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humans (16) 16
pancreatic cancer (16) 16
science & technology (15) 15
life sciences & biomedicine (13) 13
cell line, tumor (12) 12
chemistry, medicinal (11) 11
drug screening assays, antitumor (11) 11
pharmacology & pharmacy (11) 11
antineoplastic agents, phytogenic - chemistry (10) 10
antineoplastic agents, phytogenic - pharmacology (9) 9
molecular structure (9) 9
preferential cytotoxicity (9) 9
analysis (8) 8
drug discovery (8) 8
antineoplastic agents, phytogenic - isolation & purification (7) 7
panc-1 (7) 7
cell death (6) 6
chemistry (6) 6
pancreatic neoplasms - drug therapy (6) 6
physical sciences (6) 6
dose-response relationship, drug (5) 5
antiausterity agent (4) 4
antiausterity agents (4) 4
cell survival - drug effects (4) 4
congolese medicinal plant (4) 4
cytotoxicity (4) 4
food science & technology (4) 4
nutrients (4) 4
plant extracts - chemistry (4) 4
plants, medicinal - chemistry (4) 4
securidaca longepedunculata (4) 4
animals (3) 3
anneslea fragrans (3) 3
cancer (3) 3
cell proliferation - drug effects (3) 3
chemistry, applied (3) 3
congo (3) 3
medicine, botanic (3) 3
medicine, herbal (3) 3
molecular conformation (3) 3
pancreatic neoplasms - pathology (3) 3
rhizome - chemistry (3) 3
starvation (3) 3
structure-activity relationship (3) 3
toxicity (3) 3
zingiberaceae - chemistry (3) 3
absolute configuration (2) 2
anti-austerity (2) 2
anticancer properties (2) 2
antineoplastic agents, phytogenic - chemical synthesis (2) 2
apoptosis (2) 2
autism (2) 2
autism spectrum disorder (2) 2
autism spectrum disorder - drug therapy (2) 2
autism spectrum disorder - metabolism (2) 2
autophagy - drug effects (2) 2
biochemistry (2) 2
biological and medical sciences (2) 2
biological products - chemical synthesis (2) 2
biological products - chemistry (2) 2
biological products - pharmacology (2) 2
biotechnology (2) 2
caesalpinia - chemistry (2) 2
cancer cells (2) 2
care and treatment (2) 2
cell adhesion & migration (2) 2
cell death - drug effects (2) 2
coumarins (2) 2
cyclohexanes - chemistry (2) 2
cyclohexanes - isolation & purification (2) 2
cyclohexenes - chemistry (2) 2
cyclohexenes - isolation & purification (2) 2
cyclohexenes - pharmacology (2) 2
diagnosis (2) 2
diphenylmethyl-substituted xanthone (2) 2
disease models, animal (2) 2
drugstores (2) 2
female (2) 2
furans - chemistry (2) 2
general pharmacology (2) 2
herbal medicine (2) 2
lignans - chemistry (2) 2
magnetic resonance spectroscopy (2) 2
male (2) 2
medical sciences (2) 2
medicine (2) 2
mice (2) 2
morphology (2) 2
natural products (2) 2
nuclear magnetic resonance, biomolecular (2) 2
nutrition (2) 2
organic chemistry (2) 2
oxygenated (2) 2
pancreatic neoplasms - metabolism (2) 2
pharmacognosy. homeopathy. health food (2) 2
pharmacology. drug treatments (2) 2
pharmacy (2) 2
plant extracts - pharmacology (2) 2
plant roots - chemistry (2) 2
plant sciences (2) 2
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1. Full Text Damnacanthal from the Congolese Medicinal Plant Garcinia huillensis has a Potent Preferential Cytotoxicity against Human Pancreatic Cancer PANC‐1 Cells
by Dibwe, Dya Fita and Awale, Suresh and Kadota, Shigetoshi and Tezuka, Yasuhiro
Phytotherapy research, ISSN 0951-418X, 12/2012, Volume 26, Issue 12, pp. 1920 - 1926
preferential cytotoxicity | damnacanthal | anthraquinone | pancreatic cancer | Garcinia huillensis | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Plants, Medicinal - chemistry | Pancreatic Neoplasms - metabolism | Garcinia - chemistry | Plant Extracts - pharmacology | Humans | Pancreatic Neoplasms - pathology | Anthraquinones - isolation & purification | Cell Line, Tumor | Anthraquinones - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Drug Screening Assays, Antitumor | Pancreatic cancer | Medicine, Botanic | Medicine, Herbal | Index Medicus
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2. Full Text Ancistrolikokine E3, a 5,8′-Coupled Naphthylisoquinoline Alkaloid, Eliminates the Tolerance of Cancer Cells to Nutrition Starvation by Inhibition of the Akt/mTOR/Autophagy Signaling Pathway
by Awale, Suresh and Dibwe, Dya Fita and Balachandran, Chandrasekar and Fayez, Shaimaa and Feineis, Doris and Lombe, Blaise Kimbadi and Bringmann, Gerhard
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 10/2018, Volume 81, Issue 10, pp. 2282 - 2291
Index Medicus
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3. Full Text Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC‑1 Human Pancreatic Cancer Cell Line
