proteins | Fatty acids | Dextrose | Membrane proteins
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2017, Volume 8, Issue 1, pp. 96 - 101
GPR120 (FFAR4) is a fatty acid sensing G protein coupled receptor (GPCR) that has been identified as a target for possible treatment of type 2 diabetes. A... 
Type 2 diabetes | FFAR4 | Insulin sensitization | Chromane | GPR120 | RECEPTOR GPR120 | CHEMISTRY, MEDICINAL | HIT | type 2 diabetes | INHIBITION | INSULIN-RESISTANCE | insulin sensitization | chromane | SECRETION | BINDING | LIFE
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2016, Volume 26, Issue 23, pp. 5724 - 5728
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2017, Volume 27, Issue 4, pp. 1094 - 1098
The synthesis of a novel class of piperazine benzamide (reverse amides) targeting the human β -adrenergic receptor for the treatment of overactive bladder... 
Overactive bladder | Norepinephrine transporter | β3-Adrenergic receptor agonist | Reverse amide | Pyrrolidine scaffold | Adrenergic receptor agonist
Journal Article