Annual Review of Neuroscience, ISSN 0147-006X, 01/2018, Volume 41, p. 185
Understanding the biological basis for human-specific cognitive traits presents both immense challenges and unique opportunities. Although the question of what...
Autism | Transcription | Genomics | Gene regulation | Developmental psychology | Cognitive ability | Evolution | Developmental disabilities
Autism | Transcription | Genomics | Gene regulation | Developmental psychology | Cognitive ability | Evolution | Developmental disabilities
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2015, Volume 18, Issue 5, pp. 637 - 646
The human cerebral cortex depends for its normal development and size on a precisely controlled balance between self-renewal and differentiation of diverse...
NERVOUS-SYSTEM | HUMAN BRAIN | CORTICAL-NEURONS | MAMMALIAN CEREBRAL-CORTEX | NONCODING RNAS | OUTER SUBVENTRICULAR ZONE | PROJECTION NEURONS | RADIAL GLIA | EXPRESSION | NEUROSCIENCES | FERRET CORTEX | Basic Helix-Loop-Helix Transcription Factors - genetics | Species Specificity | Humans | Ependymoglial Cells - metabolism | Molecular Sequence Data | Gene Expression Profiling | RNA, Long Noncoding - genetics | Ferrets | Cerebral Cortex - cytology | Nerve Tissue Proteins - genetics | Sequence Homology, Nucleic Acid | Cerebral Cortex - metabolism | Sequence Alignment | Animals | Sequence Analysis, RNA | Cerebral Cortex - embryology | Gene Expression Regulation, Developmental | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Transcription, Genetic | Mice | Single-Cell Analysis | Neural Stem Cells - metabolism | Cerebral cortex | Brain research | Genetic research | Genetic aspects | Genetic transcription | Research | Neurogenesis
NERVOUS-SYSTEM | HUMAN BRAIN | CORTICAL-NEURONS | MAMMALIAN CEREBRAL-CORTEX | NONCODING RNAS | OUTER SUBVENTRICULAR ZONE | PROJECTION NEURONS | RADIAL GLIA | EXPRESSION | NEUROSCIENCES | FERRET CORTEX | Basic Helix-Loop-Helix Transcription Factors - genetics | Species Specificity | Humans | Ependymoglial Cells - metabolism | Molecular Sequence Data | Gene Expression Profiling | RNA, Long Noncoding - genetics | Ferrets | Cerebral Cortex - cytology | Nerve Tissue Proteins - genetics | Sequence Homology, Nucleic Acid | Cerebral Cortex - metabolism | Sequence Alignment | Animals | Sequence Analysis, RNA | Cerebral Cortex - embryology | Gene Expression Regulation, Developmental | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Transcription, Genetic | Mice | Single-Cell Analysis | Neural Stem Cells - metabolism | Cerebral cortex | Brain research | Genetic research | Genetic aspects | Genetic transcription | Research | Neurogenesis
Journal Article
Annual Review of Neuroscience, ISSN 0147-006X, 7/2018, Volume 41, Issue 1, pp. 185 - 206
Understanding the biological basis for human-specific cognitive traits presents both immense challenges and unique opportunities. Although the question of what...
enhancer | development | evolution | HARs | autism spectrum disorder | comparative genomics | ACCELERATED REGIONS | ULTRASONIC VOCALIZATION | NEUROSCIENCES | PITUITARY-ADENOMAS | BRAIN-SIZE | GENETIC-VARIATION | HUMAN GENOME | POSITIVE SELECTION | SEGMENTAL DUPLICATIONS | STRUCTURAL VARIATION | CEREBRAL CORTICAL SIZE | Human acts | Laws, regulations and rules | Genomics | Genetic research | Genetic aspects | Genetic transcription | Human behavior
enhancer | development | evolution | HARs | autism spectrum disorder | comparative genomics | ACCELERATED REGIONS | ULTRASONIC VOCALIZATION | NEUROSCIENCES | PITUITARY-ADENOMAS | BRAIN-SIZE | GENETIC-VARIATION | HUMAN GENOME | POSITIVE SELECTION | SEGMENTAL DUPLICATIONS | STRUCTURAL VARIATION | CEREBRAL CORTICAL SIZE | Human acts | Laws, regulations and rules | Genomics | Genetic research | Genetic aspects | Genetic transcription | Human behavior
Journal Article
Cell, ISSN 0092-8674, 10/2016, Volume 167, Issue 2, pp. 341 - 354.e12
Comparative analyses have identified genomic regions potentially involved in human evolution but do not directly assess function. Human accelerated regions...
