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Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 5765 - 1
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. 
Journal Article
by Dickinson, Mary E and Flenniken, Ann M and Ji, Xiao and Teboul, Lydia and Wong, Michael D and White, Jacqueline K and Meehan, Terrence F and Weninger, Wolfgang J and Westerberg, Henrik and Adissu, Hibret and Baker, Candice N and Bower, Lynette and Brown, James M and Brianna Caddle, L and Chiani, Francesco and Clary, Dave and Cleak, James and Daly, Mark J and Denegre, James M and Doe, Brendan and Dolan, Mary E and Edie, Sarah M and Fuchs, Helmut and Gailus-Durner, Valerie and Galli, Antonella and Gambadoro, Alessia and Gallegos, Juan and Guo, Shiying and Horner, Neil R and Hsu, Chih-wei and Johnson, Sara J and Kalaga, Sowmya and Keith, Lance C and Lanoue, Louise and Lawson, Thomas N and Lek, Monkol and Mark, Manuel and Marschall, Susan and Mason, Jeremy and McElwee, Melissa L and Newbigging, Susan and Nutter, Lauryl M.J and Peterson, Kevin A and Ramirez-Solis, Ramiro and Rowland, Douglas J and Ryder, Edward and Samocha, Kaitlin E and Seavitt, John R and Selloum, Mohammed and Szoke-Kovacs, Zsombor and Tamura, Masaru and Trainor, Amanda G and Tudose, Ilinca and Wakana, Shigeharu and Warren, Jonathan and Wendling, Olivia and West, David B and Wong, Leeyean and Yoshiki, Atsushi and MacArthur, Daniel G and Tocchini-Valentini, Glauco P and Gao, Xiang and Flicek, Paul and Bradley, Allan and Skarnes, William C and Justice, Monica J and Parkinson, Helen E and Moore, Mark and Wells, Sara and Braun, Robert E and Svenson, Karen L and Hrabe de Angelis, Martin and Herault, Yann and Mohun, Tim and Mallon, Ann-Marie and Mark Henkelman, R and Brown, Steve D.M and Adams, David J and Kent Lloyd, K.C and McKerlie, Colin and Beaudet, Arthur L and Bucan, Maja and Murray, Stephen A and McKay, Matthew and Urban, Barbara and Lund, Caroline and Froeter, Erin and LaCasse, Taylor and Mehalow, Adrienne and Gordon, Emily and Donahue, Leah Rae and Taft, Robert and Kutney, Peter and Dion, Stephanie and Goodwin, Leslie and Kales, Susan and Urban, Rachel and Palmer, Kristina and Pertuy, Fabien and Bitz, Deborah and ... and Int Mouse Phenotyping Consortium and The International Mouse Phenotyping Consortium
Nature, ISSN 0028-0836, 09/2016, Volume 537, Issue 7621, pp. 508 - 514
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous... 
MICRO-CT | MULTIDISCIPLINARY SCIENCES | DISEASE | GENOME-WIDE | MAMMALIAN GENE-FUNCTION | SCREENS | GLYCOGENIN-1 DEFICIENCY | IDENTIFICATION | EXPRESSION | MOUSE EMBRYO | RESOURCE | Genetic research | Phenotype | Research | High-throughput screening (Biochemical assaying) | Methods | Genotype & phenotype | Disease | Developmental biology | Genes | Genomes | Mutation | Embryos | knockout | embryonic lethal | mouse | KOMP | IMPC | EUCOMM
Journal Article
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12867 - 8
Modelling human diseases caused by large genomic rearrangements has become more accessible since the utilization of CRISPR/Cas9 in mammalian systems. In a... 
