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PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e86815
The reduction of functional beta cell mass is a key feature of type 2 diabetes. Here, we studied metabolic functions and islet gene expression profiles of... 
OXYGEN-REGULATED PROTEIN | HIGH-FAT DIET | MULTIDISCIPLINARY SCIENCES | MOUSE | ANIMAL-MODELS | RESISTANCE | INSULIN-RELEASE | EXTRACELLULAR-MATRIX | BETA-CELL MASS | SECRETION | FAILURE | Mitochondrial Proteins - genetics | Insulin - blood | NADP Transhydrogenase, AB-Specific - genetics | Obesity - genetics | Hypoxia-Inducible Factor 1 - genetics | Insulin-Secreting Cells - metabolism | Gene Deletion | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Hyperinsulinism - genetics | Hypoxia-Inducible Factor 1 - biosynthesis | Hyperinsulinism - metabolism | Dietary Fats - adverse effects | Obesity - chemically induced | Up-Regulation - genetics | Transcription Factors - genetics | Obesity - metabolism | Obesity - pathology | Transcription Factors - metabolism | Up-Regulation - drug effects | Hyperinsulinism - pathology | Hyperinsulinism - chemically induced | Animals | Oxygen Consumption - drug effects | Oxygen Consumption - genetics | Mice | Insulin-Secreting Cells - pathology | Oxidative Stress - drug effects | Type 2 diabetes | Niacinamide | Obesity | Blood sugar | Genes | Gene expression | Insulin | DNA microarrays | Diet | Analysis | Genetic research | Insulin resistance | NADPH | Oxidative stress | Cyanide | Hyperinsulinemia | Cyanides | Glucose | Gene deletion | Kinases | High fat diet | Pathways | Clonal deletion | Rodents | Deletion | Extracellular matrix | Pancreas | Carbonyls | Oxygen | Secretion | Diabetes mellitus | Oxygen consumption | Metabolism | Hypoxia | Metabolic pathways | Nicotinamide | Mutation | Islets of Langerhans
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 09/2017, Volume 125, Issue 9, p. 097022
BACKGROUND: Exposure to the environmental endocrine disruptor bisphenol A (BPA) is ubiquitous and associated with the increased risk of diabetes and obesity.... 
INSULIN-SECRETION | GROWTH-FACTOR-II | ENVIRONMENTAL SCIENCES | GLUCOSE-HOMEOSTASIS | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | MESSENGER-RIBONUCLEIC-ACID | PERINATAL EXPOSURE | ESTROGEN-RECEPTOR-ALPHA | EPIGENETIC DISRUPTION | MITOCHONDRIAL DYSFUNCTION | TOXICOLOGY | BETA-CELL MASS | DEVELOPMENTAL EXPOSURE | Environmental Pollutants - adverse effects | Islets of Langerhans - drug effects | Epigenesis, Genetic | Mice, Inbred C57BL | Prenatal Exposure Delayed Effects - physiopathology | Dose-Response Relationship, Drug | Pregnancy | Endocrine Disruptors - adverse effects | Insulin - metabolism | Animals | Benzhydryl Compounds - adverse effects | Phenols - adverse effects | Sex Factors | Maternal Exposure - adverse effects | Female | Mice | Insulin Secretion | Prenatal Exposure Delayed Effects - chemically induced | Bisphenol-A | Maternal-fetal exchange | Health aspects | Perinatal exposure | Body fat | Sex | Males | Mitochondria | Metabolites | Rodents | DNA methylation | Oxidation | Insulin-like growth factor II | Pancreas | Deoxyribonucleic acid--DNA | Secretion | Diabetes mellitus | Health risks | Sex differences | Exposure | Metabolism | Gene expression | Insulin | Embryos | Molecular chains | Studies | Glucose tolerance | Bisphenol A | Progeny | Offspring | Molecular modelling | Cell death | Phenols | Islets of Langerhans | Diabetes | Methylation | Females | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 09/2019, Volume 116, Issue 37, pp. 18684 - 18690
Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has... 
Epidemics | Acetylcholine receptors (muscarinic) | Secretion | Diabetes mellitus | Homeostasis | Glucose | Insulin | Beta cells | Glucose tolerance | Side effects | Receptors | Allosteric properties | Mice | Pancreas | Diabetes mellitus (non-insulin dependent)
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 01/2012, Volume 302, Issue 1, pp. 87 - 102
Journal Article
Journal Article
Journal Article
Journal Article
Molecular Metabolism, ISSN 2212-8778, 08/2019, Volume 26, pp. 45 - 56
Pancreatic β cell failure plays a central role in the development of type 2 diabetes (T2D). While the transcription factors shaping the β cell gene expression... 
Signaling | β cell | Translational regulation | RNA-Binding proteins | Stress | beta cell | APOPTOSIS | RNA HELICASE | PHOSPHORYLATION | TRANSLATION | NUCLEAR RIBONUCLEOPROTEIN-K | HNRNP-K | DNA | ENDOCRINOLOGY & METABOLISM | BINDING | VECTORS
Journal Article