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1. Full Text Epigenetic mechanisms of protein tyrosine phosphatase 6 suppression in diffuse large B-cell lymphoma: Implications for epigenetic therapy
by Witzig, T.E and Hu, G and Offer, S.M and Wellik, L.E and Han, J.J and Stenson, M.J and Dogan, A and Diasio, R.B and Gupta, M
Leukemia, ISSN 0887-6924, 2014, Volume 28, Issue 1, pp. 147 - 154
CpG methylation | histone methylation | DLBCL | PTPN6 | azacytidine | LBH589 | Oncology | Life Sciences & Biomedicine | Hematology | Science & Technology | Promoter Regions, Genetic | Lymphoma, Large B-Cell, Diffuse - pathology | Epigenesis, Genetic | Humans | Phosphoprotein Phosphatases - antagonists & inhibitors | DNA Primers | DNA Methylation | Lymphoma, Large B-Cell, Diffuse - therapy | Chromatin Immunoprecipitation | Base Sequence | Polymerase Chain Reaction | CpG Islands | Lymphoma, Large B-Cell, Diffuse - genetics | Epigenetic inheritance | Phosphatases | Genetic research | Lymphomas | Genetic aspects | Research | Identification and classification | Index Medicus | Azacytidine
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2. Full Text Common oncogene mutations and novel SND1-BRAF transcript fusion in lung adenocarcinoma from never smokers
by Jang, Jin Sung and Lee, Adam and Li, Jun and Liyanage, Hema and Yang, Yanan and Guo, Lixia and Asmann, Yan W and Li, Peter W and Erickson-Johnson, Michele and Sakai, Yuta and Sun, ZhiFu and Jeon, Hyo-Sung and Hwang, Hayoung and Bungum, Aaron O and Edell, Eric S and Simon, Vernadette A and Kopp, Karla J and Eckloff, Bruce and Oliveira, Andre M and Wieben, Eric and Aubry, Marie Christine and Yi, Eunhee and Wigle, Dennis and Diasio, Robert B and Yang, Ping and Jen, Jin
Scientific reports, ISSN 2045-2322, 05/2015, Volume 5, Issue 1, pp. 9755 - 9755
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oncogene Proteins, Fusion - metabolism | Phosphorylation | Adenocarcinoma - pathology | Adenocarcinoma of Lung | Humans | Lung Neoplasms - metabolism | Middle Aged | Lung Neoplasms - pathology | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Biomarkers, Tumor | Adenocarcinoma - metabolism | Aged, 80 and over | Female | Transcription, Genetic | Adenocarcinoma - genetics | Nuclear Proteins - genetics | Gene Order | Oncogenes | Proto-Oncogene Proteins B-raf - metabolism | Lung Neoplasms - genetics | Reproducibility of Results | Nuclear Proteins - metabolism | Oncogene Proteins, Fusion - genetics | Proto-Oncogene Proteins B-raf - genetics | Aged | Mutation | Neoplasm Staging | Mitogen-Activated Protein Kinases - metabolism | Cell proliferation | Adenocarcinoma | Epidermal growth factor receptors | Transcription | Exons | Lung cancer | Extracellular signal-regulated kinase | Ribonucleic acid--RNA | ErbB-2 protein | K-Ras protein | Ret protein | Novels | Tumors | Index Medicus
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3. Histone deacetylase inhibitors: Current status and overview of recent clinical trials
by Ma, Xujun and Ezzeldin, Hany H and Diasio, Robert B
Drugs (New York, N.Y.), ISSN 0012-6667, 2009, Volume 69, Issue 14, pp. 1911 - 1934
Pharmacology & Pharmacy | Toxicology | Life Sciences & Biomedicine | Science & Technology | Gene Expression - drug effects | Humans | Neoplasms - enzymology | Histone Deacetylases - metabolism | Antineoplastic Agents - therapeutic use | Clinical Trials as Topic | Enzyme Inhibitors - therapeutic use | Forecasting | Neoplasms - drug therapy | Acetylation - drug effects | Neoplasms - genetics | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Models, Biological | Histone Acetyltransferases - antagonists & inhibitors | Histone Acetyltransferases - metabolism | Epigenesis, Genetic - drug effects | Histone Deacetylase Inhibitors