Autism | ASD | HARs | Human Accelerated regions | Brain Evolution | noncoding | MOUSE-BRAIN | HUMAN GENOME | EVOLUTION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONS | GOLABI-BEHMEL-SYNDROME | HIGH-RESOLUTION MAP | GENETIC-VARIANTS | AUTISM SPECTRUM DISORDERS | CEREBRAL-CORTEX | CELL BIOLOGY | Autism Spectrum Disorder - genetics | Genetic Predisposition to Disease | Introns | Humans | Repressor Proteins - genetics | Mice, Transgenic | Cognition | Gene Dosage | Cerebral Cortex - metabolism | Homeodomain Proteins - genetics | Genetic Variation | Neurogenesis - genetics | Point Mutation | Animals | Regulatory Elements, Transcriptional | Social Behavior | Alleles | Mice | Genome, Human | Nuclear Proteins - genetics | Quantitative Trait Loci | Medical colleges | Chromatin | Genes | Genomics | Social aspects | Gene mutations | Multiprocessing | Analysis | Human evolution | Genetic research | Genetic aspects | Medical research | Medicine, Experimental
Autism | ASD | HARs | Human Accelerated regions | Brain Evolution | noncoding | MOUSE-BRAIN | HUMAN GENOME | EVOLUTION | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONS | GOLABI-BEHMEL-SYNDROME | HIGH-RESOLUTION MAP | GENETIC-VARIANTS | AUTISM SPECTRUM DISORDERS | CEREBRAL-CORTEX | CELL BIOLOGY | Autism Spectrum Disorder - genetics | Genetic Predisposition to Disease | Introns | Humans | Repressor Proteins - genetics | Mice, Transgenic | Cognition | Gene Dosage | Cerebral Cortex - metabolism | Homeodomain Proteins - genetics | Genetic Variation | Neurogenesis - genetics | Point Mutation | Animals | Regulatory Elements, Transcriptional | Social Behavior | Alleles | Mice | Genome, Human | Nuclear Proteins - genetics | Quantitative Trait Loci | Medical colleges | Chromatin | Genes | Genomics | Social aspects | Gene mutations | Multiprocessing | Analysis | Human evolution | Genetic research | Genetic aspects | Medical research | Medicine, Experimental
Journal Article
Neuron, ISSN 0896-6273, 09/2018, Volume 99, Issue 5, pp. 905 - 913.e7
Channelopathies are disorders caused by abnormal ion channel function in differentiated excitable tissues. We discovered a unique neurodevelopmental...
Outer Radial Glia | Polymicrogyria | Oromotor | Speech | NaV1.1 | Voltage-Gated Sodium Channel (VGSC) | NaV1.3 | SCN3A | Cortical Development | SCN1A | 1.1 | 1.3 | Megalencephaly - pathology | Megalencephaly - diagnostic imaging | NAV1.3 Voltage-Gated Sodium Channel - genetics | Humans | Middle Aged | Cerebral Cortex - pathology | Child, Preschool | Infant | Male | Cell Movement - physiology | HEK293 Cells | Adult | Female | Child | Megalencephaly - genetics | Language Development | Cells, Cultured | Polymicrogyria - pathology | Ferrets | Cerebral Cortex - diagnostic imaging | Animals | Pedigree | Adolescent | Cerebral Cortex - growth & development | Sodium Channels - genetics | Polymicrogyria - genetics | Polymicrogyria - diagnostic imaging | Fetus | Nervous system diseases | Neurosciences | Growth | Laws, regulations and rules | Pregnant women | Brain | Nuclear magnetic resonance--NMR | Leukocyte migration | Neurons | Channelopathy | Epilepsy | Fetuses | Genomes | Microcephaly | Subventricular zone | Progenitor cells | Convulsions & seizures | Stem cells | Neural stem cells | Sodium channels (voltage-gated) | Software | Mutation | Cell migration
