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1. Full Text Identification of mNeonGreen as a pH‐Dependent, Turn‐On Fluorescent Protein Sensor for Chloride
by Tutol, Jasmine N and Kam, Hiu C and Dodani, Sheel C
ChemBioChem, ISSN 1439-4227, 07/2019
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2. Full Text Reaction-based small-molecule fluorescent probes for chemoselective bioimaging
by Chan, Jefferson and Dodani, Sheel C and Chang, Christopher J
Nature Chemistry, ISSN 1755-4330, 12/2012, Volume 4, Issue 12, pp. 973 - 984
The dynamic chemical diversity of elements, ions and molecules that form the basis of life offers both a challenge and an opportunity for study. Small-molecule... 
Diagnostic Imaging | Fluorescent Dyes - chemistry | Metals - chemistry | Oxidation-Reduction | Humans | Organic Chemicals - chemistry | Metals - analysis | Hypochlorous Acid - chemistry | Peroxynitrous Acid - chemistry | Organic Chemicals - analysis
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3. Full Text Front Cover: Identification of mNeonGreen as a pH‐Dependent, Turn‐On Fluorescent Protein Sensor for Chloride (ChemBioChem 14/2019)
by Tutol, Jasmine N and Kam, Hiu C and Dodani, Sheel C
ChemBioChem, ISSN 1439-4227, 07/2019, Volume 20, Issue 14, pp. 1727 - 1727
mNeonGreen: A bright idea for chloride: Chloride‐sensitive fluorescent proteins generated from natural and laboratory‐guided evolution have a characteristic... 
chloride binding pocket | protein engineering | fluorescent protein sensor | mNeonGreen | anions
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4. Full Text Identification of mNeonGreen as a pH‐Dependent, Turn‐On Fluorescent Protein Sensor for Chloride
by Tutol, Jasmine N and Kam, Hiu C and Dodani, Sheel C
ChemBioChem, ISSN 1439-4227, 07/2019, Volume 20, Issue 14, pp. 1759 - 1765
Chloride‐sensitive fluorescent proteins generated from laboratory evolution have a characteristic tyrosine residue that interacts with a chloride ion and... 
chloride binding pocket | protein engineering | mNeonGreen | fluorescent protein sensor | anions | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDICATOR | GREEN | BINDING | Proteins | Tyrosine | Optical properties | Crystals | Fluorescence | Chromophores | Hydrogen-ion concentration | Structure | Protein binding | Environmental engineering | Binding | Protein kinase A | pH effects | Chloride ions | Chloride | Mutagenesis | Chlorides | Green fluorescent protein | Phenols | Crystal structure
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5. Full Text Discovery and Characterization of a Naturally Occurring, Turn-On Yellow Fluorescent Protein Sensor for Chloride
by Tutol, Jasmine N and Peng, Weicheng and Dodani, Sheel C
Biochemistry, ISSN 0006-2960, 01/2019, Volume 58, Issue 1, pp. 31 - 35
Fluorescent proteins have been extensively engineered and applied as optical indicators for chloride in a variety of biological contexts. Surprisingly, given... 
MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDICATOR | DIVERSITY | CHANNELS | PROTON | EXCITED-STATE DYNAMICS | BINDING | Index Medicus
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6. Full Text Spectroscopic characterization and in silico modelling of polyvinylpyrrolidone as an anion-responsive fluorescent polymer in aqueous media
by Kam, Hiu C and Ranathunga, Dineli T. S and Payne, Ethan R and Smaldone, Ronald A and Nielsen, Steven O and Dodani, Sheel C
Supramolecular Chemistry, ISSN 1061-0278, 08/2019, Volume 31, Issue 8, pp. 514 - 522
Aqueous anion recognition has been a long-standing challenge in molecular recognition. The use of synthetic polymers is an emerging area of interest due to... 
