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science & technology (15) 15
life sciences & biomedicine (10) 10
humans (8) 8
animals (7) 7
immunology (5) 5
mice (5) 5
multidisciplinary sciences (5) 5
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cell biology (4) 4
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research (4) 4
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cytidine deaminase - metabolism (3) 3
genetic aspects (3) 3
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nucleic acids (3) 3
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4,4'-diisothiocyanostilbene-2,2'-disulfonic acid - pharmacology (2) 2
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immunoglobulin class switching (2) 2
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methods (2) 2
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ribonucleic acid--rna (2) 2
sciadv r-articles (2) 2
scientific community (2) 2
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sensors (2) 2
vector-borne diseases (2) 2
zika virus - genetics (2) 2
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5'-nucleotidase - immunology (1) 1
ablation (1) 1
activation-induced cytidine deaminase (1) 1
active transport, cell nucleus - drug effects (1) 1
active transport, cell nucleus - radiation effects (1) 1
agricultural and biological sciences (1) 1
amplification (1) 1
analysis (1) 1
antibacterial agents (1) 1
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antibiotic tolerance (1) 1
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antibodies (1) 1
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1. Full Text Nucleic acid detection with CRISPR-Cas13a/C2c2
by Gootenberg, Jonathan S and Abudayyeh, Omar O and Lee, Jeong Wook and Essletzbichler, Patrick and Dy, Aaron J and Joung, Julia and Verdine, Vanessa and Donghia, Nina and Daringer, Nichole M and Freije, Catherine A and Myhrvold, Cameron and Bhattacharyya, Roby P and Livny, Jonathan and Regev, Aviv and Koonin, Eugene V and Hung, Deborah T and Sabeti, Pardis C and Collins, James J and Zhang, Feng
Science (American Association for the Advancement of Science), ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. 438 - 442
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Circulating Tumor DNA - analysis | Zika Virus - genetics | Circulating Tumor DNA - genetics | Ribonucleases - chemistry | Humans | Bacterial Proteins - chemistry | RNA, Viral - analysis | RNA Cleavage | Zika Virus - isolation & purification | Dengue Virus - genetics | Bacteria - isolation & purification | RNA, Viral - genetics | Zika Virus Infection - diagnosis | Neoplasms - genetics | Point-of-Care Systems | Clustered Regularly Interspaced Short Palindromic Repeats | DNA, Bacterial - analysis | Bacteria - pathogenicity | Dengue Virus - isolation & purification | Mutation | Dengue - diagnosis | Methods | Nucleotide sequencing | DNA sequencing | Vector-borne diseases | Pathogens | CRISPR | Target recognition | Nucleotide sequence | Dengue | Viruses | Zika virus | Nucleic acids | Ribonuclease | Recombinase | Ribonucleic acid--RNA | Sensitivity | Genotyping | Reagents | Bacteria | Deoxyribonucleic acid--DNA | Index Medicus | Amplification | Ribonucleic acids | Deoxyribonucleic acid
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2. Full Text A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers
by Takahashi, Melissa K and Tan, Xiao and Dy, Aaron J and Braff, Dana and Akana, Reid T and Furuta, Yoshikazu and Donghia, Nina and Ananthakrishnan, Ashwin and Collins, James J
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3347 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Inflammation - pathology | Species Specificity | Humans | RNA, Messenger - genetics | Biomarkers - analysis | Clostridium difficile - genetics | Computational Biology | Gastrointestinal Microbiome | Clostridium difficile - isolation & purification | RNA, Messenger - metabolism | Feces - microbiology | Synthetic Biology - methods | RNA, Ribosomal, 16S - genetics | Paper | Synthetic Biology - economics | Demand analysis | Microbiomes | mRNA | Biology | Ribonucleic acid--RNA | Microbiota | Correlation analysis | Biomarkers | Longitudinal studies | Synthetic biology | Sensors | Intestinal microflora | Cost analysis | Index Medicus
