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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2011, Volume 108, Issue 7, pp. 2909 - 2914
The dense collagen network in tumors significantly reduces the penetration and efficacy of nanotherapeutics. We tested whether losartan—a clinically approved... 
Nanoparticles | Receptors | Medical treatment | Collagens | Antineoplastics | Viruses | Dosage | Pancreatic neoplasms | Tumors | Cancer | Thrombospondin-1 | Drug delivery | Transport | Transforming growth factor β | Matrix modifier | INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | transforming growth factor beta | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | drug delivery | transport | BLOOD-FLOW | ANGIOTENSIN | CONVERTING-ENZYME-INHIBITORS | GROWTH-FACTOR-BETA | MOUSE MODEL | TYPE-1 RECEPTOR BLOCKADE | thrombospondin-1 | RENAL INJURY | matrix modifier | Immunohistochemistry | Skin Neoplasms - drug therapy | Fluorescence Recovery After Photobleaching | Humans | DNA Primers - genetics | Dose-Response Relationship, Drug | Pancreatic Neoplasms - drug therapy | Doxorubicin - analogs & derivatives | Polymerase Chain Reaction | Female | Collagen - biosynthesis | Losartan - pharmacokinetics | Doxorubicin - administration & dosage | Carcinoma - drug therapy | Nanotechnology - methods | Losartan - pharmacology | Mice, SCID | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Oncolytic Virotherapy - methods | Simplexvirus | Animals | Analysis of Variance | Mice | Drug Delivery Systems - methods | Drugs | Care and treatment | Drug delivery systems | Medical technology | Research | Properties | Vehicles | Medical laboratory technology | Collagen | Losartan | Nanotechnology | Biological Sciences | Physical Sciences | transforming growth factor β
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2012, Volume 109, Issue 38, pp. 15101 - 15108
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16618 - 16623
Although the role of TGF-ß in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this study,... 
Cell growth | Receptors | Perfusion | Collagens | Antineoplastics | Blood vessels | Metastasis | Tumors | Cancer | Apoptosis | Breast cancer | Drug delivery | Vessel normalization | CANCER-CELLS | COLLAGEN | METASTASIS | SOLID TUMORS | MULTIDISCIPLINARY SCIENCES | VESSEL MATURATION | breast cancer | drug delivery | DELIVERY | GROWTH-FACTOR-BETA | SOLUBLE BETAGLYCAN | vessel normalization | PROSTATE-CANCER | EXTRACELLULAR TRANSPORT | Antibodies, Neutralizing - administration & dosage | Doxorubicin - therapeutic use | Receptors, Transforming Growth Factor beta - genetics | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Breast Neoplasms - metabolism | Tissue Distribution | Antibodies, Neutralizing - immunology | Lung Neoplasms - secondary | Transforming Growth Factor beta - antagonists & inhibitors | Female | Antibiotics, Antineoplastic - pharmacokinetics | Protein-Serine-Threonine Kinases - metabolism | Transforming Growth Factor beta - immunology | Collagen Type I - metabolism | Protein-Serine-Threonine Kinases - genetics | Treatment Outcome | Signal Transduction - genetics | Breast Neoplasms - drug therapy | Blotting, Western | Doxorubicin - pharmacokinetics | Antibiotics, Antineoplastic - administration & dosage | Xenograft Model Antitumor Assays | Animals | Lung Neoplasms - prevention & control | Receptors, Transforming Growth Factor beta - metabolism | Signal Transduction - drug effects | Tumor Burden - drug effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Breast Neoplasms - pathology | Mice, Nude | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Transforming Growth Factor beta - metabolism | Biological Sciences | Physical Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2011, Volume 108, Issue 7, p. 2909
The dense collagen network in tumors significantly reduces the penetration and efficacy of nanotherapeutics. We tested whether losartan - a clinically approved... 
Proteins | Nanoscience | Protein synthesis | Pharmacology | Drug therapy | Tumors
Journal Article
Biophysical Journal, ISSN 0006-3495, 11/2010, Volume 99, Issue 10, p. 3119
  The interstitial matrix is comprised of cross-linked collagen fibers, generally arranged in nonisotropic orientations. Spatial alignment of matrix components... 
Proteins | Molecular physics | Anisotropy | Biophysics | Diffusion | Tumors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, p. 16618
  Although the role of TGF-β in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this... 
Proteins | Cell growth | Pharmacology | Breast cancer | Metastasis | Gene expression | Tumors
Journal Article
Nucleic Acids Res, ISSN 0305-1048, 03/2010, Volume 33, Issue (16) ; 2005
Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio RNA.... 
SACCHARIDES | SACCHAROSE | RNA | RESOLUTION | RIBOSE | CRYSTAL STRUCTURE | SULFUR | MATERIALS SCIENCE | IN VIVO | NUCLEIC ACIDS | NUCLEASES | OXYGEN | MODIFICATIONS | NUCLEOTIDES | THERMODYNAMICS | DNA | IN VITRO | ATOMS | RESIDUES | GEOMETRY
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 09/2012, Volume 109, Issue 38, p. 15101
  The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical... 
Human subjects | Cell growth | Collagen | Rodents | Mathematical models | Cells | Tumors
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 10/2012, Volume 109, Issue 41, pp. 16618 - 16623
Although the role of TGF-[beta] in tumor progression has been studied extensively, its impact on drug delivery in tumors remains far from understood. In this... 
Care and treatment | Carcinoma | Physiological aspects | Development and progression | Breast cancer | Genetic aspects | Metastasis | Research | Transforming growth factors | Health aspects | Cancer
Journal Article
Biophysical Journal, ISSN 0006-3495, 07/2009, Volume 97, Issue 1, p. 330
  Molecular cancer therapy relies on interstitial diffusion for drug distribution in solid tumors. A mechanistic understanding of how tumor components affect... 
Tissue | Chemotherapy | Rodents | Biophysics | Cancer | Tumors
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 08/2005, Volume 33, Issue 16, p. 5297
  Substitution of oxygen atoms by sulfur at various locations in the nucleic acid framework has led to analogs such as the DNA phosphorothioates and 4'-thio... 
Journal Article
01/2011, ISBN 9781124500386
Recent studies have shown that the inefficiency of nanotherapeutics in tumors can be attributed, in part, to transport hindrance posed by the vasculature, and... 
Studies | Biophysics | Chemical engineering | Biomedical engineering | Pharmaceuticals
Dissertation
02/2018
Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and... 
HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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