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by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
BMC Cancer, ISSN 1471-2407, 07/2017, Volume 17, Issue 1, pp. 487 - 487
Journal Article
Lipids, ISSN 0024-4201, 4/2012, Volume 47, Issue 4, pp. 355 - 361
Endocannabinoids have been implicated in cancer development and cause heterogenous effects in tumor cells, by inducing apoptosis, reducing migration, causing... 
Neurochemistry | Cell proliferation | Nutrition | PC-3 cells | Fatty acid amide hydrolase | Medical Biochemistry | N -Oleoyl taurine | N -Acyl amino acids | Life Sciences | Medicinal Chemistry | Lipidology | N -Arachidonoyl taurine | Microbial Genetics and Genomics | Oleoyl taurine | PC‐3 cells | Arachidonoyl taurine | Acyl amino acids | N-oleoyl taurine | N-acyl amino acids | N-arachidonoyl taurine | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANANDAMIDE | ENDOCANNABINOID SYSTEM | IDENTIFICATION | OXIDATIVE-METABOLISM | ACYLTRANSFERASE | NUTRITION & DIETETICS | N-Arachidonoyl taurine | ACID AMIDE HYDROLASE | CHANNELS | N-Oleoyl taurine | GLYCINES | EXPRESSION | N-Acyl amino acids | Cannabinoid Receptor Modulators - pharmacology | Oxazines | Adenocarcinoma - pathology | Apoptosis - drug effects | Cell Count | Humans | Male | Arachidonic Acids - chemistry | Dose-Response Relationship, Drug | Prostate - pathology | Flow Cytometry | Prostate - drug effects | Taurine - chemistry | Prostatic Neoplasms - drug therapy | Cell Survival - drug effects | Prostatic Neoplasms - pathology | Taurine - analogs & derivatives | Adenocarcinoma - drug therapy | Arachidonic Acids - pharmacology | Xanthenes | Cannabinoid Receptor Modulators - chemistry | Cell Line, Tumor | Cell Proliferation - drug effects | Taurine - pharmacology | Cell Cycle - drug effects | Physiological aspects | Taurine | Development and progression | Research | Prostate cancer | Index Medicus | Biological Sciences | Molecular Genetics | Naturvetenskap | Biologiska vetenskaper | molekylärgenetik | Natural Sciences
Journal Article
Cancer Research, ISSN 0008-5472, 08/2010, Volume 70, Issue 15, pp. 6268 - 6276
Journal Article
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 19, p. 7734
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2013, Volume 12, Issue 24, pp. 3770 - 3780
Journal Article
BMC Genomics, ISSN 1471-2164, 03/2013, Volume 14, Issue 1, pp. 165 - 165
Journal Article
BMC Cancer, ISSN 1471-2407, 04/2008, Volume 8, Issue 1, pp. 87 - 87
Background: Colorectal cancer is one of the most common causes of cancer-related mortality. The disease is clinically and genetically heterogeneous though a... 
ALLELES | ONCOLOGY | ASSOCIATION SCAN | NEOPLASIA | RISK | MUTATIONS | KINDREDS | Genetic Predisposition to Disease | Sweden | Colorectal Neoplasms - genetics | Humans | Middle Aged | Female | Male | Aged | Genetic Linkage - genetics | Genome | Chromosomes, Human, Pair 3 - genetics | Usage | Colorectal cancer | Genetic aspects | Diagnosis | Research | Single nucleotide polymorphisms | Risk factors | Methods | Index Medicus
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2012, Volume 40, Issue 17, pp. 8440 - 8448
Journal Article
Lipids, ISSN 1558-9307, 2012, Volume 47, Issue 4, p. 355
Endocannabinoids have been implicated in cancer development and cause heterogenous effects in tumor cells, by inducing apoptosis, reducing migration, causing... 
Cell proliferation | Biological Sciences | Naturvetenskap | N-Arachidonoyl taurine | Biologiska vetenskaper | PC-3 cells | Fatty acid amide hydrolase | Natural Sciences | N-Oleoyl taurine | N-Acyl amino acids
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 02/2007, Volume 15, Issue 2, pp. 143 - 149
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7651, p. 508
Journal Article