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2016, Volume 17, Issue 9, pp. 1046 - 1056
Journal Article
by De Angelis, Martin Hrabě and Nicholson, George and Selloum, Mohammed and White, Jacqueline K and Morgan, Hugh and Ramirez-Solis, Ramiro and Sorg, Tania and Wells, Sara and Fuchs, Helmut and Fray, Martin and Adams, David J and Adams, Niels C and Adler, Thure and Aguilar-Pimentel, Antonio and Ali-Hadji, Dalila and Amann, Gregory and André, Philippe and Atkins, Sarah and Auburtin, Aurelie and Ayadi, Abdel and Becker, Julien and Becker, Lore and Bedu, Elodie and Bekeredjian, Raffi and Birling, Marie-Christine and Blake, Andrew and Bottomley, Joanna and Bowl, Michael R and Brault, Véronique and Busch, Dirk H and Bussell, James N and Calzada-Wack, Julia and Cater, Heather and Champy, Marie-France and Charles, Philippe and Chevalier, Claire and Chiani, Francesco and Codner, Gemma F and Combe, Roy and Cox, Roger and Dalloneau, Emilie and Dierich, André and Di Fenza, Armida and Doe, Brendan and Duchon, Arnaud and Eickelberg, Oliver and Esapa, Chris T and Fertak, Lahcen El and Feigel, Tanja and Emelyanova, Irina and Estabel, Jeanne and Favor, Jack and Flenniken, Ann and Gambadoro, Alessia and Garrett, Lilian and Gates, Hilary and Gerdin, Anna-Karin and Gkoutos, George and Greenaway, Simon and Glasl, Lisa and Goetz, Patrice and Da Cruz, Isabelle Goncalves and Götz, Alexander and Graw, Jochen and Guimond, Alain and Hans, Wolfgang and Hicks, Geoff and Hölter, Sabine M and Höfler, Heinz and Hancock, John M and Hoehndorf, Robert and Hough, Tertius and Houghton, Richard and Hurt, Anja and Ivandic, Boris and Jacobs, Hughes and Jacquot, Sylvie and Jones, Nora and Karp, Natasha A and Katus, Hugo A and Kitchen, Sharon and Klein-Rodewald, Tanja and Klingenspor, Martin and Klopstock, Thomas and Lalanne, Valerie and Leblanc, Sophie and Lengger, Christoph and Le Marchand, Elise and Ludwig, Tonia and Lux, Aline and McKerlie, Colin and Maier, Holger and Mandel, Jean-Louis and Marschall, Susan and Mark, Manuel and Melvin, David G and Meziane, Hamid and Micklich, Kateryna and Mittelhauser, Christophe and Monassier, Laurent and ... and EUMODIC Consortium
Nature Genetics, ISSN 1061-4036, 08/2015, Volume 47, Issue 9, pp. 969 - 978
The function of the majority of genes in the mouse and human genomes remains unknown. The mouse embryonic stem cell knockout resource provides a basis for the... 
EUROPHENOME | ANNOTATION | GENETICS & HEREDITY | GENOME-WIDE | EMPRESS | KNOCKOUT MICE | ACCESS | RESOURCE | Homozygote | Phenotype | Animals | Genetic Association Studies | Humans | Mice, Inbred C57BL | Molecular Sequence Annotation | Female | Heterozygote | Male | Mutation | Mice, Knockout | Research | Gene mutations | Human genome | Identification and classification | Health aspects | Consortia | Genotype & phenotype | Physiology | Genomes | Metabolism | Power
Journal Article
by Bradley, Allan and Anastassiadis, Konstantinos and Ayadi, Abdelkader and Battey, James and Bell, Cindy and Birling, Marie-Christine and Bottomley, Joanna and Brown, Steve and Bürger, Friederike and Bult, Carol and Bushell, Wendy and Collins, Francis and Desaintes, Christian and Doe, Brendan and Aris, Economides and Eppig, Janan and Finnell, Richard and Fletcher, Colin and Fray, Martin and Frendewey, David and Friedel, Roland and Grosveld, Frank and Hansen, J and Hérault, Yann and Hicks, Geoffrey and Hörlein, Aneas and Houghton, Catherine and Hrabé De Angelis, Martin and Huylebroeck, Danny and Iyer, Vivek and Jong, Pieter and Kadin, James and Kaloff, Cornelia and Kennedy, Karen and Koutsourakis, Manousos and Kent Lloyd, K and Marschall, Susan and Mason, Jeremy and McKerlie, Colin and McLeod, Michael and Melchner, Harald and Moore, Matt and Mujica, Alejano and Nagy, Anas and Nefedov, Mikhail and Nutter, Lauryl and Pavlovic, Guillaume and Peterson, Jane and Pollock, I and Ramirez-Solis, Ramiro and Rancourt, Derrick and Raspa, Marcello and Remacle, Jacques and Ringwald, Martin and Rosen, Barry and Rosenthal, Nadia and Rossant, Janet and Ruiz Noppinger, Patricia and Ryder, S and Schick, Joel Zupicich and Schnütgen, Frank and Schofield, Christopher and Seisenberger, Claudia and Selloum, Mohammed and Simpson, Elizabeth and Skarnes, William and Smedley, Damian and Stanford, William and Francis Stewart, A and Stone, Kevin and Swan, Kate and Tadepally, Hamsa and Teboul, Jean Louis and Tocchini-Valentini, Glauco and Valenzuela, David and West, Anthony and Yamamura, Ken-Ichi and Yoshinaga, Yuko and Wurst, Martin
Mammalian Genome, ISSN 0938-8990, 10/2012, Volume 23, Issue 9-10, pp. 580 - 586
textabstractIn 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene... 
