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PAIN, ISSN 0304-3959, 05/2019, Volume 160, pp. S17 - S22
Peripheral neuropathy is the most common neurodegenerative disease affecting hundreds of millions of patients worldwide and is an important cause of chronic... 
ACTIVATION | PROTEIN | Sarmoptosis | DLK kinase | SELF-DESTRUCTION | WALLERIAN DEGENERATION | INJURY | NMNAT2 | NEUROSCIENCES | CLINICAL NEUROLOGY | CELL-DEATH | NAD | SYNAPTIC GROWTH | SARM1 | ANESTHESIOLOGY | NEUROMUSCULAR-JUNCTION | PHR1 ligase | LEUCINE-ZIPPER KINASE
Journal Article
Cell Reports, ISSN 2211-1247, 09/2019, Volume 28, Issue 10, pp. 2581 - 2593.e5
Fragile X syndrome (FXS) is the leading heritable cause of intellectual disability and commonly co-occurs with autism spectrum disorder. Silencing of the Fmr1... 
neurodevelopment | neuromuscular junction | JNK | neurodegeneration | synaptic transmission | highwire | GNE-3511 | grooming behavior | SYNAPTIC GROWTH | MESSENGER-RNAS | METABOTROPIC GLUTAMATE-RECEPTOR | GENETIC-ANALYSIS | AXON SELF-DESTRUCTION | MOUSE MODEL | KNOCKOUT MICE | MENTAL-RETARDATION PROTEIN | EXPRESSION | LEUCINE-ZIPPER KINASE | CELL BIOLOGY
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2010, Volume 191, Issue 1, pp. 211 - 223
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2018, Volume 115, Issue 37, p. E8746
Axon degeneration is a prominent event in many neurodegenerative disorders. Axon injury stimulates an intrinsic self-destruction program that culminates in... 
Neuroprotection | Cell survival | Deactivation | Neurodegenerative diseases | Neurons | Palmitoylation | Homeostasis | MAP kinase | Pharmacology | Leucine | Kinases | Inactivation | Fatty acids | Survival | Leucine zipper proteins | Proteins | Axons | Neurodegeneration | Degeneration | Survival factor | Localization | Dismantling
Journal Article
Annual Review of Neuroscience, ISSN 0147-006X, 2004, Volume 27, Issue 1, pp. 223 - 246
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 1, pp. 57 - 69
Highwire is an extremely large, evolutionarily conserved E3 ubiquitin ligase that negatively regulates synaptic growth at the NMJ. Highwire has been proposed... 
DEVBIO | MOLNEURO | SIGNALING | DROSOPHILA NEUROMUSCULAR-JUNCTION | ACTIVATED PROTEIN-KINASE | GENE | II RECEPTOR | ENDODERM INDUCTION | MOLECULAR-CLONING | C-ELEGANS | ZIPPER-BEARING KINASE | EXPRESSION | NEUROSCIENCES | MOUSE EMBRYO | Drosophila melanogaster - embryology | MAP Kinase Signaling System - physiology | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Drosophila Proteins - metabolism | Central Nervous System - embryology | Central Nervous System - growth & development | Cell Differentiation - genetics | Female | Growth Inhibitors - genetics | Hydrolases - metabolism | MAP Kinase Kinase Kinases - genetics | Drosophila melanogaster - cytology | Proto-Oncogene Proteins c-fos - metabolism | Ubiquitin-Protein Ligases - metabolism | Synapses - enzymology | Synapses - ultrastructure | Chromosome Mapping | MAP Kinase Kinase Kinases - metabolism | Nerve Tissue Proteins - genetics | Drosophila Proteins - isolation & purification | Growth Cones - enzymology | MAP Kinase Kinase Kinases - isolation & purification | Growth Inhibitors - metabolism | Nerve Tissue Proteins - metabolism | Animals | Central Nervous System - cytology | Growth Cones - ultrastructure | Drosophila melanogaster - growth & development | Drosophila Proteins - genetics | Ubiquitin | Enzymes | Hydrolases | Gene expression | Growth | Ligases | Proteins | Mutation | Insects | Kinases | Neurons | Colleges & universities
Journal Article
Journal Article