X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
life sciences (48) 48
pharmaceutical sciences (31) 31
bioinformatics (26) 26
chemical sciences (26) 26
[info.info-bi]computer science [cs]/bioinformatics [q-bio.qm] (24) 24
[sdv.sp]life sciences [q-bio]/pharmaceutical sciences (24) 24
computer science (24) 24
[chim.chem]chemical sciences/cheminformatics (23) 23
[chim.ther]chemical sciences/medicinal chemistry (23) 23
cheminformatics (23) 23
chemistry (23) 23
index medicus (23) 23
medicinal chemistry (23) 23
organic chemistry (23) 23
metallurgy (21) 21
biochemistry & molecular biology (19) 19
humans (16) 16
peptides (16) 16
biochemistry (15) 15
amino acid sequence (13) 13
models, molecular (13) 13
molecular sequence data (13) 13
after-treatment of single crystals or a homogeneouspolycrystalline material with defined structure (12) 12
animals (12) 12
apparatus therefor (12) 12
beer (12) 12
compositions thereof (12) 12
crystal growth (12) 12
culture media (12) 12
enzymology (12) 12
microbiology (12) 12
microorganisms or enzymes (12) 12
mutation or genetic engineering (12) 12
production of a homogeneous polycrystalline material withdefined structure (12) 12
propagating, preserving or maintaining microorganisms (12) 12
refining by zone-melting of material (12) 12
single crystals or homogeneous polycrystalline material withdefined structure (12) 12
single-crystal-growth (12) 12
spirits (12) 12
unidirectional solidification of eutectic material orunidirectional demixing of eutectoid material (12) 12
vinegar (12) 12
wine (12) 12
biochemistry, molecular biology (10) 10
drug design (9) 9
heterocyclic compounds (9) 9
human necessities (9) 9
hygiene (9) 9
medical or veterinary science (9) 9
preparations for medical, dental, or toilet purposes (9) 9
specific therapeutic activity of chemical compounds ormedicinal preparations (9) 9
biophysics (8) 8
cellular biology (8) 8
chemistry, medicinal (8) 8
neurons and cognition (8) 8
pharmacology (8) 8
proteins (8) 8
binding sites (7) 7
multidisciplinary sciences (7) 7
algorithms (6) 6
computer science, interdisciplinary applications (6) 6
expression (6) 6
kinetics (6) 6
ligands (6) 6
neurobiology (6) 6
nucleoside-phosphate kinase - antagonists & inhibitors (6) 6
physiological aspects (6) 6
protein binding (6) 6
protein conformation (6) 6
protein structure, secondary (6) 6
protein structure, tertiary (6) 6
sequence homology, amino acid (6) 6
[sdv.bbm]life sciences [q-bio]/biochemistry, molecular biology (5) 5
antitubercular agents - pharmacology (5) 5
database (5) 5
female (5) 5
proteins - chemistry (5) 5
protozoan proteins - chemistry (5) 5
protozoan proteins - metabolism (5) 5
software (5) 5
structure-activity relationship (5) 5
thymidylate kinase (5) 5
user-computer interface (5) 5
[ sdv.bbm ] life sciences [q-bio]/biochemistry, molecular biology (4) 4
[sdv.neu]life sciences [q-bio]/neurons and cognition [q-bio.nc] (4) 4
antitubercular agents - chemical synthesis (4) 4
article (4) 4
biochemical research methods (4) 4
biotechnology & applied microbiology (4) 4
catalytic domain (4) 4
cell biology (4) 4
computer simulation (4) 4
databases, protein (4) 4
drug discovery (4) 4
enzyme inhibitors - pharmacology (4) 4
enzymes (4) 4
genetic algorithm (4) 4
genomics (4) 4
internet (4) 4
malaria (4) 4
membrane proteins - chemistry (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2018, Volume 9, Issue 3, pp. 204 - 209
Journal Article
Nucleic Acids Research, ISSN 1362-4962, 07/2010, Volume 38, pp. W615 - W621
e-LEA3D web server integrates three complementary tools to perform computer-aided drug design based on molecular fragments. In drug discovery projects, there... 
Journal Article
Bioinformatics, ISSN 1367-4803, 9/2008, Volume 24, Issue 18, pp. 2101 - 2102
Journal Article
Nature, ISSN 0028-0836, 10/2012, Volume 490, Issue 7421, pp. 552 - 555
Polypeptide toxins have played a central part in understanding physiological and physiopathological functions of ion channels(1,2). In the field of pain, they... 
