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JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2015, Volume 65, Issue 7, pp. 668 - 680
Abstract Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting... 
Cardiovascular | Internal Medicine | β-blocker | nebivolol | inflammation | endothelial dysfunction | pulmonary hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | beta-blocker | RATS | CROSS-TALK | THERAPY | SMOOTH-MUSCLE HYPERPLASIA | ARTERIAL-HYPERTENSION | ANIMAL-MODELS | BLOCKADE | PROGRESSION | Ethanolamines - pharmacology | Benzopyrans - therapeutic use | Cell Proliferation | Rats, Wistar | Metoprolol - pharmacology | Humans | Monocrotaline | Adrenergic beta-1 Receptor Antagonists - pharmacology | Hypertension, Pulmonary - physiopathology | Endothelium, Vascular - drug effects | Male | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Hypertension, Pulmonary - drug therapy | Cell Culture Techniques | Vascular Remodeling - drug effects | Benzopyrans - pharmacology | Disease Models, Animal | Nebivolol | Endothelium, Vascular - physiopathology | Rats | Metoprolol - therapeutic use | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Animals | Myocytes, Smooth Muscle | Cell Communication - drug effects | Endothelium, Vascular - pathology | Ethanolamines - therapeutic use | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Heart | Sects | Pulmonary hypertension | Endothelium | Studies | Cell growth | Pulmonary arteries | Mortality | Smooth muscle | Veins & arteries | Life Sciences
Journal Article
Journal Article
Orphanet Journal of Rare Diseases, ISSN 1750-1172, 2013, Volume 8, Issue 1, p. 97
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2012, Volume 186, Issue 8, pp. 780 - 789
Journal Article
Nature Genetics, ISSN 1061-4036, 05/2013, Volume 45, Issue 5, pp. 518 - 521
Journal Article
Journal Article
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2013, Volume 218, pp. 59 - 75
Pulmonary hypertension (PH) is a life-threatening and often fatal disease, characterized by elevated pulmonary vascular resistance and secondary right... 
Pulmonary veno-occlusive disease | Medial hypertrophy | Histology | Intimal fibrosis | Pulmonary hypertension | Plexiform lesion | Animals | Connective Tissue Diseases - pathology | Humans | Fibrosis | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Pulmonary Veno-Occlusive Disease - pathology | Hypertrophy
Conference Proceeding
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2015, Volume 192, Issue 8, pp. 983 - 997
Rationale: Inflammation and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH). CD74 is a receptor for the... 
Macrophage migration inhibitory factor | CD74 signaling pathway | Endothelial dysfunction | Adhesion molecules | Pulmonary hypertension | CD74 | RECRUITMENT | macrophage migration inhibitory factor | pulmonary hypertension | PHENOTYPE | MIF | CELL-SURVIVAL | PREVENTS | endothelial dysfunction | FIBROBLAST GROWTH FACTOR-2 | adhesion molecules | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | MICE | CONTRIBUTES | CRITICAL CARE MEDICINE | Leukocytes, Mononuclear - metabolism | Up-Regulation | Humans | Macrophage Migration-Inhibitory Factors - immunology | Middle Aged | Macrophage Migration-Inhibitory Factors - metabolism | Male | Case-Control Studies | Familial Primary Pulmonary Hypertension - metabolism | Pulmonary Artery - metabolism | Familial Primary Pulmonary Hypertension - immunology | Leukocytes, Mononuclear - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | Adult | Female | Histocompatibility Antigens Class II - metabolism | Disease Models, Animal | Endothelium, Vascular - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Signal Transduction | Endothelial Cells - metabolism | Intercellular Adhesion Molecule-1 - immunology | Cells, Cultured | Endothelium, Vascular - physiopathology | Rats | E-Selectin - metabolism | E-Selectin - immunology | Inflammation | Endothelial Cells - immunology | Intercellular Adhesion Molecule-1 - metabolism | Animals | Histocompatibility Antigens Class II - immunology | Endothelium, Vascular - metabolism | Antigens, Differentiation, B-Lymphocyte - metabolism | In Vitro Techniques | Vascular Cell Adhesion Molecule-1 - metabolism | Pulmonary Artery - immunology
Journal Article
Respiratory Research, ISSN 1465-9921, 12/2011, Volume 12, Issue 1, pp. 1 - 17
Journal Article
Circulation, ISSN 0009-7322, 2013, Volume 128, Issue 18, pp. 2016 - 2025
Journal Article