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PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0148764 - e0148764
VTX-2337 (USAN: motolimod) is a selective toll-like receptor 8 (TLR8) agonist, which is in clinical development as an immunotherapy for multiple oncology... 
HEAD | ENHANCE | NK CELLS | CANCER CELLS | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | CRYSTALS | GENERATION | TUMORS | CD8(+) T-CELLS | NALP3 INFLAMMASOME | Neoplasms - metabolism | Leukocytes, Mononuclear - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Macaca fascicularis | Caspase 1 - metabolism | Male | Receptors, IgG - metabolism | Carrier Proteins - agonists | Lymphocyte Activation - immunology | Neoplasms - genetics | Leukocytes, Mononuclear - immunology | Killer Cells, Natural - immunology | Female | Interleukin-1beta - biosynthesis | Disease Models, Animal | Toll-Like Receptor 8 - agonists | Leukocytes, Mononuclear - drug effects | Benzazepines - pharmacology | Cell Degranulation - immunology | Interleukin-18 - biosynthesis | Animals | Benzazepines - therapeutic use | Lymphocyte Activation - drug effects | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Cytotoxicity, Immunologic - immunology | Cell Degranulation - drug effects | Physiological aspects | Toll-like receptors | Killer cells | Genetic aspects | Research | Immunotherapy | Toxicity | Cytotoxicity | Stimulation | Activation | Lymphocytes T | Monkeys | Cancer therapies | Caspase-1 | Metastases | NKG2 antigen | Cell activation | Epidermal growth factor | Lymphocytes | Rodents | Biocompatibility | Neck | Natural killer cells | Antibody-dependent cell-mediated cytotoxicity | Squamous cell carcinoma | Cytokines | Dendritic cells | Tumor cells | Caspase | T cell receptors | Tumor necrosis factor-α | Patients | Interleukin 18 | Medicine | Monocytes | Complement activation | Pyrin protein | Womens health | γ-Interferon | Monoclonal antibodies | Ligands | Lymphomas | Pharmaceuticals | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e58164 - e58164
Journal Article
OncoImmunology, ISSN 2162-4011, 05/2016, Volume 5, Issue 5, pp. e1126037 - e1126037
A novel approach to immunotherapy is the activation of toll-like receptor 8 (TLR8). Motolimod, a selective TLR8 agonist can act in concert with approved... 
CELLS | TLR8 | IMMUNOLOGY | ONCOLOGY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 10, pp. 2442 - 2450
Purpose: As Toll-like receptors (TLR) are key mediators of immune responses, TLR agonists may be important for augmenting the efficacy of therapies for... 
HEAD | II MULTICENTER | SOLID TUMORS | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | OPEN-LABEL | TOXICITY | ANTIBODY CETUXIMAB | NECK-CANCER | EGFR | CHEMOTHERAPY | Carcinoma, Squamous Cell - blood | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Benzazepines - adverse effects | Carcinoma, Squamous Cell - genetics | Humans | Middle Aged | Antineoplastic Combined Chemotherapy Protocols - adverse effects | Neoplasm Recurrence, Local - drug therapy | Male | Drug-Related Side Effects and Adverse Reactions - pathology | Neoplasm Recurrence, Local - pathology | Neoplasm Metastasis | Squamous Cell Carcinoma of Head and Neck | Antibodies, Monoclonal, Humanized - administration & dosage | Head and Neck Neoplasms - blood | Adult | Female | Antibodies, Monoclonal, Humanized - adverse effects | Head and Neck Neoplasms - drug therapy | Disease-Free Survival | Carcinoma, Squamous Cell - drug therapy | Toll-Like Receptor 8 - genetics | Cetuximab - administration & dosage | Head and Neck Neoplasms - genetics | Aged | Benzazepines - administration & dosage | Killer Cells, Natural - metabolism | Drug-Related Side Effects and Adverse Reactions - classification | Toxicity | Metastasis | Metastases | Anticancer properties | Proteins | Receptors | Safety engineering | Design standards | Toll-like receptors | Bioindicators | Neck | Natural killer cells | Squamous cell carcinoma | Head | Statistical analysis | Immune response | Cytokines | Dendritic cells | Pharmacology | Disease control | Patients | Immune systems | Monocytes | Experimental design | Biomarkers | Antitumor activity | Cancer | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 2, pp. 499 - 509
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 8/2013, Volume 62, Issue 8, pp. 1347 - 1357
Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that prolongs survival in the treatment for head and neck cancer (HNC), but... 
