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glycogen phosphorylase (35) 35
animals (31) 31
elméleti orvostudományok (31) 31
orvostudományok (31) 31
glycogen (30) 30
index medicus (30) 30
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chemistry, medicinal (25) 25
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enzyme inhibitors - chemical synthesis (23) 23
enzyme inhibitors - chemistry (23) 23
binding (21) 21
enzyme inhibitors - pharmacology (20) 20
glucopyranosylidene-spiro-thiohydantoin (19) 19
glycogen phosphorylase - antagonists & inhibitors (18) 18
inhibitor (18) 18
organic chemistry (18) 18
derivatives (17) 17
glycogen phosphorylase, muscle form - antagonists & inhibitors (17) 17
structure-activity relationship (17) 17
glycogen phosphorylase, muscle form - metabolism (16) 16
glucose metabolism (15) 15
természettudományok (15) 15
glucose (14) 14
kémiai tudományok (14) 14
chemical sciences (12) 12
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molecular structure (12) 12
metabolism (11) 11
[chim.orga]chemical sciences/organic chemistry (10) 10
chemistry (10) 10
crystallography, x-ray (10) 10
glycogen phosphorylase - metabolism (10) 10
phosphorylase (10) 10
spirohydantoin (10) 10
targets (10) 10
glucose analog inhibitors (9) 9
inhibitors (9) 9
triazoles - chemistry (9) 9
models, molecular (8) 8
muscle, skeletal - enzymology (8) 8
triazoles - chemical synthesis (8) 8
acid (7) 7
analysis (7) 7
chemistry, multidisciplinary (7) 7
dextrose (7) 7
humans (7) 7
liver (7) 7
oxadiazoles - chemistry (7) 7
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type 2 diabetes (7) 7
amides (6) 6
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carbohydrates (6) 6
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glucose - analogs & derivatives (6) 6
glucose - chemistry (6) 6
hepatic glucose-production (6) 6
heterocyclic compounds (6) 6
liver - enzymology (6) 6
nucleosides (6) 6
protein binding (6) 6
triazoles - pharmacology (6) 6
type-2 diabetes therapy (6) 6
allosteric site (5) 5
amides - chemical synthesis (5) 5
beta-d-glucopyranosylamine (5) 5
c-nucleosides (5) 5
cyanides (5) 5
dose-response relationship, drug (5) 5
force-field (5) 5
glucose - pharmacology (5) 5
imidazole (5) 5
inhibition (5) 5
potential antidiabetic agents (5) 5
spiro compounds - chemistry (5) 5
sugars (5) 5
x-ray crystallography (5) 5
1,2,4-triazole (4) 4
[sdv.bbm.bc]life sciences [q-bio]/biochemistry, molecular biology/biomolecules [q-bio.bm] (4) 4
bioisosterism (4) 4
c-glucopyranosyl derivative (4) 4
cell research (4) 4
derivatives thereof (4) 4
diabetes (4) 4
enzyme inhibitors - metabolism (4) 4
glycogen - metabolism (4) 4
glycogen phosphorylase - chemistry (4) 4
glycogen phosphorylase inhibitor (4) 4
glycosylation (4) 4
heterocycles (4) 4
hypoglycemic agents - chemistry (4) 4
ischemic-injury (4) 4
liver - drug effects (4) 4
male (4) 4
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, ISSN 0021-8561, 06/2019, Volume 67, Issue 24, pp. 6884 - 6891
Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones were obtained via the corresponding 2-nitrophenyl glycosides obtained by two methods: (a) AgOTf-promoted... 
spiro-compound | FOOD SCIENCE & TECHNOLOGY | plant germination | ECD | MUSCLE | anomeric spirocycle | ECD-TDDFT | inhibition | benzo[b][1,4]thiazinone | TOFOGLIFLOZIN | PEPTIDES | AGRICULTURE, MULTIDISCIPLINARY | ASYMMETRIC EPOXIDATION | benzo[b][1,4]oxazinone | CHEMISTRY, APPLIED | GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN | DERIVATIVES | glycogen phosphorylase
Journal Article
Carbohydrate Research, ISSN 0008-6215, 01/2019, Volume 472, p. 33
Annulated C-[beta]-d-glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase.... 
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 08/2015, Volume 15, Issue 23, pp. 2390 - 2394
The major role of liver glycogen is to supply glucose to the circulation maintaining the normal blood glucose level. In muscle and liver the accumulation and... 
Blood glucose | Type 2 diabetes | Glycogen phosphorylase inhibitor | Insulin implant | Streptozotocin | SITE | CHEMISTRY, MEDICINAL | MUSCLE | CLAMP | METABOLISM | GLUCOSE | IN-VIVO | RESISTANCE | DERIVATIVES
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 01/2018, Volume 175, Issue 2, pp. 301 - 319
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 13, pp. 6116 - 6136
Epimeric series of aryl-substituted glucopyranosylidene-spiro-imidazolinones, an unprecedented new ring system, were synthesized from the corresponding Schiff... 
ANGSTROM RESOLUTION | CHEMISTRY, MEDICINAL | THIOHYDANTOIN | HETEROCYCLES | CHEMICAL-SHIFTS | ANALOGS | GLUCOSE | DERIVATIVES | SPIROHYDANTOIN | FUNCTIONALS | RANGE
Journal Article
Neurogastroenterology & Motility, ISSN 1350-1925, 11/2019
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e69420
Glycogen phosphorylase (GP) catalyzes the breakdown of glycogen and largely contributes to hepatic glucose production making GP inhibition an attractive target... 
