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neurosciences (117) 117
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PAIN, ISSN 0304-3959, 10/2012, Volume 153, Issue 10, pp. 2017 - 2030
A vast diversity of salient cues is sensed by numerous classes of primary sensory neurons, defined by specific neuropeptides, ion channels, or cytoskeletal... 
GENE-RELATED PEPTIDE | C fiber | PRIMARY AFFERENT NEURONS | tdTomato | DRG NEURONS | VGSC | SPINAL-CORD | Scn10a | DORSAL-ROOT GANGLION | NEUROSCIENCES | CLINICAL NEUROLOGY | Nociceptive | NEUROPATHIC PAIN | ANESTHESIOLOGY | INFLAMMATORY PAIN | PRIMARY SENSORY NEURONS | RESISTANT SODIUM-CHANNELS | SUBSTANCE-P | C-LTM
Journal Article
NEURON, ISSN 0896-6273, 03/2019, Volume 101, Issue 5, pp. 765 - 767
Sodium channel Na(V)1.7 is a major target in pain research, largely because of genetic validation. In this issue of Neuron, McDermott et al. (2019) now present... 
NEUROSCIENCES
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 01/2013, Volume 14, Issue 1, pp. 49 - 62
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 47, pp. 19444 - 19449
Painful peripheral neuropathy often occurs without apparent underlying cause. Gain-of-function variants of sodium channel Na(v)1.7 have recently been found in... 
NERVE | patch clamp | RAT | MULTIDISCIPLINARY SCIENCES | dorsal root ganglia | DRG NEURONS | SMALL FIBER NEUROPATHY | INJURY | SODIUM-CHANNEL | SENSORY NEURONS | DENSITY | ERYTHROMELALGIA | EXPRESSION
Journal Article
Nature Reviews Neuroscience, ISSN 1471-003X, 08/2015, Volume 16, Issue 9, pp. 511 - 519
The voltage-gated sodium channel Na(V)1.9 is preferentially expressed in nociceptors and has been shown in rodent models to have a major role in inflammatory... 
NA(V)1.8 MUTATION | RESISTANT | ROOT GANGLION NEURONS | NOCICEPTORS | MOUSE | VOLTAGE SENSOR | OF-FUNCTION MUTATIONS | NAV1.9 | EXPRESSION | NEUROSCIENCES | SENSORY NEURONS
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 03/2018, Volume 39, Issue 3, pp. 258 - 275
Chronic pain is a global unmet medical need. Most existing treatments are only partially effective or have side effects that limit their use. Rapid progress in... 
PLURIPOTENT STEM-CELLS | OF-FUNCTION MUTATION | INHERITED ERYTHROMELALGIA | CRYSTAL-STRUCTURE | GATED SODIUM-CHANNELS | PHARMACOLOGY & PHARMACY | CHANNEL ALPHA-SUBUNIT | ROOT GANGLIA NEURONS | CYSTIC-FIBROSIS | CFTR POTENTIATOR | SENSORY NEURONS
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2012, Volume 32, Issue 32, pp. 10819 - 10832
Marked hypersensitivity to heat and mechanical (pressure) stimuli develop after a burn injury, but the neural mechanisms underlying these effects are poorly... 
OF-FUNCTION MUTATION | NEUROPATHIC PAIN | TETRODOTOXIN-RESISTANT | TACTILE ALLODYNIA | SPINAL-CORD | PRIMARY SENSORY NEURONS | FOS-LIKE IMMUNOREACTIVITY | DORSAL-ROOT GANGLION | NERVE INJURY | NEUROSCIENCES | RESISTANT NA+ CURRENT | Pain Threshold - physiology | Membrane Potentials - genetics | Electric Stimulation | Calcium - metabolism | Neuroglia - pathology | Glycoproteins - metabolism | NAV1.7 Voltage-Gated Sodium Channel | Ganglia, Spinal - cytology | Neuralgia - pathology | RNA, Messenger - metabolism | Hyperalgesia - pathology | Transfection | Neuralgia - etiology | Sodium Channels - metabolism | Sensory Receptor Cells - metabolism | Tetrodotoxin - pharmacology | Calcitonin Gene-Related Peptide - metabolism | Burns - complications | Sodium Channels - deficiency | Disease Models, Animal | Membrane Potentials - drug effects | Cytokines - metabolism | Hot Temperature - adverse effects | Mice, Inbred C57BL | RNA, Untranslated | Cells, Cultured | Mice, Transgenic | Sodium Channel Blockers - pharmacology | Biophysics | Functional Laterality | NAV1.9 Voltage-Gated Sodium Channel | Activating Transcription Factor 3 - metabolism | Proteins - genetics | Edema - etiology | Patch-Clamp Techniques | Animals | NAV1.8 Voltage-Gated Sodium Channel | Sensory Receptor Cells - drug effects | Analysis of Variance | Hyperalgesia - etiology | Mice
Journal Article
Science Translational Medicine, ISSN 1946-6234, 08/2014, Volume 6, Issue 249, pp. 249sr4 - 249sr4
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 09/2004, Volume 24, Issue 38, pp. 8232 - 8236
Journal Article
JOURNAL OF PHYSIOLOGY-LONDON, ISSN 0022-3751, 07/2019, Volume 597, Issue 14, pp. 3751 - 3768
Key points Voltage-gated sodium channels are critical for peripheral sensory neuron transduction and have been implicated in a number of painful and painless... 
ENHANCED ACTIVATION | patch clamp | pain | PHYSIOLOGY | RAT | CONDUCTION-VELOCITY | dorsal root ganglia | nociception | NEUROSCIENCES | ion channels | IN-VITRO | SODIUM-CHANNEL NA(V)1.6 | RESURGENT | SCORPION BETA-TOXIN | COLONIC NOCICEPTORS | MOUSE MODEL | colon | VOLTAGE SENSOR | Skin
Journal Article
NEUROBIOLOGY OF DISEASE, ISSN 0969-9961, 09/2014, Volume 69, pp. 117 - 123
Rare de novo mutations of sodium channels are thought to be an important cause of sporadic epilepsy. The well established role of de novo mutations of sodium... 
PURKINJE NEURONS | Epileptic encephalopathy | NODES | MODIFIER | RANVIER | Epilepsy | SODIUM-CHANNELS | ACTION-POTENTIAL INITIATION | CURRENTS | NEUROSCIENCES | Sodium channel | GENE | De novo mutation | PATIENT | ION CHANNELS
Journal Article