Outer Radial Glia | Polymicrogyria | Oromotor | Speech | NaV1.1 | Voltage-Gated Sodium Channel (VGSC) | NaV1.3 | SCN3A | Cortical Development | SCN1A | 1.1 | 1.3 | Megalencephaly - pathology | Megalencephaly - diagnostic imaging | NAV1.3 Voltage-Gated Sodium Channel - genetics | Humans | Middle Aged | Cerebral Cortex - pathology | Child, Preschool | Infant | Male | Cell Movement - physiology | HEK293 Cells | Adult | Female | Child | Megalencephaly - genetics | Language Development | Cells, Cultured | Polymicrogyria - pathology | Ferrets | Cerebral Cortex - diagnostic imaging | Animals | Pedigree | Adolescent | Cerebral Cortex - growth & development | Sodium Channels - genetics | Polymicrogyria - genetics | Polymicrogyria - diagnostic imaging | Fetus | Nervous system diseases | Neurosciences | Growth | Laws, regulations and rules | Pregnant women | Brain | Nuclear magnetic resonance--NMR | Leukocyte migration | Neurons | Channelopathy | Epilepsy | Fetuses | Genomes | Microcephaly | Subventricular zone | Progenitor cells | Convulsions & seizures | Stem cells | Neural stem cells | Sodium channels (voltage-gated) | Software | Mutation | Cell migration
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 10/2018, Volume 87, p. 182
Neonates of all species, including foals, are highly susceptible to infection, and neutrophils play a crucial role in innate immunity to infection. Evidence...
Neonates | Chromatin | Immune response | Cytokines | Genes | Neutrophils | Innate immunity | Infections | Leukocytes (neutrophilic) | Gene expression | Immunity | Enhancers | Infectious diseases | Lysine | Epigenetics | Interferon | Age | Histone H3
Neonates | Chromatin | Immune response | Cytokines | Genes | Neutrophils | Innate immunity | Infections | Leukocytes (neutrophilic) | Gene expression | Immunity | Enhancers | Infectious diseases | Lysine | Epigenetics | Interferon | Age | Histone H3
Journal Article
NATURE GENETICS, ISSN 1061-4036, 07/2019, Volume 51, Issue 7, pp. 1092 - 1092
Autism spectrum disorder (ASD) affects up to 1 in 59 individuals(1). Genome-wide association and large-scale sequencing studies strongly implicate both common...
LOCALIZATION | DICARBOXYLIC AMINOACIDURIA | DE-NOVO MUTATIONS | RARE | PET-1 | GLUTAMATE | GENETICS & HEREDITY | RISK | TRANSCRIPTION FACTOR | GABA SYNTHESIS | ASSOCIATION | Haplotypes | ETS protein | USH2A protein | Transcription factors | Circuits | Genes | Genomics | Genomes | Gene expression | Gene sequencing | Autism | Missense mutation | Brain research | Mutation | Disruption | Females
LOCALIZATION | DICARBOXYLIC AMINOACIDURIA | DE-NOVO MUTATIONS | RARE | PET-1 | GLUTAMATE | GENETICS & HEREDITY | RISK | TRANSCRIPTION FACTOR | GABA SYNTHESIS | ASSOCIATION | Haplotypes | ETS protein | USH2A protein | Transcription factors | Circuits | Genes | Genomics | Genomes | Gene expression | Gene sequencing | Autism | Missense mutation | Brain research | Mutation | Disruption | Females
Journal Article
Hereditas, ISSN 0018-0661, 09/2009, Volume 146, Issue 4, pp. 180 - 182
Karyotypes can be difficult to create due to odd chromosome behaviors and high levels of adhesion between sex chromosomes. We have used live‐cell imaging and...
ARANEAE | TENSION | CHROMOSOMES | RELEASE | GENETICS & HEREDITY | Animals | Chromosome Banding | Sex Determination Processes | Mitosis | Karyotyping | Female | Male | Micromanipulation | Spiders - genetics | X Chromosome - ultrastructure | X Chromosome - genetics
ARANEAE | TENSION | CHROMOSOMES | RELEASE | GENETICS & HEREDITY | Animals | Chromosome Banding | Sex Determination Processes | Mitosis | Karyotyping | Female | Male | Micromanipulation | Spiders - genetics | X Chromosome - ultrastructure | X Chromosome - genetics
Journal Article
Chromosoma, ISSN 0009-5915, 10/2017, Volume 126, Issue 5, pp. 645 - 654
During meiosis I, homologous chromosomes join together to form bivalents. Through trial and error, bivalents achieve stable bipolar orientations (attachments)...
