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Journal Article
Obesity, ISSN 1930-7381, 08/2018, Volume 26, Issue 8, pp. 1255 - 1260
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2009, Volume 4, Issue 4, pp. e5254 - e5254
textabstractBackground: This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the... 
parasite antibody | pruritus | myalgia | papule | drug combination | major clinical study | drug dose comparison | apical membrane antigen I | malaria falciparum | Plasmodium | Plasmodium falciparum | fatigue | double blind procedure | phase 1 clinical trial | drug fever | female | protozoal protein | immunology | clinical trial | apical membrane antigen 1 | lipid A | drug safety | malaria vaccine | article | immunogenicity | nausea | antibody response | adolescent | animal | injection site erythema | metabolism | adult | male | drug derivative | injection site swelling | gamma interferon | injection site pain | arthralgia | antibody detection | enzyme linked immunosorbent assay | immunological adjuvant | chloroquine | drug eruption | genetics | controlled clinical trial | ASO2A adjuvant | sporozoite | human | skin inflammation | parasite antigen | phase 2 clinical trial | drug megadose | parasitemia | low drug dose | middle aged | liposome | randomized controlled trial | controlled study | allele | saponin | drug efficacy | membrane protein | drug induced headache | malaise | NATURAL IMMUNE-RESPONSES | FALCIPARUM CIRCUMSPOROZOITE PROTEIN | IMMUNIZATION | SAFETY | FORMULATIONS | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | MONKEYS | NAIVE ADULTS | PRECLINICAL EVALUATION | IMMUNOGENICITY TRIAL | Malaria, Falciparum - prevention & control | Adjuvants, Immunologic - administration & dosage | Adjuvants, Immunologic - pharmacology | Antigens, Protozoan - immunology | Saponins - administration & dosage | Humans | Lipid A - analogs & derivatives | Middle Aged | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Malaria Vaccines - adverse effects | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Adult | Plasmodium falciparum - metabolism | Antigens, Protozoan - genetics | Protozoan Proteins - administration & dosage | Lipid A - administration & dosage | Double-Blind Method | Enzyme-Linked Immunosorbent Assay | Membrane Proteins - genetics | Membrane Proteins - immunology | Membrane Proteins - administration & dosage | Animals | Malaria Vaccines - administration & dosage | Adolescent | Alleles | Lipid A - pharmacology | Drug Combinations | Protozoan Proteins - immunology | Saponins - pharmacology | Antigens | Medical research | Malaria | Analysis | Medical societies | Vaccination | Malaria vaccine | Medicine, Experimental | Interferon | Vaccines | Biological response modifiers | Health care | Growth rate | Peptides | Goats | Homology | Parasites | Appropriate technology | Aquatic insects | Proteins | Confidence intervals | Biological effects | Pain | Lymphocytes | Mathematical models | Safety | Parasitemia | Recombinant | Formulations | Vector-borne diseases | Enzymes | Evaluation | Immune response | Effectiveness | Statistical analysis | Membrane proteins | Studies | Polymerase chain reaction | Mosquitoes | Population (statistical) | Immunogenicity | γ-Interferon | Light microscopy | Adults | Erythema
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2011, Volume 365, Issue 11, pp. 1004 - 1013
Journal Article
PLoS ONE, ISSN 1932-6203, 2009, Volume 4, Issue 12, pp. e8138 - 8138
A Plasmodium falciparum 3D7 strain Apical Membrane Antigen-1 (AMA1) vaccine, formulated with AS02A adjuvant, slowed parasite growth in a recent Phase 1/2a... 
IMMUNOGENICITY | INVASION | VACCINE CANDIDATE | INSTITUTE-OF-RESEARCH | SAFETY | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | BLOOD-STAGE MALARIA | MONKEYS | AMA-1 | CHILDREN | Immunoassay | Malaria, Falciparum - prevention & control | Vaccination | Molecular Sequence Data | Plasmodium falciparum - immunology | Malaria Vaccines - chemistry | Sequence Analysis, Protein | Antibody Specificity - immunology | Malaria Vaccines - immunology | Protozoan Proteins - chemistry | Disease Models, Animal | Amino Acid Sequence | Antibody Formation - immunology | Enzyme-Linked Immunosorbent Assay | Antibodies, Protozoan - immunology | Parasitemia - immunology | Parasitemia - complications | Recombinant Proteins - chemistry | Malaria, Falciparum - complications | Protein Folding | Animals | Aotus trivirgatus | Recombinant Proteins - immunology | Malaria, Falciparum - immunology | Titrimetry | Plasmodium falciparum - growth & development | Protozoan Proteins - immunology | Antigens | Usage | Wildlife conservation | Malaria | Antibodies | Vaccines | Viral antibodies | Plasmodium falciparum | Analysis | Primates | Rankings | Enzyme-linked immunosorbent assay | Substance abuse treatment | Growth rate | Erythrocytes | Fluorescence | Homology | Monkeys | Infections | Parasites | Proteins | Parasitic diseases | Parasitemia | Drug dosages | Protected animals | Recombinant | Formulations | Vector-borne diseases | Immunoglobulins | Disease control | Low level | Biological activity | Disease prevention | Dilution | Influenza
Journal Article
Malaria journal, ISSN 1475-2875, 01/2019, Volume 18, Issue 1, pp. 13 - 10
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79323
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2009, Volume 4, Issue 3, p. e4708
Journal Article
PLoS One, ISSN 1932-6203, 2013, Volume 8, Issue 2, p. e55571
BACKGROUND: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal... 