Immunology | Medicine & Public Health | VTX-2337 | Immunotherapy | Oncology | Cancer Research | TLR8 | Head and neck cancer | Cetuximab | ADCC | IMMUNITY | IFN-GAMMA PRODUCTION | MECHANISMS | IMMUNOLOGY | IMIQUIMOD | BLIND | TOLL-LIKE | NK CELLS | ONCOLOGY | CARCINOMA | AGONIST | Tumor Necrosis Factor-alpha - metabolism | Antigens, CD - immunology | Immunoglobulins - immunology | Membrane Glycoproteins - metabolism | Coculture Techniques | Dendritic Cells - immunology | Humans | Antibody-Dependent Cell Cytotoxicity - immunology | Interferon-gamma - metabolism | Head and Neck Neoplasms - metabolism | Antigens, CD - metabolism | Immunoglobulins - metabolism | Toll-Like Receptor 8 - immunology | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Antibodies, Monoclonal, Humanized - pharmacology | Benzazepines - immunology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Killer Cells, Natural - immunology | Antineoplastic Agents - pharmacology | Interleukin-12 Subunit p40 - immunology | Membrane Glycoproteins - immunology | B7-2 Antigen - immunology | Dendritic Cells - metabolism | Toll-Like Receptor 8 - agonists | Interleukin-12 Subunit p40 - metabolism | Receptor, Epidermal Growth Factor - immunology | Enzyme-Linked Immunosorbent Assay | Antineoplastic Agents - immunology | B7-1 Antigen - immunology | Cells, Cultured | B7-1 Antigen - metabolism | Benzazepines - pharmacology | Head and Neck Neoplasms - pathology | B7-2 Antigen - metabolism | Head and Neck Neoplasms - immunology | Cross-Priming - immunology | Interferon-gamma - immunology | Cell Line, Tumor | Killer Cells, Natural - metabolism | Antibodies, Monoclonal, Humanized - immunology | Antibody-Dependent Cell Cytotoxicity - drug effects | CD8-Positive T-Lymphocytes - immunology | Toll-Like Receptor 8 - metabolism | Index Medicus | Head and Neck Cancer
Journal Article
Journal Article
Journal Article
Immunity, Inflammation and Disease, ISSN 2050-4527, 03/2016, Volume 4, Issue 1, pp. 45 - 51
The manuscript describes the results of a pharmacology study that was performed to (1) determine the potential efficacy of a novel TLR 8 agonist for the... 
nasal congestion | ragweed | rhinitis | dog model | rhinometry | toll‐like receptor | Allergic | Toll‐like receptor | Nasal congestion | Rhinitis | Dog model | Rhinometry | Ragweed
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 08/2013, Volume 62, Issue 8, p. 1347
  Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that prolongs survival in the treatment for head and neck cancer (HNC), but... 
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 08/2013, Volume 62, Issue 8, pp. 1347 - 1357
Background: Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that prolongs survival in the treatment for head and neck cancer... 
Journal Article
Cancer Immunology, Immunotherapy, ISSN 0340-7004, 08/2013, Volume 62, Issue 8, p. 1347
Cetuximab is an anti-epidermal growth factor receptor (EGFR) monoclonal antibody that prolongs survival in the treatment for head and neck cancer (HNC), but... 
Antimitotic agents | Killer cells | Care and treatment | Epidermal growth factor | Dendritic cells | Analysis | Monoclonal antibodies | Head and neck cancer | T cells | Antineoplastic agents | Cancer
Journal Article
Proceedings of SPIE, ISSN 0277-786X, 03/2003, Volume 4841, Issue 1, pp. 1657 - 1669
The DEIMOS spectrograph is a multi-object spectrograph being built for Keck II. DEIMOS was delivered in February 2002, became operational in May, and is now... 
Astronomical cameras | CCDs | Optical testing | Multi-object spectrographs | Flexure compensation | Astronomical spectrographs | Ground-based instrumentation | Mosaic detectors
Conference Proceeding
Journal of Immunology, ISSN 0022-1767, 03/2015, Volume 194, Issue 6, pp. 2786 - 2795
Journal Article