Life Sciences | Biochemistry, general | Human Genetics | Sex chromosomes | Latrodectus mactans | Spiders | Orientation stability | Meiosis | Developmental Biology | Cell Biology | Animal Genetics and Genomics | Eukaryotic Microbiology | SPERMATOGENESIS | ATTACHMENT | MICROTUBULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TENSION | SPINDLE | MITOSIS | EVOLUTION | MICROMANIPULATION | GENETICS & HEREDITY | REORIENTATION | Male | Chromosome Segregation | Animals | Black Widow Spider - genetics | Sex Chromosomes - genetics | Genetic research | Chromosomes | Poles | Sex | Cell division | Homology | Electron microscopy | Metaphase | X Chromosomes | Current distribution | Micromanipulation | Immunofluorescence | Anaphase
Life Sciences | Biochemistry, general | Human Genetics | Sex chromosomes | Latrodectus mactans | Spiders | Orientation stability | Meiosis | Developmental Biology | Cell Biology | Animal Genetics and Genomics | Eukaryotic Microbiology | SPERMATOGENESIS | ATTACHMENT | MICROTUBULES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TENSION | SPINDLE | MITOSIS | EVOLUTION | MICROMANIPULATION | GENETICS & HEREDITY | REORIENTATION | Male | Chromosome Segregation | Animals | Black Widow Spider - genetics | Sex Chromosomes - genetics | Genetic research | Chromosomes | Poles | Sex | Cell division | Homology | Electron microscopy | Metaphase | X Chromosomes | Current distribution | Micromanipulation | Immunofluorescence | Anaphase
Journal Article
Developmental and Comparative Immunology, ISSN 0145-305X, 10/2018, Volume 87, pp. 182 - 187
Neonates of all species, including foals, are highly susceptible to infection, and neutrophils play a crucial role in innate immunity to infection. Evidence...
ChIP-seq | Neonatal immunity | Histone modifications | Cytokines | Neutrophils | CELLS | IMMUNOLOGY | NEONATAL FOALS | IN-VITRO | FISHERIES | ZOOLOGY | RHODOCOCCUS-EQUI | INTERFERON-GAMMA | GENE-EXPRESSION | MICE | DIFFERENTIATION | INNATE IMMUNITY | AGE | Animals, Newborn | Reactive Oxygen Species - metabolism | Epigenesis, Genetic | Horses - genetics | Immunity, Innate - genetics | Neutrophils - immunology | Horses - metabolism | Signal Transduction - genetics | Promoter Regions, Genetic - genetics | Immunity, Innate - immunology | Signal Transduction - immunology | Animals | Horses - growth & development | Lysine - metabolism | Histones - metabolism | Horse Diseases - immunology | Methylation | Cytokines - genetics | Neutrophils - metabolism | Cytokines - immunology | Horse Diseases - genetics | Infants (Newborn) | Epigenetic inheritance | Medical colleges | Chromatin | Disease susceptibility | Lysine
ChIP-seq | Neonatal immunity | Histone modifications | Cytokines | Neutrophils | CELLS | IMMUNOLOGY | NEONATAL FOALS | IN-VITRO | FISHERIES | ZOOLOGY | RHODOCOCCUS-EQUI | INTERFERON-GAMMA | GENE-EXPRESSION | MICE | DIFFERENTIATION | INNATE IMMUNITY | AGE | Animals, Newborn | Reactive Oxygen Species - metabolism | Epigenesis, Genetic | Horses - genetics | Immunity, Innate - genetics | Neutrophils - immunology | Horses - metabolism | Signal Transduction - genetics | Promoter Regions, Genetic - genetics | Immunity, Innate - immunology | Signal Transduction - immunology | Animals | Horses - growth & development | Lysine - metabolism | Histones - metabolism | Horse Diseases - immunology | Methylation | Cytokines - genetics | Neutrophils - metabolism | Cytokines - immunology | Horse Diseases - genetics | Infants (Newborn) | Epigenetic inheritance | Medical colleges | Chromatin | Disease susceptibility | Lysine
Journal Article
Hereditas, ISSN 0018-0661, 09/2009, Volume 146, Issue 4, pp. 180 - 182
Journal Article
01/2013, ISBN 9781303649776
Separate domestication events and strong selective pressures have created diverse phenotypes among existing cattle populations; however, the genetic...
