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Journal Article
Nature, ISSN 0028-0836, 11/2007, Volume 450, Issue 7170, pp. 712 - 716
Journal Article
Nature Communications, ISSN 2041-1723, 2015, Volume 6, Issue 1, pp. 7645 - 7645
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 11/2013, Volume 10, Issue 9, pp. 793 - 797
We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from the optimization of a previously... 
SRT1720 | SRT2104 | Imidazothiazole | Activator | SIRT1 | Sirtuin | CHEMISTRY, MEDICINAL
Journal Article
Nature, ISSN 0028-0836, 11/2007, Volume 450, Issue 7170, pp. 712 - 716
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+... 
Journal Article
Nature, ISSN 0028-0836, 11/2007, Volume 450, Issue 7170, pp. 712 - 716
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes. SIRT1, an NAD+... 
Journal Article
Dalton Transactions, ISSN 1477-9226, 12/2003, Issue 23, pp. 4482 - 4492
Template condensation between 2,6-dicarbonylpyridines and a tripodal tetramine tris(3-aminopropyl) amine in the presence of copper(II) or nickel(II) yielded... 
TEMPLATE SYNTHESIS | MOLECULAR-STRUCTURE | CRYSTAL-STRUCTURE | SIDE-CHAIN | STRUCTURAL ASPECTS | PENDANT COORDINATING 2-PYRIDYLMETHYL | POLYAZA MACROCYCLES | RING CONTRACTION | METAL-COMPLEXES | ZINC(II) COMPLEXES | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Science (New York, N.Y.), 03/2013, Volume 339, Issue 6124, p. 1216
Journal Article
01/2004
Unbridged cyclidene complexes adopt a variety of conformations, including saddle-shaped, planar and Z-shaped. The conformations preferences of cyclidenes are... 
Chemistry
Dissertation
06/2016
Docun t33-20/05/2016 Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The... 
METALLURGY | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS
Patent
Letters in Drug Design & Discovery, ISSN 1570-1808, 11/2013, Volume 10, Issue 9, pp. 793 - 797
We have identified SRT2104 (4) as the first direct synthetic SIRT1 activator clinical candidate. The compound was derived from the optimization of a previously... 
Journal Article
02/2017
PROVIDED HEREIN ARE NOVEL SIRTUIN-MODULATING COMPOUNDS AND METHODS OF USE THEREOF THE SIRTUIN-MODULATING COMPOUNDS MAY BE USED FOR INCREASING THE LIFESPAN OF A... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
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