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Journal of Clinical Investigation, ISSN 0021-9738, 01/2016, Volume 126, Issue 1, pp. 35 - 37
The clinical application of T cell immunotherapy depends on ex vivo modification and expansion of T cells for adoptive transfer. In preclinical models, the use... 
Female | Immunologic Memory | T-Lymphocytes - immunology | Animals | Immunotherapy, Adoptive | Immune recognition | Research | Health aspects | Immunotherapy | Index Medicus | Abridged Index Medicus
Journal Article
Molecular Therapy, ISSN 1525-0016, 05/2014, Volume 22, Issue 5, pp. 899 - 900
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2016, Volume 126, Issue 1, pp. 35 - 35
  The clinical application of T cell immunotherapy depends on ex vivo modification and expansion of T cells for adoptive transfer. In preclinical models, the... 
Antigens | Cytokines | Lymphocytes | Immunotherapy | Leukemia | Response rates | T cell receptors | Genetic engineering | Manufacturing | Tumors
Journal Article
Molecular Therapy, ISSN 1525-0016, 06/2013, Volume 21, Issue 6, pp. 1114 - 1115
Administration of genetically modified T lymphocytes to cancer patients has increased exponentially over the past 15 years, and these cells have been given to... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | DISEASE | GENETICS & HEREDITY | GENE-TRANSFER | LEUKEMIA | DONOR LYMPHOCYTES | Animals | Mutagenesis, Insertional - methods | Retroviridae - genetics | T-Lymphocytes - metabolism | Lymphoma, T-Cell - therapy | Humans | Female | Lymphoma, T-Cell - genetics | Index Medicus
Journal Article
Blood, ISSN 0006-4971, 2009, Volume 114, Issue 8, pp. 1457 - 1458
The PD-1 pathway is emerging as an important tumor-evasion mechanism. In this issue of Blood, 3 independent groups report that PD-1 is highly expressed by... 
MEDIATED ANTITUMOR IMMUNITY | HEMATOLOGY | T-CELL EXHAUSTION | DISEASE PROGRESSION | LYMPHOCYTES
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2011, Volume 365, Issue 18, pp. 1673 - 1683
Journal Article
Human Gene Therapy, ISSN 1043-0342, 11/2009, Volume 20, Issue 11, pp. 1229 - 1239
“T-body” or chimeric antigen receptor (CAR) technology, which combines the specificity of an antibody with the homing, tissue penetration, and target cell... 
Reviews
Journal Article
Journal Article
Molecular Therapy, ISSN 1525-0016, 03/2017, Volume 25, Issue 3, pp. 580 - 592
Immunotherapy with T cells expressing the chimeric antigen receptor (CAR) specific for the CD19 antigen (CD19.CAR-Ts) is a very effective treatment in B cell... 
safety switch | chimeric antigen receptor | adoptive immunotherapy | MEDICINE, RESEARCH & EXPERIMENTAL | TRANSGENE | ARTIFICIAL DEATH SWITCHES | SUICIDE-GENE | TRANSPLANTATION | ENGINEERED DONOR LYMPHOCYTES | THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ACUTE LYMPHOBLASTIC-LEUKEMIA | IN-VIVO | EXPANSION | GENETICS & HEREDITY | SAFETY SWITCH | Neoplasms - metabolism | Caspase 9 - metabolism | Cell Proliferation | Humans | Apoptosis - genetics | Molecular Imaging | Lymphocyte Activation - immunology | Neoplasms - therapy | Neoplasms - genetics | T-Lymphocytes - metabolism | Receptors, Antigen, T-Cell - immunology | Gene Order | B-Lymphocytes - metabolism | Antigens, CD19 - immunology | Gene Expression | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Cell Survival | Hematopoietic Stem Cell Transplantation | Graft Survival | Protein Binding - immunology | Genetic Vectors - genetics | Animals | Apoptosis - immunology | B-Lymphocytes - immunology | Neoplasms - immunology | T-Lymphocytes - immunology | Mice | Receptors, Antigen, T-Cell - genetics | Cytotoxicity, Immunologic | Antigens | CD19 antigen | Cytokines | Leukemia | Caspase | Lymphocytes T | Experiments | Aplasia | Clonal deletion | Lymphocytes B | Lymphocytes | Immunotherapy | Caspase-9 | Conflicts of interest | Antitumor activity | Growth factors | Apoptosis | Index Medicus | Original
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 09/2017, Volume 127, Issue 9, pp. 3462 - 3471
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2017, Volume 25, Issue 9, pp. 2214 - 2224
Targeting disialoganglioside (GD2) on neuroblastoma (NB) with T cells expressing a first-generation chimeric antigen receptor (CAR) was safe, but the cells had... 
neuroblastoma | GD2-CAR | immunotherapy | MEDICINE, RESEARCH & EXPERIMENTAL | NKT CELLS | ANTI-GD2 ANTIBODY | ANTITUMOR-ACTIVITY | THERAPY | IMMUNOTHERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TUMOR-ASSOCIATED MACROPHAGES | SUPPRESSOR-CELLS | BLOCKADE | ANTIGEN RECEPTOR | STAGE 4 NEUROBLASTOMA | Antineoplastic Agents, Immunological - administration & dosage | Humans | Child, Preschool | Male | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neuroblastoma - mortality | Neuroblastoma - therapy | Lymphocyte Depletion | Molecular Targeted Therapy | Recombinant Fusion Proteins | Young Adult | T-Lymphocytes - metabolism | Neuroblastoma - immunology | Female | Child | Neuroblastoma - pathology | Cytokines - blood | Immunotherapy, Adoptive - adverse effects | Immunotherapy, Adoptive - methods | Receptors, Antigen, T-Cell - metabolism | Treatment Outcome | Combined Modality Therapy | Antineoplastic Agents, Immunological - adverse effects | Antineoplastic Agents, Immunological - therapeutic use | Adolescent | Lymphocyte Count | Myeloid Cells - metabolism | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | Transplantation Conditioning | Cohort Studies | Antigens | Lymphatic system | Myeloid cells | CD11b antigen | PD-1 protein | Lymphocytes T | Neuroblastoma | Metastasis | Patients | Fever | CD45 antigen | Blood | CD163 antigen | Cyclophosphamide | Pain | Fludarabine | Lymphocytes | Bone marrow | Antitumor activity | Movement disorders | Apoptosis | Neutropenia | Index Medicus | Original
Journal Article