fluorescent polymer | Aqueous anion recognition | molecular dynamics | Hofmeister series | polyvinylpyrrolidone | RECOGNITION | BEHAVIOR | ELECTROLYTE-SOLUTIONS | SOLVATION | CHEMISTRY, MULTIDISCIPLINARY | POLY(VINYLPYRROLIDONE) | HYDRATION | MOLECULAR-DYNAMICS SIMULATIONS | POLY(N-VINYLPYRROLIDONE) | BINDING | WATER
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7. Full Text Transcriptome Sequencing Identifies SPL7-Regulated Copper Acquisition Genes FRO4/FRO5 and the Copper Dependence of Iron Homeostasis in Arabidopsis
by Maria Bemal and David Casero and Vasantika Singh and Grandon T. Wilson and Arne Grande and Huijun Yang and Sheel Dodani and Matteo Pellegrini and Peter Huijser and Erin L. Connolly and Sabeeha S. Merchant and Ute Krämer
The Plant Cell, ISSN 1040-4651, 2/2012, Volume 24, Issue 2, pp. 738 - 761
The transition metal copper (Cu) is essential for all living organisms but is toxic when present in excess. To identify Cu deficiency responses... 
Genes | Plant roots | Superoxides | Homeostasis | Gene expression regulation | Plants | Copper | Chelates | Seedlings | Plant cells | SBP-DOMAIN | DNA-BINDING | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPRESSION PROFILES | POLLEN DEVELOPMENT | SACCHAROMYCES-CEREVISIAE | PLANT SCIENCES | CELL BIOLOGY | ARTIFICIAL MICRORNAS | FERRIC-CHELATE REDUCTASE | METAL HOMEOSTASIS | MULTICOPPER OXIDASE | ROOT ELONGATION | Arabidopsis Proteins - genetics | FMN Reductase - genetics | Plant Roots - metabolism | Plants, Genetically Modified - genetics | Transcriptome | RNA, Plant - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Iron - metabolism | Arabidopsis - metabolism | Gene Knockdown Techniques | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Plants, Genetically Modified - metabolism | Copper - metabolism | Gene Expression Regulation, Plant | High-Throughput Nucleotide Sequencing | Arabidopsis | Plant genetics | Physiological aspects | Genetic aspects | Genetic transcription | Research | Nucleotide sequencing | DNA sequencing
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8. Full Text A Targetable Fluorescent Sensor Reveals That Copper-Deficient SCO1 and SCO2 Patient Cells Prioritize Mitochondrial Copper Homeostasis
by Dodani, Sheel C and Leary, Scot C and Cobine, Paul A and Winge, Dennis R and Chang, Christopher J
Journal of the American Chemical Society, ISSN 0002-7863, 06/2011, Volume 133, Issue 22, pp. 8606 - 8616
We present the design, synthesis, spectroscopy, and biological applications of Mitochondrial Coppersensor-1 (Mito-CS1), a new type of targetable fluorescent... 
CELLULAR COPPER | BODIPY DYES | CYTOCHROME-C-OXIDASE | PROTEIN | ASSEMBLY FACTORS | CHEMISTRY | TARGETING MITOCHONDRIA | MUTATIONS | BINDING | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS | Fluorescent Dyes - chemistry | Membrane Proteins - genetics | Humans | Homeostasis | Molecular Imaging | Mitochondria - metabolism | Mitochondrial Proteins - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Copper - chemistry | Membrane Proteins - chemistry | Mitochondrial Proteins - metabolism | Copper - metabolism | HEK293 Cells | Mitochondrial Proteins - chemistry | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Mitochondria - chemistry | Fibroblasts - chemistry | Fibroblasts - metabolism | Copper compounds | Mitochondria | Chemical properties | Chemical synthesis | Analysis | Electric properties
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9. Copper is an endogenous modulator of neural circuit spontaneous activity
by Sheel C Dodani and Alana Firl and Jefferson Chan and Christine I Nam and Allegra T Aron and Carl S Onak and Karla M Ramos-Torres and Jaeho Paek and Corey M Webster and Marla B Feller and Christopher J Chang
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, p. 16280
  For reasons that remain insufficiently understood, the brain requires among the highest levels of metals in the body for normal function. The traditional... 
