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CLINICAL PHARMACOLOGY & THERAPEUTICS, ISSN 0009-9236, 02/2011, Volume 89, Issue 2, pp. 320 - 320
Journal Article
Clinical Pharmacokinetics, ISSN 0312-5963, 1989, Volume 16, Issue 4, pp. 215 - 237
5-Fluorouracil, first introduced as a rationally synthesized anticancer agent 30 years ago, continues to be widely used in the management of several common... 
PHARMACOLOGY & PHARMACY | Fluorouracil - therapeutic use | Female | Male | Fluorouracil - pharmacology | Fluorouracil - pharmacokinetics | Humans
Journal Article
by Siddiq, A and Couch, F.J and Chen, G.K and Lindstrom, S and Eccles, D and Millikan, R.C and Michailidou, K and Stram, D.O and Beckmann, L and Rhie, S.K and Ambrosone, C.B and Aittomaki, K and Amiano, P and Apicella, C and Baglietto, L and Bandera, E.V and Beckmann, M.W and Berg, C.D and Bernstein, L and Blomqvist, C and Brauch, H and Brinton, L and Bui, Q.M and Buring, J.E and Buys, S.S and Campa, D and Carpenter, J.E and Chasman, D.I and Chang-Claude, J and Chen, C and Clavel-Chapelon, F and Cox, A and Cross, S.S and Czene, K and Deming, S.L and Diasio, R.B and Diver, W.R and Dunning, A.M and Durcan, L and Ekici, A.B and Fasching, P.A and Feigelson, H.S and Fejerman, L and Figueroa, J.D and Fletcher, O and Flesch-Janys, D and Gaudet, M.M and Gerty, S.M and Roiguez-Gil, J.L and Giles, G.G and van Gils, C.H and Godwin, A.K and Graham, N and Greco, D and Hall, P and Hankinson, S.E and Hartmann, A and Hein, R and Heinz, J and Hoover, R.N and Hopper, J.L and Hu, J.J and Huntsman, S and Ingles, S.A and Irwanto, A and Isaacs, C and Jacobs, K.B and John, E.M and Justenhoven, C and Kaaks, R and Kolonel, L.N and Coetzee, G.A and Lathrop, M and Le Marchand, L and Lee, AM and Lee, I.M and Lesnick, T and Lichtner, P and Liu, J.J and Lund, E and Makalic, E and Martin, N.G and McLean, C.A and Meijers-Heijboer, E.J and Meindl, A and Miron, P and Monroe, K.R and Montgomery, G.W and Muller-Myhsok, B and Nickels, S and Nyante, S.J and Olswold, C and Overvad, K and Palli, D and Park, D.J and Palmer, J.R and Pathak, H and Peto, J and Pharoah, P
Human Molecular Genetics, ISSN 0964-6906, 2012, Volume 21, Issue 24, pp. 5373 - 5384
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 12/2006, Volume 80, Issue 3, pp. 261 - 274
The limited success of empirically designed treatment paradigms for patients diagnosed with glioblastoma multiforme (GBM) emphasizes the need for rationally... 
Real-time quantitative PCR | Ubiquitin specific protease 10 | Thymidylate synthetase | Ribonucleotide reductase subunit M2 | Medicine & Public Health | Glioma | Oncology | Low density array | Survivin | Glioblastoma multiforme | Survival | glioblastoma multiforme | survivin | LONG-TERM SURVIVAL | DNA MICROARRAY | survival | ribonucleotide reductase subunit M2 | COLORECTAL-CARCINOMA | CANCER | low density array | real-time quantitative PCR | CLINICAL NEUROLOGY | MALIGNANT GLIOMA | RIBONUCLEOTIDE REDUCTASE | PROGNOSTIC-FACTOR | ONCOLOGY | GENE-EXPRESSION | glioma | thymidylate synthetase | POLYMERASE CHAIN-REACTION | M2 SUBUNIT | ubiquitin specific protease 10 | Age Factors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Gene Expression Profiling | Neoplasm Proteins - metabolism | Brain Neoplasms - metabolism | Statistics, Nonparametric | Biomarkers, Tumor - metabolism | Adult | Female | Glioblastoma - metabolism | Retrospective Studies | Brain Neoplasms - mortality | Neoplasm Proteins - genetics | Child | Endopeptidases - metabolism | Inhibitor of Apoptosis Proteins | RNA - analysis | Thymidylate Synthase - metabolism | Thymidylate Synthase - genetics | Disease-Free Survival | Endopeptidases - genetics | Adolescent | Aged | Glioblastoma - mortality | Ubiquitin Thiolesterase | Brain tumors
Journal Article
Pakistan Journal of Medical Sciences, ISSN 1682-024X, 10/2007, Volume 23, Issue 6, pp. 832 - 839
Objectives: 5-Fluorouracil (5-FU) is an integral part of treatment of GI malignancies. White normal DPD enzyme activity is rate limiting in 5-FU catabolism,... 