APICAL MEMBRANE ANTIGEN-1 | SPOROZOITE INOCULATION | VIRUS ANKARA | IMMUNIZATION | NEUTRALIZING ANTIBODIES | MULTIDISCIPLINARY SCIENCES | CIRCUMSPOROZOITE PROTEIN | DOUBLE-BLIND | NAIVE ADULTS | CYTOTOXIC T-LYMPHOCYTES | PHASE 2A TRIAL | Vaccines, DNA - genetics | Malaria, Falciparum - prevention & control | Antigens, Protozoan - immunology | Humans | Middle Aged | Vaccines, DNA - immunology | Male | Plasmodium falciparum - immunology | Protozoan Proteins - genetics | Young Adult | Malaria Vaccines - adverse effects | Plasmodium falciparum - genetics | Malaria Vaccines - immunology | Adult | Female | Antigens, Protozoan - genetics | Malaria Vaccines - therapeutic use | Membrane Proteins - genetics | Adenoviruses, Human - immunology | Membrane Proteins - immunology | Vaccines, DNA - therapeutic use | Malaria, Falciparum - parasitology | Interferon-gamma - immunology | Vaccines, DNA - adverse effects | Adolescent | Malaria, Falciparum - immunology | Adenoviruses, Human - genetics | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Protozoan Proteins - immunology | Malaria Vaccines - genetics | Antigens | Wildlife conservation | Malaria | Liver | Vaccination | Malaria vaccine | Vaccines | T cells | Plasmodium falciparum | Advertising executives | Mosquitoes | Control | Analysis | Adenoviruses | DNA | Bites and stings | Genetic aspects | Health aspects | Enzyme-linked immunosorbent assay | Flow cytometry | Animal models | Goats | CD8 antigen | Antibodies | Leukocytes (mononuclear) | Lymphocytes T | Parasites | Aquatic insects | Immunity | Immunity (cell-mediated) | Replicating | Acquired immune deficiency syndrome--AIDS | Sporozoites | Peripheral blood mononuclear cells | Deoxyribonucleic acid--DNA | Circumsporozoite protein | Expression vectors | Vector-borne diseases | Medical research | Immunization | Statistical analysis | Diarrhea | Membrane proteins | Cytometry | Plasmids | γ-Interferon | Interferon | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106241
Background: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP) and apical membrane... 
APICAL MEMBRANE ANTIGEN-1 | RESPONSES | IMMUNOGENICITY | PROTEIN | PROTECTION | LIVER STAGES | SAFETY | MULTIDISCIPLINARY SCIENCES | VACCINE | CANDIDATE | CD8(+) T-CELLS | Antigens, Protozoan - immunology | DNA - immunology | Humans | Malaria, Falciparum - pathology | DNA - administration & dosage | Membrane Proteins - immunology | Plasmodium falciparum - immunology | Epitopes - immunology | Membrane Proteins - administration & dosage | Malaria, Falciparum - parasitology | Interleukin-2 - immunology | Malaria Vaccines - administration & dosage | Interferon-gamma - immunology | Antigens, Protozoan - administration & dosage | Malaria Vaccines - immunology | Malaria, Falciparum - immunology | Tumor Necrosis Factor-alpha - immunology | Plasmodium falciparum - pathogenicity | Adult | Immunologic Memory | Protozoan Proteins - administration & dosage | Adenoviridae - immunology | CD8-Positive T-Lymphocytes - immunology | Protozoan Proteins - immunology | Infection | Plasmodium falciparum | Immunization | Malaria | Adenoviruses | DNA | Interferon | T cells | Health aspects | Antigenic determinants | CD8 antigen | Liver | Effector cells | Lymphocytes T | Infections | Vaccines | Immunity | Proteins | Immunology | Interleukin 2 | Lymphocytes | Plasmid DNA | Volunteers | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Circumsporozoite protein | Vector-borne diseases | Antigens | Medical research | Immunological memory | Memory cells | Priming | Epitopes | Tumor necrosis factor-α | Vectors (Biology) | Membrane proteins | Plasmids | γ-Interferon | Comparative analysis | Deoxyribonucleic acid
Journal Article