by Sun, Sijia and Phrutivorapongkul, Ampai and Dibwe, Dya Fita and Balachandran, Chandrasekar and Awale, Suresh
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 08/2018, Volume 81, Issue 8, pp. 1877 - 1883
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4. Full Text A Triterpene Lactone from Callistemon citrinus Inhibits the PANC‐1 Human Pancreatic Cancer Cells Viability through Suppression of Unfolded Protein Response
by Tawila, Ahmed M and Sun, Sijia and Kim, Min Jo and Omar, Ashraf M and Dibwe, Dya Fita and Awale, Suresh
Chemistry & biodiversity, ISSN 1612-1872, 10/2020, Volume 17, Issue 10, pp. e2000495 - n/a
nutrient-deprived conditions | PANC-1 | proteins | triterpenes | anti-austerity | glucose-regulated proteins | cytotoxicity | TOR protein | Phosphorylation | Starvation | Cell survival | Toxicity | Tumor cells | Cytology | Cytotoxicity | AKT protein | Cell viability | Cell membranes | Rounding | Survival | Cell morphology | Cell adhesion & migration | Anticancer properties | Proteins | Protein folding | Cell death | Morphology | Pancreatic cancer | Nutrients | Cell migration | Tumors | Index Medicus
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5. Full Text Antiausterity Activity of Secondary Metabolites from the Roots of Ferula hezarlalehzarica against the PANC‑1 Human Pancreatic Cancer Cell Line
by Alilou, Mostafa and Dibwe, Dya Fita and Schwaiger, Stefan and Khodami, Mojtaba and Troppmair, Jakob and Awale, Suresh and Stuppner, Hermann
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 04/2020, Volume 83, Issue 4, pp. 1099 - 1106
Index Medicus
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6. Full Text Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC‑1 Human Pancreatic Cancer Line
by Nguyen, Nhan Trung and Nguyen, Mai Thanh Thi and Nguyen, Hai Xuan and Dang, Phu Hoang and Dibwe, Dya Fita and Esumi, Hiroyasu and Awale, Suresh
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 01/2017, Volume 80, Issue 1, pp. 141 - 148
Chalcones - chemistry | Plant Extracts - chemistry | Chalcone - chemistry | Zingiberaceae - chemistry | Cyclohexanes - isolation & purification | Cyclohexanes - pharmacology | Humans | Antineoplastic Agents, Phytogenic - chemistry | Chalcones - isolation & purification | Pancreatic Neoplasms - drug therapy | Chalcone - pharmacology | Rhizome - chemistry | Chalcone - isolation & purification | Chalcones - pharmacology | Cell Line, Tumor | Cyclohexanes - chemistry | Molecular Structure | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
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7. Full Text Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD
by Ebihara, Ken and Fujiwara, Hironori and Awale, Suresh and Dibwe, Dya Fita and Araki, Ryota and Yabe, Takeshi and Matsumoto, Kinzo
Behavioural brain research, ISSN 0166-4328, 09/2017, Volume 334, pp. 6 - 15
Animal model | Type I 5α-reductase inhibitor | Sociability deficit | Restricted repetitive behavior | Autism spectrum disorder | Allopregnanolone | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Behavioral Sciences | Science & Technology | Grooming - physiology | Stereotyped Behavior - physiology | Pregnanolone - deficiency | Male | Methylphenidate - pharmacology | Sex Characteristics | Autism Spectrum Disorder - psychology | Fear - physiology | Mice, Inbred ICR | Brain - drug effects | Brain - metabolism | Learning - physiology | Androstanes | Animals | Social Behavior | Autism Spectrum Disorder - metabolism | Psychotropic Drugs - pharmacology | 5-alpha Reductase Inhibitors - pharmacology | Female | Autism Spectrum Disorder - drug therapy | Anxiety - metabolism | Disease Models, Animal | Memory - physiology | Physiological aspects | GABA | Autism | Social aspects | Analysis | Index Medicus
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8. Full Text Chemical Constituents of Anneslea fragrans and Their Antiausterity Activity against the PANC‑1 Human Pancreatic Cancer Cell Line
by Omar, Ashraf M and Dibwe, Dya Fita and Tawila, Ahmed M and Sun, Sijia and Phrutivorapongkul, Ampai and Awale, Suresh
Journal of natural products (Washington, D.C.), ISSN 0163-3864, 11/2019, Volume 82, Issue 11, pp. 3133 - 3139
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9. Full Text Heptaoxygenated xanthones as anti-austerity agents from Securidaca longepedunculata
by Dibwe, Dya Fita and Awale, Suresh and Kadota, Shigetoshi and Morita, Hiroyuki and Tezuka, Yasuhiro
