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Nature, ISSN 0028-0836, 2017, Volume 552, Issue 7683, pp. 1 - 5
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2018, Volume 143, Issue 4, pp. 907 - 920
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
Journal Article
Nature Communications, ISSN 2041-1723, 09/2015, Volume 6, Issue 1, pp. 8305 - 8305
Molecular targeted drugs are clinically effective anti-cancer therapies. However, tumours treated with single agents usually develop resistance. Here we use... 
HETEROGENEITY | GEFITINIB | EVOLUTION | MELANOMA | AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | THERAPIES | BRAF | DRUG-RESISTANCE | MUTATIONS | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2015, Volume 21, Issue 7, pp. 795 - 801
Journal Article
Journal Article
JAMA, ISSN 0098-7484, 10/2010, Volume 304, Issue 16, pp. 1812 - 1820
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 08/2010, Volume 120, Issue 8, pp. 2858 - 2866
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 100 - 104
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma(1). However, colon... 
PANITUMUMAB | TARGET | CETUXIMAB | MELANOMA | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CARCINOMA | KRAS | METASTATIC COLORECTAL-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - agonists | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cetuximab | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Colorectal Neoplasms - enzymology | Antibodies, Monoclonal - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Quinazolines - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Feedback, Physiological - drug effects | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Library collections | Studies | Phosphorylation | Kinases | Tumors | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2012, Volume 109, Issue 6, pp. E353 - E359
Carcinomas are comprised of transformed epithelial cells that are supported in their growth by a dedicated neovasculature. How the genetic milieu of the... 
Personalized medicine | Targeted therapy | Tumor suppressor gene | targeted therapy | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CANCER | TUMOR ANGIOGENESIS | METASTATIC COLORECTAL-CANCER | personalized medicine | LUNG-CANCER | ANTIANGIOGENIC THERAPY | PHASE-II TRIAL | SIGNALING PATHWAY | GENE-EXPRESSION | B-RAF | tumor suppressor gene | INDUCIBLE FACTOR-1-ALPHA EXPRESSION | Blood Vessels - pathology | Humans | Molecular Targeted Therapy | Bevacizumab | Necrosis | Neovascularization, Pathologic - pathology | Neovascularization, Pathologic - enzymology | Angiogenesis Inducing Agents - metabolism | Antibodies, Monoclonal, Humanized - pharmacology | Chorioallantoic Membrane - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Indoles - pharmacology | Cytostatic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins B-raf - metabolism | Chorioallantoic Membrane - blood supply | Cell Hypoxia - drug effects | Protein-Serine-Threonine Kinases - genetics | Neoplasms - enzymology | Neoplasms - blood supply | Down-Regulation - drug effects | Mutation - genetics | Sulfonamides - pharmacology | Gene Knock-In Techniques | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Chickens | Alleles | Blood Vessels - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Angiogenesis | Hypoxia | Kinases | Cells | Cancer | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, pp. 9054 - 9054
Aberrant cholesterol homeostasis and biosynthesis has been observed in different tumour types. This paper investigates the role of the post-squalenic enzyme of... 
COLON-CANCER | ANTIANGIOGENIC THERAPY | MULTIDISCIPLINARY SCIENCES | ENDOTHELIAL-CELLS | PANCREATIC-CANCER | 2,3-OXIDOSQUALENELANOSTEROL CYCLASE | RO 48-8071 | ANTIFUNGAL DRUG ITRACONAZOLE | GROWTH-FACTOR | INHIBITORS | HYPOXIA | Neoplasms - metabolism | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | Humans | Benzophenones - pharmacology | Male | Phosphatidylinositol 3-Kinases - metabolism | Colonic Neoplasms - metabolism | Neoplasm Metastasis | Fluorouracil - administration & dosage | Proto-Oncogene Proteins c-akt - metabolism | Disease Models, Animal | HCT116 Cells | Cell Adhesion - drug effects | Benzophenones - administration & dosage | Neoplasms - drug therapy | Intramolecular Transferases - metabolism | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Neovascularization, Pathologic - drug therapy | Colonic Neoplasms - pathology | Intramolecular Transferases - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Fluorouracil - pharmacology | Mice | Neovascularization, Pathologic - metabolism | Cholesterol - biosynthesis | Neoplasms - pathology | Adenocarcinoma | Enzymes | Phosphorylation | Animal models | Leukocyte migration | 5-Fluorouracil | Homeostasis | AKT protein | Biosynthesis | Metastasis | Cholesterol | Cell adhesion & migration | 1-Phosphatidylinositol 3-kinase | Metastases | Angiogenesis | Pancreatic carcinoma | Rodents | Cell adhesion | Colon | Pancreas | Cell migration | Cancer | Tumors | Index Medicus
Journal Article