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ChemMedChem, ISSN 1860-7179, 08/2014, Volume 9, Issue 8, pp. 1638 - 1654
N-Substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines are a class of pure opioid receptor antagonists with a novel pharmacophore. This opioid... 
Journal Article
Methods in molecular biology (Clifton, N.J.), 2011, Volume 685, pp. 3 - 25
High-throughput chemistry (HTC) is approaching its 20-year anniversary. Since 1992, some 5,000 chemical libraries, prepared for the purpose of biological... 
Small Molecule Libraries - chemistry | Small Molecule Libraries - history | Small Molecule Libraries - pharmacology | Drug Discovery - history | History, 21st Century | History, 20th Century | Humans | Small Molecule Libraries - chemical synthesis | Drug Discovery - methods | Drug Evaluation, Preclinical
Journal Article
Synlett, ISSN 0936-5214, 10/2009, Volume 2009, Issue 17, pp. 2857 - 2861
Abstract Parallel synthesis of α-substituted pyrrolidines, piper­idines, morpholines, piperazines and diazaspirocycles was achieved in a single reaction step... 
letter | annulation | HETEROCYCLES | NITROGEN | CHEMISTRY, ORGANIC | intramolecular | heterocycle | amine | parallel synthesis | Amine | Parallel synthesis | Heterocycle | Annulation | Intramolecular
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 10/2019, Volume 10
Refractory anaphylaxis (unresponsive to treatment with at least two doses of minimum 300 μg adrenaline) is a rare and often fatal hypersensitivity reaction.... 
Practice | Anaphylaxis | Diagnosis | Physicians | Risk factors | Methylene blue | beta-blockers | adrenaline (epinephrine) | insect venom allergy | anaphylaxis | vasoconstriction | drug allergic reactions
Journal Article
Current Pharmaceutical Design, ISSN 1381-6128, 10/2009, Volume 15, Issue 29, pp. 3345 - 3366
Non-selective cannabinoid ligands display a wide range of physiological effects including analgesic, anti-inflammatory, anti-convulsive and immuno-suppressive... 
NEUROPATHIC PAIN | SERIES | RECEPTOR AGONISTS | IN-VIVO | ENDOCANNABINOID SYSTEM | N-ARYLAMIDE OXADIAZOLES | PHARMACOLOGY & PHARMACY | ANALGESIC ACTIVITY | DERIVATIVES | 2-ARYLIMINO-5,6-DIHYDRO-4H-1,3-THIAZINES | DISCOVERY
Journal Article
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 10/2009, Volume 19, Issue 20, pp. 5931 - 5935
Replacement of the phenyl ring in our previous (morpholinomethyl)aniline carboxamide cannabinoid receptor ligands with a pyridine ring led to the discovery of... 
Journal Article
ChemMedChem, ISSN 1860-7179, 11/2007, Volume 2, Issue 11, pp. 1552 - 1570
For thousands of years mu opioid agonists such as morphine have been utilized for their analgesic properties. Today, morphine and related compounds are still... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 07/2004, Volume 69, Issue 15, pp. 5147 - 5149
10-Hydroxy-10,9-boroxarophenanthrenes were obtained as unexpected major products upon BBr3-mediated O-demethylation of 2-methoxybiaryls. The formation likely... 
CHEMISTRY, ORGANIC | DERIVATIVES | ACID | Chemical reactions | Synthesis | Analysis | Organic compounds
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 20, pp. 5931 - 5935
A novel series of pyridine derivatives was synthesized and identified as potent and selective CB agonists. Replacement of the phenyl ring in our previous... 
Selective CB 2 agonists | Pain | Cannabinoid receptors | Pyridine derivatives
Journal Article
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2009, Volume 52, Issue 18, pp. 5685 - 5702
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2008, Volume 51, Issue 19, pp. 5893 - 5896
Journal Article
Journal of chromatography. A, 11/2009, Volume 1216, Issue 45, p. 7708
Chiral recognition and resolution of methanobenzazocines was investigated by HPLC using polysaccharide, Pirkle-type, native and derivatized beta-cyclodextrin... 
Chromatography, High Pressure Liquid - methods | Stereoisomerism | Benzomorphans - chemistry
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2015, Volume 6, Issue 10, pp. 1080 - 1085
Antibacterials with a novel mechanism of action offer a great opportunity to combat widespread antimicrobial resistance. Bacterial DNA Gyrase is a clinically... 
GyrB | topoisomerase | Antibacterial | indazole | MRSA
Journal Article
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