Bioorganic & medicinal chemistry, ISSN 0968-0896, 12/2013, Volume 21, Issue 24, pp. 7663 - 7668
Xanthone | Preferential cytotoxicity | Congolese medicinal plant | Securidaca longepedunculata | Pancreatic cancer | Xanthones - chemistry | Xanthones - isolation & purification | Humans | Antineoplastic Agents, Phytogenic - chemistry | Securidaca - chemistry | Structure-Activity Relationship | Xanthones - pharmacology | Dose-Response Relationship, Drug | Plant Roots - chemistry | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | Tumor Cells, Cultured | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Index Medicus
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10. Full Text Fragranol A: A new class of spiro-triflavanoid hybrid with an unprecedented carbon skeleton from Anneslea fragrans
by Omar, Ashraf M and Sun, Sijia and Kim, Min Jo and Tawila, Ahmed M and Dibwe, Dya Fita and Phrutivorapongkul, Ampai and Toyooka, Naoki and Awale, Suresh
Tetrahedron letters, ISSN 0040-4039, 07/2020, Volume 61, Issue 29, p. 152099
Anisotropic shielding | Anneslea fragrans | Spiro-flavanoid | Absolute configuration
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11. Full Text Syntheses of benzophenone-xanthone hybrid polyketides and their antibacterial activities
by Kodama, Takeshi and Ito, Takuya and Dibwe, Dya Fita and Woo, So-Yeun and Morita, Hiroyuki
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 06/2017, Volume 27, Issue 11, pp. 2397 - 2400
Benzophenone-xanthone hybrid polyketide | Antibacterial activity | Muchimangin | Brønsted acid-catalysis | Benzophenones - chemistry | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Benzhydryl Compounds - chemical synthesis | Xanthones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Microbial Sensitivity Tests | Polyketides - chemical synthesis | Anti-Bacterial Agents - pharmacology | Benzhydryl Compounds - pharmacology | Staphylococcus aureus - drug effects | Bacillus subtilis - drug effects | Polyketides - pharmacology | Xanthones - chemical synthesis | Antibacterial agents | Index Medicus
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12. Full Text Anti-Austerity Agents from Rhizoma et Radix Notopterygii (Qianghuo)
by Li, Feng and Okamura, Yukari and Dibwe, Dya Fita and Awale, Suresh and Kadota, Shigetoshi and Tezuka, Yasuhiro
Planta medica, ISSN 0032-0943, 05/2012, Volume 78, Issue 8, pp. 796 - 799
Biological and Pharmacological Activity | anti-austerity strategy | pancreatic cancer | Notopterygium incisum Ting ex H. T. Chang | Notopterygium forbesii Boiss | Rhizoma et Radix Notopterygii | Umbelliferae | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Integrative & Complementary Medicine | Plant Sciences | Science & Technology | Biological and medical sciences | Pharmacognosy. Homeopathy. Health food | Medical sciences | General pharmacology | Pharmacology. Drug treatments | Plants, Medicinal - chemistry | Rhizome - chemistry | Drugs, Chinese Herbal - chemistry | Humans | Cell Line, Tumor | Apiaceae - chemistry | Umbelliferones - isolation & purification | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Fertilization in vitro | Composition | Care and treatment | Apiaceae | Growth | Pancreatic cancer | Research | Diagnosis
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13. Full Text Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti‐Austerity Activity against Human PANC‐1 Pancreatic Cancer Cells
by Alexander, Benjamin E and Sun, Sijia and Palframan, Matthew J and Kociok‐Köhn, Gabriele and Dibwe, Dya Fita and Watanabe, Shiro and Caggiano, Lorenzo and Awale, Suresh and Lewis, Simon E
ChemMedChem, ISSN 1860-7179, 01/2020, Volume 15, Issue 1, pp. 125 - 135
dimerization | cancer | antiproliferation | nutrient deprivation | dearomatization | Cell Survival - drug effects | Antineoplastic Agents, Phytogenic - chemical synthesis | Pancreatic Neoplasms - metabolism | Stereoisomerism | Humans | Molecular Conformation | Pancreatic Neoplasms - pathology | Antineoplastic Agents, Phytogenic - chemistry | Crystallography, X-Ray | Biological Products - pharmacology | Biological Products - chemical synthesis | Biological Products - chemistry | Bridged-Ring Compounds - chemistry | Bridged-Ring Compounds - pharmacology | Cell Line, Tumor | Antineoplastic Agents, Phytogenic - pharmacology | Bridged-Ring Compounds - chemical synthesis | Chemotherapy | Nuclear nonproliferation | Pancreatic cancer | Analysis | Cancer | Deprivation | Natural products | Tumor cell lines | Biological activity | Index Medicus | Full Paper | Full Papers