Fluoropyrimidines | Mucositis | 5-Fluorouracil | HFS | Capecitabine | Uridine | DPD | DPYD gene | Neutropenia | 5-FLUOROURACIL TOXICITY | POPULATION | THYMIDYLATE SYNTHASE | neutropenia | URIDINE RESCUE | CHEMOTHERAPY | 5-fluorouracil | uridine | BREAST-CANCER | capecitabine | mucositis | MEDICINE, GENERAL & INTERNAL | CANCER-PATIENTS | COLORECTAL-CANCER | fluoropyrimidines | PHASE-I | GENE-EXPRESSION LEVELS
Journal Article
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, ISSN 1570-0232, 08/1997, Volume 696, Issue 2, pp. 183 - 191
Dihydropyrimidine dehydrogenase (DPD) catalyzes the reduction of the naturally occurring pyrimidines, uracil and thymine, and the fluoropyrimidine anticancer... 
5-fluorouracil | CHEMISTRY, ANALYTICAL | dihydropyrimidine dehydrogenase | CATABOLISM | LIVER | PURIFICATION | BIOCHEMICAL RESEARCH METHODS | enzymes | PYRIMIDINE ANALOGS | CHEMOTHERAPY
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 10/2006, Volume 17, Issue 9, pp. 1095 - 1098
Peripheral neuropathy secondary to 5-flourouracil and capecitabine (Xeloda) has been reported. We report the first case of exacerbation of peripheral... 
Journal Article
Biochemistry and Cell Biology, ISSN 0829-8211, 06/2007, Volume 85, Issue 3, pp. 337 - 346
Dihydropyrimidine dehydrogenase (DPD) is one of the factors that determine the efficacy and toxicity of 5-fluorouracil. Variations in DPD activity may result... 
DPDY | promoteur | méthylation d'ADN | dihydropyrimidine dehydrogenase | dihydropyrimidine déshydrogénase | DPYD | colorectal cancer RKO cell line | DNA methylation | promoter | cellule de cancer colorectal RKO | Promoter | Dihydropyrimidine dehydrogenase | Colorectal cancer RKO cell line | THYMIDYLATE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | DIHYDROPYRIMIDINE DEHYDROGENASE-ACTIVITY | CPG METHYLATION | dihydropyrinfidine dehydrogenase | CELL BIOLOGY | 5-FLUOROURACIL | GASTRIC-CANCER | SP1 | COLORECTAL-CANCER | GENE-EXPRESSION | THYMIDINE PHOSPHORYLASE | Promoter Regions, Genetic | DNA, Neoplasm - metabolism | Colorectal Neoplasms - genetics | Epigenesis, Genetic | Humans | RNA, Messenger - genetics | Azacitidine - analogs & derivatives | Sp1 Transcription Factor - metabolism | DNA Primers - genetics | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Gene Expression Regulation, Enzymologic | Azacitidine - pharmacology | DNA Methylation | Base Sequence | Colorectal Neoplasms - drug therapy | Cell Line, Tumor | RNA, Neoplasm - genetics | DNA, Neoplasm - genetics | Hydroxamic Acids - pharmacology | Colorectal Neoplasms - metabolism | Dihydrouracil Dehydrogenase (NADP) - genetics | Suppression, Genetic | Colorectal cancer | Physiological aspects | Genetic aspects | Chemical properties | Dihydropyridine | Oxidoreductases | Drug therapy | Fluorouracil | Proteins | Studies | Chemotherapy | Genetics | Gene expression | DNA repair | Cells | Deoxyribonucleic acid--DNA | Binding sites | Ovarian cancer
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 03/1996, Volume 2, Issue 3, pp. 477 - 481
Patients with decreased dihydropyrimidine dehydrogenase (DPD) activity are at increased risk for experiencing serious adverse reactions following... 
THYMIDINE | TOXICITY | FAMILIAL PYRIMIDINEMIA | ONCOLOGY | BIOCHEMICAL BASIS | LIVER | Fluorouracil - metabolism | Fluorouracil - adverse effects | Humans | Middle Aged | Male | Oxidoreductases - deficiency | Dihydrouracil Dehydrogenase (NADP) | Brain Diseases - chemically induced
Journal Article
Journal Article
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