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Expert Opinion on Biological Therapy, ISSN 1471-2598, 12/2019, Volume 19, Issue 12, pp. 1223 - 1228
Journal Article
Pain medicine (Malden, Mass.), ISSN 1526-2375, 07/2019
To evaluate the long-term safety of NKTR-181, a novel mu-opioid receptor agonist that may have reduced human abuse potential, in patients with moderate to... 
Journal Article
Pain Medicine, ISSN 1526-2375, 09/2019
Abstract Objective To evaluate the human abuse potential, pharmacokinetics, pharmacodynamics, and safety of oral NKTR-181 (oxycodegol), a novel full mu-opioid... 
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2016, Volume 34, Issue 15_suppl, pp. 11545 - 11545
Journal Article
Cancer Research, ISSN 0008-5472, 10/2014, Volume 74, Issue 19 Supplement, pp. 5032 - 5032
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2014, Volume 32, Issue 15_suppl, pp. 3082 - 3082
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Radioactive half-life | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2016, Volume 22, Issue 3, pp. 680 - 690
Journal Article
Current medical research and opinion, 04/2019, p. 1
To prospectively evaluate the abuse potential of NKTR-181, a novel opioid analgesic, in two phase 3 clinical trials using a newly developed reporting system:... 
Journal Article
Pain, ISSN 0304-3959, 06/2019, Volume 160, Issue 6, pp. 1374 - 1382
NKTR-181, a new molecular entity, mu-opioid receptor agonist with an inherently slow rate of central nervous system (CNS) entry, was designed to provide... 
UNITED-STATES | MISUSE | SUMMIT-07 | NKTR-181 | Opioid | COCAINE | PREVALENCE | NEUROSCIENCES | Chronic pain | ADDICTION | CLINICAL NEUROLOGY | DRUG-ABUSE | Chronic low-back pain | THERAPY | FORMULATIONS | DISABILITY | DOPAMINE | ANESTHESIOLOGY | Research Paper
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 558 - 558
Background: While immune checkpoint blockade is a promising therapeutic approach, combination with agents that modulate complementary pathways may improve... 
Journal Article
Current Medical Research and Opinion, ISSN 0300-7995, 09/2019, Volume 35, Issue 9, pp. 1513 - 1522
Objective: To prospectively evaluate the abuse potential of NKTR-181, a novel opioid analgesic, in two phase 3 clinical trials using a newly developed... 
clinical trial | chronic pain | opioid abuse | drug accountability | opioid | potentially abuse-related events | Abuse potential | MEDICINE, RESEARCH & EXPERIMENTAL | MEDICINE, GENERAL & INTERNAL
Journal Article
Genes and Development, ISSN 0890-9369, 03/2001, Volume 15, Issue 6, pp. 672 - 686
Journal Article
The Journal of Immunology, ISSN 0022-1767, 08/2007, Volume 179, Issue 3, pp. 1872 - 1883
TNF is a pleiotropic cytokine required for normal development and function of the immune system; however, TNF overexpression also induces inflammation and is... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | TUMOR-NECROSIS-FACTOR | TRANSMEMBRANE TNF | IN-VIVO | TUBERCULOSIS INFECTION | ANTIBODY-INDUCED ARTHRITIS | IMMUNOLOGY | MONOCLONAL-ANTIBODIES | FACTOR ANTAGONISTS | FACTOR-ALPHA | Humans | Tumor Necrosis Factor-alpha - genetics | Immunity, Innate - genetics | Male | Recombinant Proteins - biosynthesis | Paracrine Communication - immunology | Arthritis, Experimental - pathology | Caspases - metabolism | Membrane Proteins - physiology | U937 Cells | Arthritis, Experimental - prevention & control | Inflammation Mediators - metabolism | Listeriosis - immunology | Female | Mice, Inbred DBA | Interleukin-8 - metabolism | Interleukin-8 - blood | Inflammation Mediators - physiology | Recombinant Proteins - antagonists & inhibitors | Listeriosis - genetics | Solubility | Arthritis, Experimental - immunology | Interleukin-8 - antagonists & inhibitors | Recombinant Proteins - pharmacology | Caspase Inhibitors | Membrane Proteins - biosynthesis | Animals | Membrane Proteins - antagonists & inhibitors | Listeriosis - pathology | Tumor Necrosis Factor-alpha - physiology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Inflammation Mediators | Paracrine Communication | Listeria Infections | Recombinant Proteins | Arthritis, Experimental | Tumor Necrosis Factor-alpha | Immunity, Natural | Interleukin-8 | Membrane Proteins | Life Sciences | Immunology | Caspases
Journal Article
Drug Discovery Today, ISSN 1359-6446, 2006, Volume 11, Issue 15, pp. 718 - 724
Journal Article
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