Life Sciences | Anatomy | Zoology | Cell Biology | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | EMBRYONIC STEM-CELLS | GENETICS & HEREDITY | Mice, Knockout - genetics | Mice | Animals | Internet | Internationality
Journal Article
NATURE PROTOCOLS, ISSN 1754-2189, 07/2019, Volume 14, Issue 7, pp. 1991 - 2014
Ploidy represents the number of chromosome sets in a cell. Although gametes have a haploid genome (n), most mammalian cells have diploid genomes (2n). The... 
GENERATION | GENETICS | CANCER | DISCOVERY | BIOCHEMICAL RESEARCH METHODS | Gametes | Ploidy | Genes | Embryo cells | Stem cell transplantation | Derivation | Genomes | Embryos | Genetic screening | Mammalian cells | Mutagenesis | Stem cells | Cell lines | Mutation | Chromosomes
Journal Article
Journal Article
by Balmus, Gabriel and Larrieu, Delphine and Barros, Ana C and Collins, Casey and Abrudan, Monica and Demir, Mukerrem and Geisler, Nicola J and Lelliott, Christopher J and White, Jacqueline K and Karp, Natasha A and Atkinson, James and Kirton, Andrea and Jacobsen, Matt and Clift, Dean and Rodriguez, Raphael and Shannon, Carl and Sanderson, Mark and Gates, Amy and Dench, Joshua and Vancollie, Valerie and McCarthy, Catherine and Pearson, Selina and Cambridge, Emma and Isherwood, Christopher and Wilson, Heather and Grau, Evelyn and Galli, Antonella and Hooks, Yvette E and Tudor, Catherine L and Green, Angela L and Kussy, Fiona L and Tuck, Elizabeth J and Siragher, Emma J and McLaren, Robbie S. B and Swiatkowska, Agnieszka and Caetano, Susana S and Mazzeo, Cecilia Icoresi and Dabrowska, Monika H and Maguire, Simon A and Lafont, David T and Anthony, Lauren F. E and Sumowski, Maksymilian T and Bussell, James and Sinclair, Caroline and Brown, Ellen and Doe, Brendan and Wardle-Jones, Hannah and Griggs, Nicola and Woods, Mike and Kundi, Helen and McConnell, George and Doran, Joanne and Griffiths, Mark N. D and Kipp, Christian and Holroyd, Simon A and Gannon, David J and Alcantara, Rafael and Ramirez-Solis, Ramiro and Bottomley, Joanna and Ingle, Catherine and Ross, Victoria and Barrett, Daniel and Sethi, Debarati and Gleeson, Diane and Burvill, Jonathan and Platte, Radka and Ryder, Edward and Sins, Elodie and Miklejewska, Evelina and Von Schiller, Dominique and Duddy, Graham and Urbanova, Jana and Boroviak, Katharina and Imran, Maria and Reddy, Shalini Kamu and Adams, David J and Jackson, Stephen P and Sanger Mouse Genetics Project
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1700 - 14
Journal Article