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Acta Neuropathologica, ISSN 0001-6322, 07/2010, Volume 120, Issue 1, pp. 33 - 41
Journal Article
Clinical cancer research, ISSN 1078-0432, 2011, Volume 17, Issue 10, pp. 3455 - 3468
To explore the effect of dihydropyrimidine dehydrogenase (DPD) single nucleotide polymorphisms (SNP) and haplotypes on outcome of capecitabine. Germline DNA... 
IVS14+1G-GREATER-THAN-A MUTATION | 1ST-LINE TREATMENT | MULTICENTER RANDOMIZED-TRIAL | POINT MUTATION | ONCOLOGY | DIHYDROPYRIMIDINE DEHYDROGENASE-DEFICIENCY | FLUOROURACIL PLUS LEUCOVORIN | PHASE-III | SPLICE DONOR SITE | DPD DEFICIENCY | SEVERE 5-FLUOROURACIL TOXICITY | Haplotypes | Capecitabine | Colorectal Neoplasms - genetics | Humans | Middle Aged | Polymorphism, Single Nucleotide - physiology | Male | Case-Control Studies | Antimetabolites, Antineoplastic - administration & dosage | Dose-Response Relationship, Drug | Fluorouracil - therapeutic use | Clinical Trials, Phase III as Topic | Deoxycytidine - therapeutic use | Fluorouracil - administration & dosage | Fluorouracil - adverse effects | Colorectal Neoplasms - drug therapy | Drug-Related Side Effects and Adverse Reactions - genetics | Aged, 80 and over | Adult | Deoxycytidine - adverse effects | Female | Retrospective Studies | Carcinoma - drug therapy | Fluorouracil - analogs & derivatives | Deoxycytidine - administration & dosage | Treatment Outcome | Disease Progression | Randomized Controlled Trials as Topic | Antimetabolites, Antineoplastic - therapeutic use | Antimetabolites, Antineoplastic - adverse effects | Carcinoma - genetics | Aged | Biomarkers, Tumor - genetics | Biomarkers, Pharmacological - metabolism | Dihydrouracil Dehydrogenase (NADP) - metabolism | Deoxycytidine - analogs & derivatives | Dihydrouracil Dehydrogenase (NADP) - genetics | Cohort Studies | Index Medicus
Journal Article
Journal Article
Pharmacogenetics and genomics, ISSN 1744-6872, 2008, Volume 18, Issue 6, pp. 515 - 523
PURPOSE: The anticancer agent, cyclophosphamide, is metabolized by cytochrome P450 (CYP), glutathione S-transferase (GST) and aldehyde dehydrogenase (ALDH)... 
4-hydroxycyclophosphamide | Population pharmacokinetics | Cyclophosphamide | Pharmacogenetics | SYSTEMIC-LUPUS-ERYTHEMATOSUS | GENETIC POLYMORPHISMS | FUNCTIONAL-CHARACTERIZATION | PULSE CYCLOPHOSPHAMIDE | TANDEM MASS-SPECTROMETRY | TRANSFERASE A1 PROMOTER | population pharmacokinetics | BREAST-CANCER | HIGH-DOSE CYCLOPHOSPHAMIDE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | cyclophosphamide | PHARMACOLOGY & PHARMACY | HUMAN LIVER | SIMULTANEOUS QUANTIFICATION | pharmacogenetics | Cytochrome P-450 CYP2C9 | Cyclophosphamide - analogs & derivatives | Oxidoreductases, N-Demethylating - genetics | Humans | Middle Aged | Aryl Hydrocarbon Hydroxylases - genetics | Male | DNA Primers - genetics | Neoplasms, Germ Cell and Embryonal - genetics | Breast Neoplasms - metabolism | Ovarian Neoplasms - genetics | Glutathione Transferase - genetics | Cytochrome P-450 CYP3A - genetics | Base Sequence | Adult | Female | Neoplasms, Germ Cell and Embryonal - drug therapy | Ovarian Neoplasms - metabolism | Ovarian Neoplasms - drug therapy | Glutathione S-Transferase pi - genetics | Aldehyde Dehydrogenase - genetics | Neoplasms, Germ Cell and Embryonal - metabolism | Breast Neoplasms - drug therapy | Polymorphism, Genetic | Breast Neoplasms - genetics | Cytochrome P-450 CYP2C19 | Adolescent | Cytochrome P-450 Enzyme System - genetics | Cyclophosphamide - pharmacokinetics | Cytochrome P-450 CYP2B6 | Cohort Studies | Index Medicus
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 8, Issue 6, pp. 455 - 466
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2009, Volume 67, Issue 1, pp. 50 - 60
Journal Article
Cancer, ISSN 0008-543X, 05/2012, Volume 118, Issue 9, pp. 2466 - 2475
BACKGROUND: The authors assessed the impact of germline polymorphisms on clinical outcome in patients with advanced nonsmall cell lung cancer (NSCLC) who... 
gemcitabine | cisplatin | bronchial neoplasms | DNA repair | carboplatin | pharmacogenetics | Chemotherapy | Usage | Care and treatment | Pharmacogenetics | Lung cancer | Carboplatin | Dosage and administration | Research | Diagnosis | Cancer
Journal Article
MOLECULAR NEURODEGENERATION, ISSN 1750-1326, 2006, Volume 1, Issue 1, pp. 13 - 13
Amyloid beta is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene,... 
NEUROSCIENCES
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2011, Volume 17, Issue 10, pp. 3455 - 3468
PURPOSE: To explore the effect of dihydropyrimidine dehydrogenase (DPD) single nucleotide polymorphisms (SNP) and haplotypes on outcome of capecitabine.... 
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 9, Issue 1, pp. 71 - 71
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2006, Volume 12, Issue 19, pp. 5786 - 5793
PURPOSE: Despite the extensive clinical experience with docetaxel, unpredictable interindividual variability in efficacy and toxicity remain important... 
Journal Article
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