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CHEMICAL & ENGINEERING NEWS, ISSN 0009-2347, 10/2015, Volume 93, Issue 39, pp. 22 - 22
Journal Article
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 03/2019, Volume 316, Issue 3, pp. E397 - E409
Journal Article
Molecular Metabolism, ISSN 2212-8778, 12/2018, Volume 18, pp. 1 - 2
Journal Article
Nature Medicine, ISSN 1078-8956, 12/2014, Volume 21, Issue 1, pp. 27 - 36
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 10/2017, Volume 19, Issue 10, pp. 1436 - 1445
Aims To investigate the pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of RG7697, a dual glucose‐dependent insulinotropic... 
RG7697, RO6811135 | NNC0090‐2746 | pharmacodynamics | safety | pharmacokinetics | type 2 diabetes mellitus | dual GIP/GLP‐1 agonist | NNC0090-2746 | dual GIP/GLP-1 agonist | ACTIVATION | RO6811135 | RECEPTOR AGONISTS | QTC INTERVAL | GIP | RESPONSES | GLUCAGON-LIKE PEPTIDE-1 | BIOLOGY | ENDOCRINOLOGY & METABOLISM | SECRETION | GASTRIC-INHIBITORY POLYPEPTIDE | RG7697 | ASSOCIATION | Gastric Inhibitory Polypeptide - agonists | Hypoglycemic Agents - pharmacokinetics | Double-Blind Method | Humans | Middle Aged | Drugs, Investigational - pharmacokinetics | Male | Diabetes Mellitus, Type 2 - metabolism | Blood Glucose - drug effects | Dose-Response Relationship, Drug | Hypoglycemic Agents - administration & dosage | Glucagon-Like Peptide 1 - agonists | Drugs, Investigational - administration & dosage | Adult | Female | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Complications and side effects | Safety and security measures | Peptides | Low density lipoproteins | Glycosylated hemoglobin | Glucose | Dextrose | Appetite | Pharmacodynamics | Fasting | Polypeptides | Glucagon | Diabetes mellitus | Body weight | Diarrhea | Gastric emptying | Nausea | GIP protein | Hypoglycemia | Insulin | Immunological tolerance | Hemoglobin | Diabetes | Pharmacokinetics | Glucagon-like peptide 1
Journal Article
Diabetes, ISSN 0012-1797, 05/2013, Volume 62, Issue 5, pp. 1453 - 1463
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in... 
PPAR-ALPHA | BODY-WEIGHT | METABOLISM | FIBROBLAST-GROWTH-FACTOR-21 | PHARMACOLOGY | INCREASES ENERGY-EXPENDITURE | ENDOCRINOLOGY & METABOLISM | DEGRADATION | MICE | INSULIN SENSITIVITY | FGF21 | Obesity - drug therapy | Humans | Peptides - pharmacokinetics | Fibroblast Growth Factors - genetics | Male | Fibroblast Growth Factors - secretion | Obesity - blood | Anti-Obesity Agents - therapeutic use | Glucagon - agonists | Fibroblast Growth Factors - metabolism | Anti-Obesity Agents - pharmacokinetics | Peptides - chemical synthesis | Hepatocytes - secretion | Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Receptors, Glucagon - genetics | Hypoglycemic Agents - pharmacokinetics | Peptides - physiology | Rats | Hypoglycemic Agents - pharmacology | Mice, Knockout | Cross-Over Studies | Anti-Obesity Agents - chemical synthesis | Mice | Anti-Obesity Agents - pharmacology | Hepatocytes - pathology | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Molecular Targeted Therapy | Mice, Mutant Strains | HEK293 Cells | Adult | Female | Hepatocytes - drug effects | Recombinant Proteins - metabolism | Double-Blind Method | Cells, Cultured | Insulin Resistance | Receptors, Glucagon - metabolism | Recombinant Proteins - agonists | Glucagon - pharmacology | Obesity - metabolism | Diabetes Mellitus, Type 2 - blood | Animals | Fibroblast Growth Factors - blood | Hypoglycemic Agents - chemical synthesis | Glucagon - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Peptides - therapeutic use | Physiological aspects | Fibroblast growth factors | Research | Glucagon | Analysis | Original Research
Journal Article