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4. Full Text A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population
by Antoniou, Antonis C and Tarrell, Robert and Healey, Sue and Ghoussaini, Maya and Peock, Susan and Frost, Debra and Eccles, Diana and Evans, D. Gareth and Eeles, Ros and Chu, Carol and Douglas, Fiona and Paterson, Joan and Houdayer, Claude and Lasset, Christine and Remenieras, Auey and Caron, Olivier and Hardouin, Agnès and Hogervorst, Frans B. L and Rookus, Matti A and Jager, Agnes and Hoogerbrugge, Nicoline and van der Luijt, Rob B and Meijers-Heijboer, Hanne and Devilee, Peter and Vreeswijk, Maaike P. G and Gronwald, Jacek and Huzarski, Tomasz and Spurdle, Amanda B and Holland, Helene and Goldgar, David E and John, Esther M and Hopper, John L and Southey, Melissa and Daly, Mary B and Terry, Mary-Beth and Schmutzler, Rita K and Wappenschmidt, Barbara and Engel, Christoph and Meindl, Alfons and Preisler-Adams, Sabine and Arnold, Norbert and Sutter, Christian and Domchek, Susan M and Rebbeck, Timothy and Wakeley, Katie and Kaufman, Bella and Glendon, Gord and Vijai, Joseph and Gaudet, Mia M and Altshuler, David and Guiducci, Candace and Loman, Niklas and Harbst, Katja and Rantala, Johanna and Gerdes, Anne-Marie and Sunde, Lone and Manoukian, Siranoush and Viel, Alessana and Radice, Paolo and Caldes, Trinidad and Loud, Jennifer T and Blanco, Ignacio and Garber, Judy and Gayther, Simon A and Szabo, Csilla I and Benitez, Javier and Osorio, Ana and Nevanlinna, Heli and Heikkinen, Tuomas and Caligo, Maria A and Beattie, Mary S and Hamann, Ute and Montagna, Marco and Casella, Cinzia and Karlan, Beth Y and Tung, Nadine and Toland, Amanda E and Weitzel, Jeffrey and Simard, Jacques and Rubinstein, Wendy S and Rennert, Gad and Martin, Nicholas G and Montgomery, Grant W and Chang-Claude, Jenny and Flesch-Janys, Dieter and Severi, Gianluca and Baglietto, Laura and Cox, Angela and Cross, Simon S and Miron, Penelope and Yannoukakos, koulis and Beckmann, Matthias W and Peto, Julian and Paridaens, Robert and Försti, Asta and Diasio, Robert B and Eckel-Passow, Jeanette and Pharoah, Paul P. D and Offit, Kenneth and Hakonarson, Hakon and KConFab and EMBRACE and GEMO Study Collaborators and GENICA and MOD SQUAD and HEBON and SWE-BRCA and kConFab
Nature genetics, ISSN 1061-4036, 2010, Volume 42, Issue 10, pp. 885 - 892
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Tumors | Genetic Predisposition to Disease | Receptors, Estrogen - genetics | Receptor, ErbB-2 - genetics | Humans | Genotype | Receptors, Progesterone - genetics | Mutation - genetics | Case-Control Studies | BRCA1 Protein - genetics | Chromosomes, Human, Pair 19 - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Polymorphism, Single Nucleotide - genetics | Adult | Female | Demographic aspects | BRCA mutations | Breast cancer | Genetic aspects | Research | Single nucleotide polymorphisms | Health aspects | Risk factors | Ovarian cancer | Studies | Medical research | Mutation | Index Medicus | Life Sciences | Other | Medical and Health Sciences | Medicin och hälsovetenskap | Estrogen | Breast Neoplasms | Klinisk medicin | Single Nucleotide | Receptors | Chromosomes | Human | Clinical Medicine | Receptor | Pair 19 | Progesterone | Cancer and Oncology | BRCA1 Protein | Polymorphism | erbB-2 | Cancer och onkologi
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5. Full Text Adverse Prognostic Impact of Intratumor Heterogeneous HER2 Gene Amplification in Patients With Esophageal Adenocarcinoma
by Harry H. Yoon and Qian Shi and William R. Sukov and Mark A. Lewis and Christopher A. Sattler and Anne E. Wiktor and Tsung-Teh Wu and Robert B. Diasio and Robert B. Jenkins and Frank A. Sinicrope
Journal of clinical oncology, ISSN 0732-183X, 11/2012, Volume 30, Issue 32, pp. 3932 - 3938