Oxidative stress | Metals | Copper | Metabolism
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10. Paralytic shellfish toxins inhibit copper uptake in Chlamydomonas reinhardtii
by Kathleen D Cusick and Randall K Wetzel and Steven C Minkin Jr and Sheel C Dodani and Steven W Wilhelm and Gary S Sayler
Environmental Toxicology and Chemistry, ISSN 0730-7268, 06/2013, Volume 32, Issue 6, p. 1388
  Paralytic shellfish toxins are secondary metabolites produced by several species of dinoflagellates and cyanobacteria. Known targets of these toxins, which... 
Shellfish | Plankton | Algae | Bacteria | Toxins | Copper | Gene expression
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11. Full Text A Turn-On Fluorescent Sensor for Detecting Nickel in Living Cells
by Dodani, Sheel C and He, Qiwen and Chang, Christopher J
Journal of the American Chemical Society, ISSN 0002-7863, 12/2009, Volume 131, Issue 50, pp. 18020 - 18021
We present the synthesis and properties of Nickelsensor-1 (NS1), a new water-soluble, turn-on fluorescent sensor that is capable of selectively responding to... 
CHEMOSENSORS | CRYSTAL-STRUCTURE | NIKR | ESCHERICHIA-COLI | BINDING-PROTEIN | CHEMISTRY | TRANSITION-METALS | CHEMISTRY, MULTIDISCIPLINARY | STRUCTURE/FUNCTION RELATIONSHIPS | NI2+ ION | AQUEOUS-SOLUTION | Boron Compounds - chemistry | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Cell Survival | Humans | Nickel - analysis | Spectrometry, Fluorescence | Acetates - chemical synthesis | Acetates - chemistry | Microscopy, Confocal | Boron Compounds - chemical synthesis | Cell Line, Tumor | Molecular Structure | Cell Culture Techniques | Optical properties | Analysis | Organometallic compounds | Fluorescence | Chromophores | Nickel | Chemical properties | Structure
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12. Full Text Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models
by Dodani, Sheel C and Kiss, Gert and Cahn, Jackson K. B and Su, Ye and Pande, Vijay S and Arnold, Frances H
Nature Chemistry, ISSN 1755-4330, 05/2016, Volume 8, Issue 5, pp. 419 - 425
The dynamic motions of protein structural elements, particularly flexible loops, are intimately linked with diverse aspects of enzyme catalysis. Engineering of... 
L-TRYPTOPHAN | MECHANISM | NITROTRYPTOPHAN FORMATION | CYTOCHROME-P450 ENZYMES | PEROXYNITRITE | PRODUCTS | BIOSYNTHESIS | FLEXIBILITY | HYDROXYLATION | CHEMISTRY, MULTIDISCIPLINARY | EPOXIDATION | Catalytic Domain | Markov Chains | Stereoisomerism | Tryptophan - chemistry | Crystallography, X-Ray | Molecular Dynamics Simulation | Cytochrome P-450 Enzyme System - chemistry | Heme - chemistry | Mutagenesis | Cytochrome P-450 Enzyme System - genetics | Protein Conformation | Streptomyces - enzymology | Catalysis | Histidine - chemistry | Enzymes | Nitration | Structural members | Regioselectivity | Computer simulation | Cytochrome P450 | Tryptophan | Molecular dynamics | Markov chains | Homology | Substrates | Proteins | Molecular modelling | Computer applications | L-Tryptophan | Mutation | Cytochromes P450
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13. Full Text Copper is an endogenous modulator of neural circuit spontaneous activity
by Sheel C. Dodani and Alana Firl and Jefferson Chan and Christine I. Nam and Allegra T. Aron and Carl S. Onak and Karla M. Ramos-Torres and Jaeho Paek and Corey M. Webster and Maria B. Feller and Christopher J. Chang
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2014, Volume 111, Issue 46, pp. 16280 - 16285
For reasons that remain insufficiently understood, the brain requires among the highest levels of metals in the body for normal function. The traditional... 
