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PLoS ONE, ISSN 1932-6203, 06/2015, Volume 10, Issue 6, pp. e0130624 - e0130624
Neuroinflammation is the local reaction of the brain to infection, trauma, toxic molecules or protein aggregates. The brain resident macrophages, microglia,... 
INTERLEUKIN-1 | ACTIVATION | MOLECULAR PLATFORM | INHIBITION | DISTINCT PATHWAYS | NEUROINFLAMMATION | MULTIDISCIPLINARY SCIENCES | IL-1-BETA | MECHANISMS | RECEPTORS | NALP3 INFLAMMASOME | Microglia - metabolism | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Peptide Fragments - toxicity | Caspase 1 - metabolism | Interleukin-1alpha - metabolism | alpha-Synuclein - pharmacology | Interleukin-1beta - metabolism | Interleukin-1beta - secretion | Microglia - cytology | Brain - cytology | Interleukin-1beta - analysis | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Amyloid beta-Peptides - toxicity | Mice, Inbred C57BL | Cells, Cultured | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Caspase 1 - genetics | Caspase 1 - deficiency | Receptors, Purinergic P2X7 - metabolism | Mice | Interleukin-18 - metabolism | Astrocytes - metabolism | Cytokines | Health aspects | Nervous system diseases | Brain | Cell culture | Traumatic brain injury | Peptides | Aluminum sulfate | Homeostasis | Nervous system | Activation | Macrophages | Synuclein | Proteins | Rodents | Amyloid | Life sciences | Communication | Immune system | Neurodegenerative diseases | Astrocytes | Inflammation | Trauma | Molecular chains | Microglia | Interleukin 18 | Mode of action | Neurological diseases | Nigericin | Brain research | Ligands | Alum | Laboratory animals | Alzheimers disease | Chemokines | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2009, Volume 459, Issue 7245, pp. 433 - 436
Fungal infections represent a serious threat, particularly in immunocompromised patients. Interleukin-1 (IL-1 ) is a key pro-inflammatory factor in innate... 
RHEUMATOID-ARTHRITIS | CELLS | ACTIVATION | CANDIDA-ALBICANS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | INNATE IMMUNE-RESPONSE | RECEPTOR | MICE | INHIBITOR | NALP3 INFLAMMASOME | Potassium - metabolism | Reactive Oxygen Species - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 1 - metabolism | Monocytes - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Protein-Tyrosine Kinases - deficiency | Intracellular Signaling Peptides and Proteins - deficiency | Protein-Tyrosine Kinases - genetics | Candida albicans - physiology | Interleukin-1beta - biosynthesis | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Carrier Proteins - immunology | Signal Transduction | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Interleukin-1beta - immunology | Inflammation - immunology | Candida albicans - immunology | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Mice | Nigericin - pharmacology | Enzyme Activation | Protein-Tyrosine Kinases - antagonists & inhibitors | Mycoses | Research | Properties | Phosphotransferases | Cellular control mechanisms | Proteins | Studies | Fungi | E coli | Research & development--R&D | Clinical trials | Pattern recognition | Kinases | Cells
Journal Article
Nature, ISSN 0028-0836, 07/2009, Volume 460, Issue 7252, pp. 269 - 273
Journal Article