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Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7647, p. 676
Cancer stem cells (CSCs) have been hypothesized to represent the driving force behind tumour progression and metastasis, making them attractive cancer targets.... 
Colorectal cancer | Stem cells | Tumorigenesis | Metastasis | Tumors
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7413, pp. 660 - 664
Journal Article
Science, ISSN 0036-8075, 10/2009, Volume 326, Issue 5952, pp. 572 - 574
The Hedgehog (Hh) signaling pathway is inappropriately activated in certain human cancers, including medulloblastoma, an aggressive brain tumor. GDC-0449, a... 
Receptors | Relapse | Basal cell carcinoma | Medulloblastoma | Amino acids | Biopsies | Reports | Genetic mutation | Tumors | Resistance mechanisms | Cancer | PROTEIN-COUPLED RECEPTORS | CYCLOPAMINE | CANCER | MULTIDISCIPLINARY SCIENCES | Anilides - therapeutic use | Receptors, G-Protein-Coupled - metabolism | Humans | Brain Neoplasms - pathology | Hedgehog Proteins - metabolism | Molecular Sequence Data | Drug Resistance, Neoplasm | Antineoplastic Agents - therapeutic use | Mutation, Missense | Antineoplastic Agents - metabolism | Neoplasm Metastasis | Hedgehog Proteins - genetics | Medulloblastoma - pathology | Smoothened Receptor | Veratrum Alkaloids - pharmacology | Antineoplastic Agents - pharmacology | Patched Receptors | Medulloblastoma - genetics | Mutant Proteins - antagonists & inhibitors | Pyridines - therapeutic use | Amino Acid Sequence | Signal Transduction | Anilides - metabolism | Brain Neoplasms - genetics | Receptors, Cell Surface - metabolism | Mutant Proteins - metabolism | Hedgehog Proteins - antagonists & inhibitors | Brain Neoplasms - drug therapy | Cinnamates - pharmacology | Animals | Pyridines - metabolism | Mutant Proteins - chemistry | Anilides - pharmacology | Receptors, G-Protein-Coupled - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Mice | Pyridines - pharmacology | Receptors, G-Protein-Coupled - genetics | Medulloblastoma - drug therapy | Receptors, G-Protein-Coupled - chemistry | Amino Acid Substitution | Receptors, Cell Surface - genetics | Gene mutations | Development and progression | Genetic aspects | Diagnosis | Drug resistance | Identification and classification | Signal transduction | Genotype & phenotype | Inhibitor drugs | Cellular biology | Brain cancer | Mutation | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7647, pp. 676 - 680
Journal Article
Cancer Research, ISSN 0008-5472, 01/2011, Volume 71, Issue 2, pp. 435 - 444
Journal Article
Nature, ISSN 0028-0836, 10/2018, Volume 562, Issue 7727, pp. 429 - 433
Despite the efficacy of Hedgehog pathway inhibitors in the treatment of basal cell carcinoma (BCC)(1) , residual disease persists in some patients and may... 
STEM-CELLS | VISMODEGIB | HAIR FOLLICLE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | KERATINOCYTES | OPEN-LABEL | SKIN | DIFFERENTIATION | CARCINOMA | BASAL-CELL | Anilides - therapeutic use | Skin Neoplasms - drug therapy | Humans | Epidermal Cells - metabolism | Hedgehog Proteins - metabolism | Smoothened Receptor - metabolism | Stem Cells - metabolism | Hair Follicle - pathology | Epidermal Cells - drug effects | Pyridines - therapeutic use | Skin Neoplasms - pathology | Pyridines - administration & dosage | Carcinoma, Basal Cell - pathology | Hedgehog Proteins - antagonists & inhibitors | Carcinoma, Basal Cell - metabolism | Skin Neoplasms - metabolism | Hair Follicle - drug effects | Animals | Wnt Signaling Pathway - drug effects | Anilides - administration & dosage | Signal Transduction - drug effects | Cell Differentiation - drug effects | Hair Follicle - metabolism | Anilides - pharmacology | Carcinoma, Basal Cell - drug therapy | Epidermal Cells - pathology | Stem Cells - drug effects | Stem Cells - pathology | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Basal cell carcinoma | Enzyme inhibitors | Research | Genetic transcription | Oncology, Experimental | Cancer | Chromatin | Transcription factors | Substance abuse treatment | Wnt protein | Medical treatment | Genomics | Stem cell transplantation | Epidermis | Activation | Genomes | Gene expression | Enhancers | Inhibitors | Transcription activation | Stem cells | Tumors | Index Medicus
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Discovery, ISSN 2159-8274, 07/2012, Volume 2, Issue 7, pp. 638 - 651
Journal Article