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Nature Reviews Genetics, ISSN 1471-0056, 02/2018, Volume 19, Issue 2, pp. 67 - 80
Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art instrumentation or the need for years of hands-on experience,... 
DRUG | OFF-TARGET | DNA | GENETICS & HEREDITY | RNAI SCREENS | LARGE-SCALE | SGRNA DESIGN | CAS9 | IDENTIFICATION | GENOME | REVEALS | Genes | Genomics | Genetic screening | CRISPR | New technology
Journal Article
The FEBS Journal, ISSN 1742-464X, 09/2016, Volume 283, Issue 17, pp. 3160 - 3161
This Special Issue on CRISPR comprises a series of nine reviews that cover the development and application of this technology to an array of biological... 
Gene Editing - methods | Models, Genetic | Animals | Humans | CRISPR-Cas Systems
Journal Article
Journal Article
Nature Biotechnology, ISSN 1087-0156, 12/2014, Volume 32, Issue 12, pp. 1262 - 1267
Journal Article
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
MELANOMA | T-CELL IMMUNITY | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein
Journal Article