CELLS | MULTIDISCIPLINARY SCIENCES | LIVER | MUSCLE | MICE | PROLIFERATION | UNCOUPLING PROTEIN-2 | GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN | CANCER | MTOR | REVEALS | Diabetes Mellitus, Experimental - drug therapy | Gene Expression - drug effects | TOR Serine-Threonine Kinases - metabolism | Diabetes Mellitus, Experimental - enzymology | Glucose - analogs & derivatives | Ion Channels - genetics | Male | Multiprotein Complexes - genetics | Mitochondrial Proteins - genetics | Mitochondrial Proteins - agonists | Enzyme Inhibitors - chemical synthesis | Mechanistic Target of Rapamycin Complex 2 | Urea - chemical synthesis | Multiprotein Complexes - metabolism | Glucose - chemical synthesis | Liver Glycogen - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | Liver Glycogen - antagonists & inhibitors | Mitochondrial Proteins - metabolism | Urea - analogs & derivatives | Diabetes Mellitus, Experimental - physiopathology | Glucose Tolerance Test | Liver - metabolism | Enzyme Inhibitors - pharmacology | Glucose - pharmacology | Glycogen Phosphorylase - metabolism | Animals | Ion Channels - metabolism | Oxygen Consumption - drug effects | Ion Channels - agonists | Mice, Obese | Multiprotein Complexes - agonists | Glycogen Phosphorylase - antagonists & inhibitors | Mice | Uncoupling Protein 2 | Urea - pharmacology | TOR protein | Mitochondrial uncoupling protein 2 | Animal models | Liver | Science | Biology | Glucose | Kinases | Proteins | Signal transduction | Mitochondria | Rodents | Hepatology | Oxidation | Inhibition | Glycogen | Diabetes mellitus | Oxygen consumption | Rapamycin | Metabolism | Phosphorylase | Glucose tolerance | Urea | Organic chemistry | Musculoskeletal system | Signaling | Sensitivity | Inhibitors | Glycogen phosphorylase | Sensitivity enhancement | Accommodation | Diabetes | Cancer
Journal Article
ISSN 1144-0546, 10/2018, Volume 42, Issue 21, pp. 17439 - 17446
A systematic study was performed on the preparation of unknown 2- C -(β- d -glucopyranosyl)pyrimidines. Pinner type cyclisation of O -perbenzylated C -(β- d... 
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 01/2018, Volume 42, Issue 21, pp. 17439 - 17446
A systematic study was performed on the preparation of unknown 2-C-(β-d-glucopyranosyl)pyrimidines. Pinner type cyclisation of O-perbenzylated... 
Pyrimidines | Galactosidase | Glucosidase | Cyanides | Catalysis
Journal Article
Beilstein Journal of Organic Chemistry, ISSN 1860-5397, 04/2015, Volume 11, Issue 1, pp. 499 - 503
Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished... 
Oxadiazole | Amidoxime | Carbodiimide | Glycogen phosphorylase | Vilsmeier salt | SITE | amidoxime | MUSCLE | CHEMISTRY, ORGANIC | HETEROCYCLES | oxadiazole | TARGETS | carbodiimide | EFFICIENT | DERIVATIVES | ACCESS | glycogen phosphorylase | Life Sciences | Organic chemistry | Biomolecules | Biochemistry, Molecular Biology | Chemical Sciences
Journal Article
Carbohydrate Research, ISSN 0008-6215, 01/2019, Volume 472, pp. 33 - 41
Annulated -β- -glucopyranosyl heterocycles were synthesized and tested as inhibitors of glycogen phosphorylase. 2-(β- -Glucopyranosyl)-1 -imidazo[4,5-... 
Fused azole | Inhibitor | C-glycosyl heterocycle | Imidazole | Glycogen phosphorylase | GLUCOSE ANALOG INHIBITORS | NUCLEOSIDES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCLE | CHEMISTRY, ORGANIC | IMIDAZOLES | REVEAL | CHEMISTRY, APPLIED | BINDING
Journal Article
Carbohydrate Research, ISSN 0008-6215, 11/2013, Volume 381, p. 187
Journal Article
New Journal of Chemistry, ISSN 1144-0546, 2018, Volume 42, Issue 21, pp. 17439 - 17446
A systematic study was performed on the preparation of unknown 2-C-(-d-glucopyranosyl)pyrimidines. Pinner type cyclisation of O-perbenzylated... 
C-NUCLEOSIDES | COMPLEX | ACID | GLYCOGEN-PHOSPHORYLASE-B | CRYSTAL | DERIVATIVES | CYANIDES | BINDING | CHEMISTRY, MULTIDISCIPLINARY | STRATEGIES
Journal Article
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 12/2015, Volume 6, Issue 12, pp. 1215 - 1219
Inhibition of glycogen phosphorylases may lead to pharmacological treatments of diseases in which glycogen metabolism plays an important role: first of all in... 
C-Glucopyranosyl derivative | imidazole | inhibitor | thiazole | pyrazole | isoxazole | glycogen phosphorylase | CYCLOADDITION REACTIONS | CHEMISTRY, MEDICINAL | GLYCOSYL | MUSCLE | CANCER | C-NUCLEOSIDES | KETONES | METABOLISM | TARGETS | GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN | BINDING
Journal Article
Carbohydrate Research, ISSN 0008-6215, 01/2015, Volume 402, pp. 245 - 251
Journal Article
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