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Biotechnology Advances, ISSN 0734-9750, 11/2018, Volume 36, Issue 6, p. 1657
Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-related diseases. In addition, natural products are an interesting... 
Medicine | Proteins | Receptors | Natural products | Liver | Biological evolution | Ligands | Metabolic syndrome | Modulators | Metabolic disorders
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 02/2014, Volume 54, Issue 2, p. 367
  Agonists of liver X receptors (LXR) α and β are important regulators of cholesterol metabolism, but agonism of the LXRα subtype appears to cause hepatic... 
Ligands | Lipids | Metabolism | Chemical compounds | Cholesterol
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 12/2019, p. 112444
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 1, pp. 73 - 89
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite... 
Natural product | Nuclear receptor | Diabetes | Nutrition | PPAR gamma | INSULIN ACTION ENHANCER | NECROSIS-FACTOR-ALPHA | LOWERS BLOOD-PRESSURE | IMPROVES GLYCEMIC CONTROL | ADIPOCYTE DIFFERENTIATION | PHARMACOLOGY & PHARMACY | RED-CLOVER EXTRACT | GLUCOSE-UPTAKE | NF-KAPPA-B | LIVER-X-RECEPTOR | ADIPOSE-TISSUE | Biological Products - chemistry | Humans | PPAR gamma - agonists | Models, Molecular | Protein Binding | Biological Products - pharmacology | Molecular Structure | PPAR gamma - metabolism | Energy Metabolism - drug effects | DIO, diet-induced obesity | PPAR, peroxisome proliferator-activated receptor | TNF-α, tumor necrosis factor alpha | RXR, retinoid X receptor | CAP, c-Cbl-associated protein | DCM, dichloromethane | NF-κB, nuclear factor-kappaB | 9-(S)-HODE, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | AF-2, activation function-2 | Part of the Special Issue | MeOH, methanol | LDL, low-density lipoprotein | Cdk5, cyclin-dependent kinase 5 | DPP-4, dipeptidylpeptidase 4 | HUVEC, human umbilical vein endothelial cells | Glut4, glucose transporter type 4 | FDA, Food and Drug Administration | LBD, ligand-binding domain | EMA, European Medicines Agency | TCM, traditional Chinese medicine | PPRE, peroxisome proliferator response element | Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets | PDB, protein data bank | SPPARMs, selective PPARγ modulators | HDL, high-density lipoprotein | MAPK, mitogen-activated protein kinase
Journal Article