Neuroscience | Calcium | Neurons | Imaging | Chelation | Fluorescence | Retina | Sensors | Copper | Neural conduction | Molecular imaging | Fluorescent sensor | Copper signaling | Neural activity | INTRACELLULAR COPPER | CELLS | HOMEOSTASIS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MECHANISMS | molecular imaging | HIPPOCAMPAL-NEURONS | fluorescent sensor | copper signaling | PRION PROTEIN | neural activity | AMYLOID-BETA | A-BETA | Fluorescent Dyes - chemical synthesis | Retina - drug effects | Copper - physiology | Retina - growth & development | Fluorescent Dyes - analysis | Cation Transport Proteins - physiology | Male | Structure-Activity Relationship | Hippocampus - drug effects | Stilbenes - pharmacology | Dose-Response Relationship, Drug | Retina - cytology | Neurons - physiology | Female | Cation Transport Proteins - deficiency | Neurons - drug effects | Action Potentials - drug effects | Fluorescent Dyes - chemistry | Mice, Inbred C57BL | Copper - pharmacology | Rats | Mice, Transgenic | Molybdenum - pharmacology | Chelating Agents - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Mice, Knockout | Animals | Calcium Signaling - drug effects | Mice | Microscopy, Fluorescence | Neural circuitry | Research | Neurological research | Health aspects | Biological Sciences | Physical Sciences
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14. Inhibition of Copper Uptake in Yeast Reveals the Copper Transporter Ctr1p As a Potential Molecular Target of Saxitoxin
by Kathleen D Cusick and Steven C Minkin Jr and Sheel C Dodani and Christopher J Chang and Steven W Wilhelm and Gary S Sayler
Environmental Science & Technology, ISSN 0013-936X, 03/2012, Volume 46, Issue 5, p. 2959
Saxitoxin is a secondary metabolite produced by several species of dinoflagellates and cyanobacteria which targets voltage-gated sodium and potassium channels... 
Proteins | Yeast | Homeostasis | Toxins | Copper | Gene expression
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15. Full Text Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy
by Sheel C. Dodani and Dylan W. Domaille and Christine I. Nam and Evan W. Miller and Lydia A. Finney and Stefan Vogt and Christopher J. Chang and Harry B. Gray
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 15, pp. 5980 - 5985
Dynamic fluxes of s-block metals like potassium, sodium, and calcium are of broad importance in cell signaling. In contrast the concept of mobile transition... 
Molecular imaging | Calcium | Neurons | Somatic cells | Imaging | Fluorescence | Sensors | Copper | Cells | Metal ions | Fluorescent sensor | Mobile metals | Transition metal signaling | CELLULAR COPPER | HOMEOSTASIS | MULTIDISCIPLINARY SCIENCES | TRAFFICKING | AMYOTROPHIC-LATERAL-SCLEROSIS | RELEASE | molecular imaging | HIPPOCAMPAL-NEURONS | fluorescent sensor | MENKES-DISEASE | mobile metals | transition metal signaling | METALS | CHEMISTRY | LIVING CELLS | Boron Compounds - chemistry | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Spectrometry, X-Ray Emission - methods | Calcium - metabolism | Humans | Cells, Cultured | Sulfides - chemistry | Rats | Sulfides - chemical synthesis | Animals | Copper - analysis | Boron Compounds - chemical synthesis | Microscopy, Fluorescence - methods | Copper - metabolism | HEK293 Cells | Neurons - metabolism | Transition metals | X-ray spectroscopy | Research | Properties | Methods | Biological Sciences | Physical Sciences
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16. Full Text Subcellular metal imaging identifies dynamic sites of Cu accumulation in Chlamydomonas
by Hong-Hermesdorf, Anne and Hong-Hermesdorf, Anne and Miethke, Marcus and Gallaher, Sean D and Kropat, Janette and Dodani, Sheel C and Chan, Jefferson and Barupala, Dulmini and Domaille, Dylan W and Shirasaki, Dyna I and Loo, Joseph A and Weber, Peter K and Pett-Ridge, Jennifer and Stemmler, Timothy L and Chang, Christopher J and Merchant, Sabeeha S and Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1034 - 1042
We identified a Cu-accumulating structure with a dynamic role in intracellular Cu homeostasis. During Zn limitation, Chlamydomonas reinhardtii hyperaccumulates... 