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3. Full Text Rapid, Low-Cost Detection of Zika Virus Using Programmable Biomolecular Components
by Pardee, Keith and Green, Alexander A and Takahashi, Melissa K and Braff, Dana and Lambert, Guillaume and Lee, Jeong Wook and Ferrante, Tom and Ma, Duo and Donghia, Nina and Fan, Melina and Daringer, Nichole M and Bosch, Irene and Dudley, Dawn M and O’Connor, David H and Gehrke, Lee and Collins, James J
Cell (Cambridge), ISSN 0092-8674, 05/2016, Volume 165, Issue 5, pp. 1255 - 1266
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Zika Virus - classification | Molecular Diagnostic Techniques - methods | Zika Virus - genetics | Macaca mulatta | Dengue - virology | Molecular Diagnostic Techniques - economics | Zika Virus - isolation & purification | Genetic Techniques | Zika Virus Infection - virology | Animals | Zika Virus Infection - diagnosis | Blood - virology | Computer Simulation | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Viral - isolation & purification | Dengue - diagnosis | Usage | Sensors | RNA | Dengue viruses | Genomics | Biomedical engineering | Index Medicus
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4. Full Text Portable, On-Demand Biomolecular Manufacturing
by Pardee, Keith and Slomovic, Shimyn and Nguyen, Peter Q and Lee, Jeong Wook and Donghia, Nina and Burrill, Devin and Ferrante, Tom and McSorley, Fern R and Furuta, Yoshikazu and Vernet, Andyna and Lewandowski, Michael and Boddy, Christopher N and Joshi, Neel S and Collins, James J
Cell (Cambridge), ISSN 0092-8674, 09/2016, Volume 167, Issue 1, pp. 248 - 259.e12
cell-free expression | on-demand biosynthesis | synthetic biology | vaccine antigens | portable molecular manufacturing | antibody mimetic conjugates | freeze-dried | decentralized biomanufacturing | antimicrobial peptides | violacein biosynthetic pathway | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Biosynthesis | Synthetic Biology | Vaccines - genetics | Animals | Combinatorial Chemistry Techniques | Cell-Free System | Vaccines - biosynthesis | Humans | Antimicrobial Cationic Peptides - biosynthesis | Antibody Formation | Transcription, Genetic | Antimicrobial Cationic Peptides - genetics | Proteins | Viral antibodies | Therapeutics | Developing countries | Antibodies | Homeopathy | Materia medica and therapeutics | Biomedical engineering | Antigens | Peptides | Freedom of speech | Index Medicus
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5. Full Text A Deep Learning Approach to Antibiotic Discovery
by Stokes, Jonathan M and Yang, Kevin and Swanson, Kyle and Jin, Wengong and Cubillos-Ruiz, Andres and Donghia, Nina M and MacNair, Craig R and French, Shawn and Carfrae, Lindsey A and Bloom-Ackermann, Zohar and Tran, Victoria M and Chiappino-Pepe, Anush and Badran, Ahmed H and Andrews, Ian W and Chory, Emma J and Church, George M and Brown, Eric D and Jaakkola, Tommi S and Barzilay, Regina and Collins, James J
Cell (Cambridge), ISSN 0092-8674, 02/2020, Volume 180, Issue 4, pp. 688 - 702.e13
antibiotic tolerance | drug discovery | machine learning | antibiotic resistance | antibiotics | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Computer science | Drug resistance in microorganisms | Neural networks | Analysis | Machine learning | Drug discovery | Phylogeny | Artificial intelligence | Antibacterial agents | Biomedical engineering | Index Medicus
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6. Full Text Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination
by Donghia, Nina M and Coffey, Eliot and He, Yishu and Wilpan, Robert Y and Ames, Jacquelyn and Mills, Kevin D and Maynard, Jane and King, Benjamin L and Hasham, Muneer G and Snow, Kathy J
Nature immunology, ISSN 1529-2908, 09/2010, Volume 11, Issue 9, pp. 820 - 826
Life Sciences & Biomedicine | Immunology | Science & Technology | Genomic Instability | DNA-Binding Proteins - immunology | Cell Survival | Humans | Cells, Cultured | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | B-Lymphocytes - immunology | Flow Cytometry | Cell Cycle | Cytidine Deaminase - metabolism | DNA Breaks | Recombination, Genetic - genetics | Physiological aspects | Immunoglobulins | Genetic aspects | Research | B cells | Genetic recombination | Index Medicus
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7. Full Text A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination
