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Journal Article
Circulation, ISSN 0009-7322, 2013, Volume 128, Issue 18, pp. 2016 - 2025
Journal Article
Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 5, pp. 518 - 521
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 65, Issue 7, pp. 668 - 680
Abstract Background Endothelial cell (EC) dysfunction plays a central role in the pathogenesis of pulmonary arterial hypertension (PAH), promoting... 
Cardiovascular | Internal Medicine | β-blocker | nebivolol | inflammation | endothelial dysfunction | pulmonary hypertension | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | beta-blocker | RATS | CROSS-TALK | THERAPY | SMOOTH-MUSCLE HYPERPLASIA | ARTERIAL-HYPERTENSION | ANIMAL-MODELS | BLOCKADE | PROGRESSION | Ethanolamines - pharmacology | Benzopyrans - therapeutic use | Cell Proliferation | Rats, Wistar | Metoprolol - pharmacology | Humans | Monocrotaline | Adrenergic beta-1 Receptor Antagonists - pharmacology | Hypertension, Pulmonary - physiopathology | Endothelium, Vascular - drug effects | Male | Adrenergic beta-1 Receptor Antagonists - therapeutic use | Hypertension, Pulmonary - drug therapy | Cell Culture Techniques | Vascular Remodeling - drug effects | Benzopyrans - pharmacology | Disease Models, Animal | Nebivolol | Endothelium, Vascular - physiopathology | Rats | Metoprolol - therapeutic use | Pulmonary Artery - physiopathology | Pulmonary Artery - drug effects | Animals | Myocytes, Smooth Muscle | Cell Communication - drug effects | Endothelium, Vascular - pathology | Ethanolamines - therapeutic use | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Endothelial Cells - drug effects | Heart | Sects | Pulmonary hypertension | Endothelium | Studies | Cell growth | Pulmonary arteries | Mortality | Smooth muscle | Veins & arteries | Life Sciences
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 2012, Volume 186, Issue 8, pp. 780 - 789
Journal Article
European Respiratory Journal, ISSN 0903-1936, 11/2015, Volume 46, Issue 5, pp. 1242 - 1246
The loss of allograft function in the long term (whatever its pattern over time) not only remains the single major cause of death following lung... 
SYSTEM | BRONCHIOLITIS-OBLITERANS-SYNDROME | REPAIR | MANAGEMENT | RESPIRATORY SYSTEM | REGENERATION | MECHANISMS | DYSFUNCTION | EXPRESSION | PULMONARY-FIBROSIS | TRANSPLANTATION | Humans | Allografts
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 2015, Volume 192, Issue 8, pp. 983 - 997
Rationale: Inflammation and endothelial dysfunction are considered two primary instigators of pulmonary arterial hypertension (PAH). CD74 is a receptor for the... 
Macrophage migration inhibitory factor | CD74 signaling pathway | Endothelial dysfunction | Adhesion molecules | Pulmonary hypertension | CD74 | RECRUITMENT | macrophage migration inhibitory factor | pulmonary hypertension | PHENOTYPE | MIF | CELL-SURVIVAL | PREVENTS | endothelial dysfunction | FIBROBLAST GROWTH FACTOR-2 | adhesion molecules | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | MICE | CONTRIBUTES | CRITICAL CARE MEDICINE | Leukocytes, Mononuclear - metabolism | Up-Regulation | Humans | Macrophage Migration-Inhibitory Factors - immunology | Middle Aged | Macrophage Migration-Inhibitory Factors - metabolism | Male | Case-Control Studies | Familial Primary Pulmonary Hypertension - metabolism | Pulmonary Artery - metabolism | Familial Primary Pulmonary Hypertension - immunology | Leukocytes, Mononuclear - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | Adult | Female | Histocompatibility Antigens Class II - metabolism | Disease Models, Animal | Endothelium, Vascular - immunology | Vascular Cell Adhesion Molecule-1 - immunology | Signal Transduction | Endothelial Cells - metabolism | Intercellular Adhesion Molecule-1 - immunology | Cells, Cultured | Endothelium, Vascular - physiopathology | Rats | E-Selectin - metabolism | E-Selectin - immunology | Inflammation | Endothelial Cells - immunology | Intercellular Adhesion Molecule-1 - metabolism | Animals | Histocompatibility Antigens Class II - immunology | Endothelium, Vascular - metabolism | Antigens, Differentiation, B-Lymphocyte - metabolism | In Vitro Techniques | Vascular Cell Adhesion Molecule-1 - metabolism | Pulmonary Artery - immunology
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 07/2008, Volume 178, Issue 1, pp. 81 - 88
Journal Article
Circulation, ISSN 0009-7322, 09/2015, Volume 132, Issue 9, pp. 834 - 847
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2011, Volume 121, Issue 7, pp. 2888 - 2897
Multidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our... 
MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | THERAPY | MULTIDRUG-RESISTANCE PROTEINS | ENDOTHELIAL DYSFUNCTION | CHRONIC HYPOXIA | PHOSPHODIESTERASE TYPE-5 | ARTERIAL-HYPERTENSION | SMOOTH-MUSCLE-CELLS | CYCLIC-NUCLEOTIDES | CAMP | Propionates - metabolism | Humans | Leukotriene Antagonists - metabolism | Cyclic GMP-Dependent Protein Kinases - metabolism | Hypertension, Pulmonary - prevention & control | Vasodilation | RNA Interference | Multidrug Resistance-Associated Proteins - genetics | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Cyclic AMP - metabolism | Leukotriene Antagonists - therapeutic use | Cyclic AMP-Dependent Protein Kinases - metabolism | Lung - pathology | Enzyme Inhibitors - metabolism | Cells, Cultured | Propionates - therapeutic use | Vasoconstriction | Familial Primary Pulmonary Hypertension | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Muscle, Smooth, Vascular - cytology | Enzyme Inhibitors - therapeutic use | Mice, Knockout | Pulmonary Artery - cytology | Quinolines - metabolism | Animals | Cyclic GMP - metabolism | Hypoxia - pathology | Hypoxia - physiopathology | Mice | Quinolines - therapeutic use | Hypertension, Pulmonary - pathology | Multidrug Resistance-Associated Proteins - metabolism | Prevention | Physiological aspects | Cellular proteins | Research | Drug resistance | Pulmonary hypertension | Life Sciences | Human health and pathology | Pulmonology and respiratory tract
Journal Article