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14. Full Text Synthesis of guggulsterone derivatives as potential anti-austerity agents against PANC-1 human pancreatic cancer cells
by Kohyama, Aki and Yokoyama, Rei and Dibwe, Dya Fita and El-Mekkawy, Sahar and Meselhy, Meselhy R and Awale, Suresh and Matsuya, Yuji
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2020, Volume 30, Issue 7, pp. 126964 - 126964
Steroid | Guggulsterone | Preferential cytotoxicity | Pancreatic cancer | PANC-1 | Antiausterity agent | Drug discovery | Index Medicus
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15. Full Text A Triterpene Lactone fromCallistemon citrinusInhibits the PANC-1 Human Pancreatic Cancer Cells Viability through Suppression of Unfolded Protein Response
by Tawila, Ahmed M and Sun, Sijia and Kim, Min Jo and Omar, Ashraf M and Dibwe, Dya Fita and Awale, Suresh
Chemistry & biodiversity, ISSN 1612-1872, 10/2020, Volume 17, Issue 10
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology
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16. Full Text Muchimangins A–D: novel diphenylmethyl-substituted xanthones from Securidaca longepedunculata
by Dibwe, Dya Fita and Awale, Suresh and Kadota, Shigetoshi and Tezuka, Yasuhiro
Tetrahedron letters, ISSN 0040-4039, 11/2012, Volume 53, Issue 46, pp. 6186 - 6190
Xanthone | Preferential cytotoxicity | Congolese medicinal plant | Securidaca longepedunculata | Pancreatic cancer | Medicine, Botanic | Medicine, Herbal | Human | Oxygenated | Biotechnology | Cell death | Roots | Tetrahedrons | Nutrients | Cancer
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17. Full Text A triterpene lactone from Callistemon citrinus inhibits the PANC‐1 human pancreatic cancer cells viability via suppression of unfolded protein response
by Awale, Suresh and Tawila, Ahmed and Sun, Sijia and Kim, Min Jo and Omar, Ashraf and Dibwe, Dya Fita and Kim, Min Jo
Chemistry & biodiversity, ISSN 1612-1872, 08/2020
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18. Full Text Discovery of potential antiausterity agents from the Japanese cypress Chamaecyparis obtusa
by Dibwe, Dya Fita and Sun, Sijia and Ueda, Jun-ya and Balachandran, Chandrasekar and Matsumoto, Kinzo and Awale, Suresh
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 11/2017, Volume 27, Issue 21, pp. 4898 - 4903
Chamaecyparis obtusa | Antiausterity agents | Autophagy | Pancreatic cancer | PANC-1 | Sesquiterpenes - isolation & purification | TOR Serine-Threonine Kinases - metabolism | Humans | Molecular Conformation | Terpenes - toxicity | Cyclodecanes - chemistry | Autophagy - drug effects | Chamaecyparis - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Terpenes - chemistry | Drug Evaluation, Preclinical | Proto-Oncogene Proteins c-akt - metabolism | Chamaecyparis - metabolism | Sesquiterpenes - chemistry | Terpenes - isolation & purification | Magnetic Resonance Spectroscopy | Cyclodecanes - toxicity | Antineoplastic Agents, Phytogenic - chemistry | Antineoplastic Agents, Phytogenic - toxicity | Cell Line, Tumor | Sesquiterpenes - toxicity | Cyclodecanes - isolation & purification | Microscopy, Fluorescence | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Antineoplastic Agents, Phytogenic - isolation & purification | Drug Screening Assays, Antitumor | Drug discovery | Cell death | Sesquiterpenes | Index Medicus
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19. Full Text Design and synthesis of functionalized coumarins as potential anti-austerity agents that eliminates cancer cells' tolerance to nutrition starvation
by Awale, Suresh and Okada, Takahiro and Dibwe, Dya Fita and Maruyama, Takahiro and Takahara, Satoyuki and Okada, Takuya and Endo, Satoshi and Toyooka, Naoki
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 07/2019, Volume 29, Issue 14, pp. 1779 - 1784
Antiausterity agent | Preferential cytotoxicity | Drug discovery | Coumarin | Pancreatic cancer | PANC-1 | Starvation | Nutrition | Cell death | Cancer cells | Coumarins | Index Medicus
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20. Full Text Decrease in endogenous brain allopregnanolone induces autism spectrum disorder (ASD)-like behavior in mice: A novel animal model of ASD
by Ebihara, Ken and Fujiwara, Hironori and Awale, Suresh and Dibwe, Dya Fita and Araki, Ryota and Yabe, Takeshi and Matsumoto, Kinzo
Behavioural brain research, ISSN 0166-4328, 09/2017, Volume 334, pp. 6 - 15
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