by Vuong, Bao Q and Herrick-Reynolds, Kayleigh and Vaidyanathan, Bharat and Pucella, Joseph N and Ucher, Anna J and Donghia, Nina M and Gu, Xiwen and Nicolas, Laura and Nowak, Urszula and Rahman, Numa and Strout, Matthew P and Mills, Kevin D and Stavnezer, Janet and Chaudhuri, Jayanta
Nature immunology, ISSN 1529-2908, 2013, Volume 14, Issue 11, pp. 1183 - 1189
Life Sciences & Biomedicine | Immunology | Science & Technology | DNA-(Apurinic or Apyrimidinic Site) Lyase - immunology | B-Lymphocytes - cytology | Cytidine Deaminase - immunology | Phosphorylation | Signal Transduction | Cytidine Deaminase - genetics | Gene Expression Regulation | Serine - immunology | DNA Breaks, Double-Stranded | Serine - metabolism | Ataxia Telangiectasia Mutated Proteins - immunology | DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics | Feedback, Physiological | Animals | B-Lymphocytes - immunology | Protein Binding | Mice | Ataxia Telangiectasia Mutated Proteins - genetics | Immunoglobulin Class Switching | Immunoglobulin Heavy Chains - immunology | Immunoglobulin Heavy Chains - genetics | Physiological aspects | Immunoglobulins | Research | Health aspects | DNA damage | Index Medicus
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8. Full Text Genetic and small molecule disruption of the AID/RAD51 axis similarly protects nonobese diabetic mice from type 1 diabetes through expansion of regulatory B lymphocytes
by Ratiu, Jeremy J and Racine, Jeremy J and Hasham, Muneer G and Wang, Qiming and Branca, Jane A and Chapman, Harold D and Zhu, Jing and Donghia, Nina and Philip, Vivek and Schott, William H and Wasserfall, Clive and Atkinson, Mark A and Mills, Kevin D and Leeth, Caroline M and Serreze, David V
The Journal of immunology (1950), ISSN 0022-1767, 06/2017, Volume 198, Issue 11, pp. 4255 - 4267
Life Sciences & Biomedicine | Immunology | Science & Technology | Cytidine Deaminase - antagonists & inhibitors | Somatic Hypermutation, Immunoglobulin | Diabetes Mellitus, Type 1 - prevention & control | 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid - pharmacology | Lymphocyte Activation | Cytidine Deaminase - genetics | Carrier Proteins - antagonists & inhibitors | Nuclear Proteins - metabolism | B-Lymphocytes, Regulatory - immunology | Carrier Proteins - genetics | Autoantibodies - immunology | Animals | Carrier Proteins - metabolism | Cytidine Deaminase - metabolism | Diabetes Mellitus, Experimental | Nuclear Proteins - antagonists & inhibitors | Nuclear Proteins - deficiency | 5'-Nucleotidase - immunology | CRISPR-Cas Systems | Mice, Inbred NOD | Mice | Diabetes Mellitus, Type 1 - immunology | Nuclear Proteins - genetics | Immunoglobulin Class Switching | CRISPR | Autoantibodies | Diabetes mellitus | DNA damage | Homologous recombination | Immunoglobulin G | Activation-induced cytidine deaminase | Homology | Genomes | Lymphocytes T | Pharmacology | Ablation | Class switching | Somatic hypermutation | Lymphocytes B | Lymphocytes | Antigen-presenting cells | Rodents | CD73 antigen | Diabetes | Genetic modification | Deoxyribonucleic acid--DNA | Cytidine deaminase | Index Medicus | Abridged Index Medicus
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9. Full Text ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells
by Maas, Sarah A and Donghia, Nina M and Tompkins, Kathleen and Foreman, Oded and Mills, Kevin D
BMC biology, ISSN 1741-7007, 10/2010, Volume 8, Issue 1, pp. 132 - 132
Biology | Life Sciences & Biomedicine - Other Topics | Life Sciences & Biomedicine | Science & Technology | Cell Proliferation | Humans | Multipotent Stem Cells - metabolism | Genomic Instability - physiology | Mesenchymal Stromal Cells - metabolism | Nuclear Proteins - metabolism | Gene Expression Profiling | Signal Transduction - genetics | DNA Repair - genetics | Mesenchymal Stromal Cells - cytology | Animals | Multipotent Stem Cells - cytology | Genes, Tumor Suppressor - physiology | Endonucleases | Signal Transduction - physiology | Mice | Sarcoma - genetics | Nuclear Proteins - genetics | Genomic Instability - genetics | Cell proliferation | Physiological aspects | Genetic aspects | Research | Genes | Stem cells | Studies | Proteins | Kinases | DNA repair | Index Medicus
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