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Biological and medical sciences | Medical sciences | Tumors | Esophagus | Predictive Value of Tests | Adenocarcinoma - pathology | Prognosis | Humans | Middle Aged | Aneuploidy | Male | Esophageal Neoplasms - pathology | Neoplasm Grading | Esophageal Neoplasms - surgery | Adult | Female | Adenocarcinoma - genetics | Kaplan-Meier Estimate | Proportional Hazards Models | In Situ Hybridization, Fluorescence | Lymphatic Metastasis | Phosphoproteins - genetics | Gene Amplification | Esophageal Neoplasms - genetics | Genes, erbB-2 | Chromosome Aberrations | Aged | Neoplasm Staging | Adenocarcinoma - surgery | Index Medicus | Fra | Original Reports | Gic14
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6. Full Text Expression but Not Promoter Hypermethylation of the Tyrosine Phosphatase PTPN6 Is Associated with Activated STAT3 and Inferior Prognosis in Diffuse Large B Cell Lymphoma Molecular Subtypes
by Gupta, Mamta and Hu, Guangzhen and Offer, Steven and Maurer, Matthew J and Wellik, Linda and Han, Jing Jing and Dogan, Ahmet and Diasio, Robert B and Witzig, Thomas E
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 2655 - 2655
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7. Full Text Association of HER2/ErbB2 expression and gene amplification with pathologic features and prognosis in esophageal adenocarcinomas
by Yoon, Harry H and Shi, Qian and Sukov, William R and Wiktor, Anne E and Khan, Maliha and Sattler, Christopher A and Grothey, Axel and Wu, Tsung-Teh and Diasio, Robert B and Jenkins, Robert B and Sinicrope, Frank A
Clinical cancer research, ISSN 1078-0432, 01/2012, Volume 18, Issue 2, pp. 546 - 554
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Esophagus | Tumors | Multivariate Analysis | Adenocarcinoma - pathology | Prognosis | Receptor, ErbB-2 - genetics | Humans | Middle Aged | Receptor, ErbB-2 - metabolism | Male | Precancerous Conditions - metabolism | Esophageal Neoplasms - pathology | Adenocarcinoma - metabolism | Barrett Esophagus - pathology | Precancerous Conditions - mortality | Esophageal Neoplasms - metabolism | Esophageal Neoplasms - mortality | Female | Precancerous Conditions - pathology | Adenocarcinoma - genetics | Barrett Esophagus - genetics | Barrett Esophagus - metabolism | Gene Expression | Neoplasm Invasiveness | Risk Factors | Barrett Esophagus - mortality | Kaplan-Meier Estimate | Logistic Models | Gene Dosage | Precancerous Conditions - genetics | Gene Amplification | Esophageal Neoplasms - genetics | Adenocarcinoma - mortality | Cohort Studies | Index Medicus
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8. Full Text Benefit of uridine triacetate (Vistogard) in rescuing severe 5-fluorouracil toxicity in patients with dihydropyrimidine dehydrogenase (DPYD) deficiency
by Saif, Muhammad Wasif and Diasio, Robert B
Cancer chemotherapy and pharmacology, ISSN 0344-5704, 7/2016, Volume 78, Issue 1, pp. 151 - 156
Fluoropyrimidines | Medicine & Public Health | 5-Fluorouracil | Uridine | Oncology | Cancer Research | Pharmacology/Toxicology | PN401 | DPYD gene | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Science & Technology | Severity of Illness Index | Humans | Uridine - analogs & derivatives | Uridine - therapeutic use | Male | Antimetabolites, Antineoplastic - administration & dosage | Pancreatic Neoplasms - drug therapy | Dihydropyrimidine Dehydrogenase Deficiency - complications | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Time Factors | Antimetabolites, Antineoplastic - adverse effects | Female | Acetates - therapeutic use | Aged | Antidotes - therapeutic use | Enzymes | Chemotherapy | Care and treatment | Analysis | Poisoning | Fluorouracil | Cancer | Index Medicus
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9. Full Text Is it finally time for a personalized medicine approach for fluorouracil-based therapies?