Animal Diseases | Genetics | Bioinformatics
Animal Diseases | Genetics | Bioinformatics
Dissertation
European Heart Journal Supplements, ISSN 1520-765X, 04/2011, Volume 13, Issue Suppl A, pp. A1 - A112
Journal Article
01/2013, ISBN 9781303649776, Volume 75, Issue 4
Separate domestication events and strong selective pressures have created diverse phenotypes among existing cattle populations; however, the genetic...
Book Chapter
Peptide Science, ISSN 0006-3525, 2006, Volume 84, Issue 4, pp. 414 - 420
Amino acids with N‐alkylaminooxy side chains have proven effective for the rapid synthesis of neoglycopeptides. Chemoselective reaction of reducing sugars with...
neoglycopeptide | Fmoc solid phase peptide synthesis | Neoglycopeptide | PEPTIDES | BIOPHYSICS | HYDROXAMIC ACIDS | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISACCHARIDE | NEOGLYCOPEPTIDES | Amino Acid Sequence | Glycopeptides - chemical synthesis | Fluorenes - chemistry | Peptides - chemical synthesis | Amino Acids - chemistry | Glycosylation | Molecular Structure | Chromatography, High Pressure Liquid
neoglycopeptide | Fmoc solid phase peptide synthesis | Neoglycopeptide | PEPTIDES | BIOPHYSICS | HYDROXAMIC ACIDS | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISACCHARIDE | NEOGLYCOPEPTIDES | Amino Acid Sequence | Glycopeptides - chemical synthesis | Fluorenes - chemistry | Peptides - chemical synthesis | Amino Acids - chemistry | Glycosylation | Molecular Structure | Chromatography, High Pressure Liquid
Journal Article
European Physical Journal C, ISSN 1434-6044, 2012, Volume 72, Issue 1, pp. 1849 - 61
Proton–proton collisions at $\sqrt{s}=7$ TeV and heavy ion collisions at $\sqrt{s_{NN}}=2.76$ TeV were produced by the LHC and recorded using the ATLAS...
Measurement Science and Instrumentation | Nuclear Physics, Heavy Ions, Hadrons | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | PHYSICS, PARTICLES & FIELDS | Collisions (Nuclear physics) | Protons | Heavy ions | Leptons | Particle collisions | Ionic collisions | Signatures | Atomic collisions | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Measurement Science and Instrumentation | Nuclear Physics, Heavy Ions, Hadrons | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | PHYSICS, PARTICLES & FIELDS | Collisions (Nuclear physics) | Protons | Heavy ions | Leptons | Particle collisions | Ionic collisions | Signatures | Atomic collisions | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Journal Article
European Physical Journal C, ISSN 1434-6044, 2012, Volume 72, Issue 3, pp. 1 - 46
Detailed measurements of the electron performance of the ATLAS detector at the LHC are reported, using decays of the Z, W and J/ψ particles. Data collected in...
Nuclear Physics, Heavy Ions, Hadrons | Measurement Science and Instrumentation | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | ELECTROMAGNETIC CALORIMETER | PHYSICS, PARTICLES & FIELDS | Measurement | Electromagnetism | Collisions (Nuclear physics) | Detectors | Electrons | Protons | Large Hadron Collider | Particle collisions | Linearity | Particle decay | Luminosity | Sensors | Electron energy | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | LUMINOSITY | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | PROBABILITY | ELECTRONS | PERFORMANCE | RESOLUTION | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Nuclear Physics, Heavy Ions, Hadrons | Measurement Science and Instrumentation | Nuclear Energy | Quantum Field Theories, String Theory | Physics | Elementary Particles, Quantum Field Theory | Astronomy, Astrophysics and Cosmology | ELECTROMAGNETIC CALORIMETER | PHYSICS, PARTICLES & FIELDS | Measurement | Electromagnetism | Collisions (Nuclear physics) | Detectors | Electrons | Protons | Large Hadron Collider | Particle collisions | Linearity | Particle decay | Luminosity | Sensors | Electron energy | Physics - High Energy Physics - Experiment | High Energy Physics - Experiment | LUMINOSITY | PHYSICS OF ELEMENTARY PARTICLES AND FIELDS | PROBABILITY | ELECTRONS | PERFORMANCE | RESOLUTION | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Journal Article