ACIDOCALCISOMES | CELLS | COPPER SENSOR | TRANSPORTERS | METALLOPROTEINS | PLASTOCYANIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ZINC STORAGE | REINHARDTII | ASSIMILATION | SACCHAROMYCES-CEREVISIAE | Chlamydomonas reinhardtii - ultrastructure | Zinc - metabolism | Transcriptome | Homeostasis | Molecular Imaging | Gene Expression Profiling | Transcription Factors - genetics | Polyphosphates - metabolism | Lysosomes - ultrastructure | Transcription Factors - metabolism | Plastocyanin - biosynthesis | Lysosomes - metabolism | Cations, Divalent | Chlamydomonas reinhardtii - genetics | Copper - metabolism | Isotope Labeling | Chlamydomonas reinhardtii - metabolism | Isotopes | Hydrogen-Ion Concentration | Plastocyanin - genetics | Proteins | Catalytic oxidation | Copper | Binding sites | Membrane trafficking | Bacteria | OTHER INSTRUMENTATION | 60 APPLIED LIFE SCIENCES | Metals
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17. Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy
by Dodani, Sheel C and Domaille, Dylan W and Nam, Christine I and Miller, Evan W and Finney, Lydia A and Vogt, Stefan and Chang, Christopher J
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 04/2011, Volume 108, Issue 15, pp. 5980 - 5985
Dynamic fluxes of s-block metals like potassium, sodium, and calcium are of broad importance in cell signaling. In contrast, the concept of mobile transition... 
Journal Article
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18. Calcium-dependent copper redistributions in neuronal cells revealed by a fluorescent copper sensor and X-ray fluorescence microscopy
by Sheel C Dodani and Dylan W Domaille and Christine I Nam and Evan W Miller and Lydia A Finney and Stefan Vogt and Christopher J Chang
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 04/2011, Volume 108, Issue 15, p. 5980
Dynamic fluxes of s-block metals like potassium, sodium, and calcium are of broad importance in cell signaling. In contrast, the concept of mobile transition... 
Molecules | Signal transduction | X rays | Calcium | Microscopy | Neurons | Fluorescence | Copper | Potassium | Cells
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19. Full Text Non‐natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins
by Heel, Thomas and McIntosh, John A and Dodani, Sheel C and Meyerowitz, Joseph T and Arnold, Frances H
ChemBioChem, ISSN 1439-4227, 11/2014, Volume 15, Issue 17, pp. 2556 - 2562
Recent work has shown that engineered variants of cytochrome P450BM3 (CYP102A1) efficiently catalyze non‐natural reactions, including carbene and nitrene... 
enzyme catalysis | cyclopropanation | metalloenzyme | cytochromes | Cyclopropanation | Cytochromes | Enzyme catalysis | Metalloenzyme | CARBENE TRANSFER | HUMAN-SERUM-ALBUMIN | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-H AMINATION | Biocatalysis | Methane - analogs & derivatives | Humans | Cyclopropanes - metabolism | Cytochrome P-450 Enzyme System - metabolism | Substrate Specificity | Muramidase - metabolism | Cyclopropanes - chemistry | Hemin - metabolism | Alkenes - chemistry | Animals | Styrene - chemistry | Cattle | Hemin - chemistry | Methane - chemistry | Serum Albumin - chemistry | Serum Albumin - metabolism | Cysteine | Analysis | Olefins | Cytochrome P-450 | Heme | Cyclopropane compounds | Electronic design automation | Catalysis | Cytochrome | Enzymes | cytochrome P450
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20. Full Text Discovery of a regioselectivity switch in nitrating P450s guided by MD simulations and Markov models
by Dodani, Sheel C and Kiss, Gert and Cahn, Jackson K. B and Su, Ye and Pande, Vijay S and Arnold, Frances H
Nature chemistry, ISSN 1755-4330, 5/2016, Volume 8, Issue 5, pp. 419 - 425
The dynamic motions of protein structural elements, particularly flexible loops, are intimately linked with diverse aspects of enzyme catalysis. Engineering of... 
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