by Offer, Steven M and Diasio, Robert B
Journal of clinical oncology, ISSN 0732-183X, 01/2016, Volume 34, Issue 3, pp. 205 - 207
Life Sciences & Biomedicine | Oncology | Science & Technology | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Pyrimidines - administration & dosage | Humans | Female | Male | Genotyping Techniques - methods | Dihydrouracil Dehydrogenase (NADP) - genetics | Precision Medicine - methods | Index Medicus
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10. Full Text Predicting fluorouracil toxicity: can we finally do it?
by Ezzeldin, Hany H and Diasio, Robert B
Journal of clinical oncology, ISSN 0732-183X, 2008, Volume 26, Issue 13, pp. 2080 - 2082
Life Sciences & Biomedicine | Oncology | Science & Technology | Predictive Value of Tests | Genetic Testing | Humans | Leukopenia - genetics | Diarrhea - chemically induced | Patient Selection | Leucovorin - adverse effects | Fluorouracil - adverse effects | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Leukopenia - chemically induced | Odds Ratio | Severity of Illness Index | Genetic Predisposition to Disease | Vitamin B Complex - adverse effects | Risk Assessment | Risk Factors | Logistic Models | Thymidylate Synthase - genetics | Mucositis - chemically induced | Polymorphism, Genetic | Diarrhea - genetics | Mucositis - etiology | Antimetabolites, Antineoplastic - adverse effects | Diarrhea - etiology | Mucositis - genetics | Leukopenia - etiology | Dihydrouracil Dehydrogenase (NADP) - genetics | Index Medicus
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11. Full Text Colorectal Tumors Responding to 5-Fluorouracil Have Low Gene Expression Levels of Dihydropyrimidine Dehydrogenase, Thymidylate Synthase, and Thymidine Phosphorylase
by Dennis Salonga and Kathleen D. Danenberg and Martin Johnson and Ralf Metzger and Susan Groshen and Denice D. Tsao-Wei and Heinz-Josef Lenz and C. Gail Leichman and Lawrence Leichman and Robert B. Diasio and Peter V. Danenberg
Clinical cancer research, ISSN 1078-0432, 04/2000, Volume 6, Issue 4, pp. 1322 - 1327
Life Sciences & Biomedicine | Oncology | Science & Technology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Chemotherapy | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Gene Expression Regulation, Enzymologic - drug effects | Drug Administration Schedule | Oxidoreductases - genetics | Colorectal Neoplasms - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Thymidylate Synthase - genetics | Fluorouracil - therapeutic use | Antimetabolites, Antineoplastic - therapeutic use | Colorectal Neoplasms - drug therapy | Enzymes - genetics | Thymidine Phosphorylase - genetics | Survival Analysis | Gene Expression Regulation, Neoplastic - drug effects | Infusions, Intravenous | Colorectal Neoplasms - pathology | Dihydrouracil Dehydrogenase (NADP) | Index Medicus
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