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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2005, Volume 102, Issue 10, pp. 3587 - 3592
Journal Article
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 08/2011, Volume 21, Issue 15, pp. 4436 - 4440
A potent series of inhibitors against the B-Raf super(V600E kinase have been developed that show excellent activity in cellular assays and good oral... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 8, pp. 2773 - 2778
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2008, Volume 105, Issue 8, p. 2773
  Analysis of the x-ray crystal structure of mono-substituted acetylenic thienopyrimidine 6 complexed with the ErbB family enzyme ErbB-4 revealed a covalent... 
Enzymes | Molecular structure | Kinases | Chemical compounds | Adenosine triphosphatase
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2001, Volume 44, Issue 25, pp. 4339 - 4358
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2013, Volume 4, Issue 3, pp. 358 - 362
Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-Raf(v600E) mutated enzyme has been observed in a number of human... 
MAP kinase | melanoma | GSK2118436 | B-Raf | dabrafenib | TRIAL | CHEMISTRY, MEDICINAL | BRAF | MUTATIONS
Journal Article
Science, ISSN 0036-8075, 1/2001, Volume 291, Issue 5501, pp. 134 - 137
Most traditional cytotoxic anticancer agents ablate the rapidly dividing epithelium of the hair follicle and induce alopecia (hair loss). Inhibition of... 
Hair | Alopecia | Epithelial cells | Scalp | Cell cycle | Antineoplastics | Rats | Atoms | Reports | Hair follicles | Cyclins | APOPTOSIS | ACTIVATION | DESIGN | PROTECTION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | GROWTH | RECEPTOR | CYCLIN-DEPENDENT KINASE | CELL-CYCLE | 1,25-DIHYDROXYVITAMIN D-3 | Phosphorylation | Cyclin-Dependent Kinases - metabolism | Apoptosis - drug effects | Humans | Indoles - chemical synthesis | Transplantation, Heterologous | Enzyme Inhibitors - chemical synthesis | Antineoplastic Agents - toxicity | Cyclin-Dependent Kinase 2 | Enzyme Inhibitors - chemistry | Cytoprotection - drug effects | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | DNA - biosynthesis | Indoles - pharmacology | Cyclin-Dependent Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Animals, Newborn | Cell Line | Epithelium - drug effects | Etoposide - toxicity | CDC2-CDC28 Kinases | Sulfonamides - chemistry | Retinoblastoma Protein - metabolism | Alopecia - prevention & control | Enzyme Inhibitors - pharmacology | Mice, SCID | Sulfonamides - pharmacology | Doxorubicin - toxicity | Antineoplastic Combined Chemotherapy Protocols - toxicity | Hair Follicle - drug effects | Sulfonamides - chemical synthesis | Hair Follicle - cytology | Animals | Scalp - transplantation | Alopecia - chemically induced | Cyclophosphamide - toxicity | Mice | Cell Cycle - drug effects | Indoles - chemistry | Prevention | Adverse and side effects | Chemotherapy | Drug therapy | Cancer | Rodents | cyclin-dependent kinase inhibitors | Cdk2 kinase | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 5, pp. 1332 - 1336
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2011, Volume 21, Issue 15, pp. 4436 - 4440
A potent series of inhibitors against the B-Raf kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in... 
Thiazole | Sulfonamide | B-RafV600E
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 4, pp. 1177 - 1182
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 3, pp. 976 - 980
Journal Article