EVOLUTION | ALIGNMENT | MULTIDISCIPLINARY SCIENCES | TOXINS | MECHANISMS | PROTEINS | HIPPOCAMPAL-NEURONS | ACTIVATED CURRENTS | ASIC3 | Elapid Venoms - chemistry | Analgesics - pharmacology | Acid Sensing Ion Channels - classification | Acid Sensing Ion Channel Blockers - pharmacology | Molecular Sequence Data | Acid Sensing Ion Channel Blockers - chemistry | Male | Pain - metabolism | Peptides - administration & dosage | Protein Subunits - metabolism | Pain - drug therapy | Oocytes - drug effects | Analgesics - adverse effects | Injections, Spinal | Analgesics - therapeutic use | Morphine - pharmacology | Peptides - chemistry | Acid Sensing Ion Channel Blockers - therapeutic use | Oocytes - metabolism | Mice, Inbred C57BL | Xenopus laevis | Drug Tolerance | Rats | Elapid Venoms - therapeutic use | Elapid Venoms - pharmacology | Respiratory Insufficiency - chemically induced | Nociceptors - chemistry | Peptides - pharmacology | Animals | Elapid Venoms - administration & dosage | Analgesics - chemistry | Naloxone - pharmacology | Acid Sensing Ion Channels - genetics | Mice | Nociceptors - metabolism | Protein Subunits - antagonists & inhibitors | Morphine - adverse effects | Peptides - therapeutic use | Acid Sensing Ion Channels - metabolism | Physiological aspects | Ion channels | Genetic aspects | Peptides | Properties | Venom | Spinal cord | Toxins | Crystal structure | Medicinal Chemistry | Life Sciences | Cheminformatics | Computer Science | Bioinformatics | Chemical Sciences | Pharmaceutical sciences
Journal Article
Nature Reviews Nephrology, ISSN 1759-5061, 07/2019, Volume 15, Issue 7, pp. 412 - 422
Mutations in the polycystins PC1 or PC2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid-filled... 
CONFORMATIONAL-CHANGES | GENE | ION-CHANNEL | UROLOGY & NEPHROLOGY | RECEPTOR | MECHANOSENSATION | AUTOSOMAL-DOMINANT | EF-HAND DOMAIN | CALCIUM-DEPENDENCE | PKD2 | PRIMARY CILIA | Life Sciences | Human health and pathology | Quantitative Methods | Urology and Nephrology
Journal Article
Cell, ISSN 0092-8674, 10/2019, Volume 179, Issue 2, pp. 340 - 354
The conversion of force into an electrical cellular signal is mediated by the opening of different types of mechanosensitive ion channels (MSCs), including... 
TMC1 | HAIR-CELLS | TREK-1 | MECHANOSENSITIVE CHANNEL | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANOTRANSDUCTION CHANNEL | PIEZO2 | TRAAK | TOUCH | BLOOD-PRESSURE | CELL BIOLOGY | Ion channels | Life Sciences | Cellular Biology | Subcellular Processes
Journal Article
Nature Reviews Nephrology, ISSN 1759-507X, 2019
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6041, pp. 463 - 467
Apicomplexan parasites such as Toxoplasma gondii and Plasmodium species actively invade host cells through a moving junction (MJ) complex assembled at the... 
Receptors | Obligate parasites | REPORTS | Cell membranes | Parasitism | Parasites | Parasite hosts | APICAL MEMBRANE ANTIGEN-1 | COMPLEX | MULTIDISCIPLINARY SCIENCES | MOVING JUNCTION | TOXOPLASMA-GONDII | INHIBITORY ANTIBODY | ERYTHROCYTE | Antigens, Protozoan - immunology | Molecular Sequence Data | Toxoplasma - ultrastructure | Antigens, Protozoan - metabolism | Protozoan Proteins - metabolism | Toxoplasma - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Antigens, Protozoan - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Host-Parasite Interactions | Toxoplasma - metabolism | Antibodies, Monoclonal - immunology | Plasmodium falciparum - chemistry | Amino Acid Sequence | Peptide Fragments - metabolism | Antigens, Protozoan - chemistry | Protein Structure, Secondary | Antibodies, Protozoan - immunology | Models, Molecular | Membrane Proteins - immunology | Toxoplasma - pathogenicity | Peptide Fragments - chemistry | Membrane Proteins - chemistry | Mutagenesis | Hydrophobic and Hydrophilic Interactions | Plasmodium falciparum - pathogenicity | Protein Binding | Protein Conformation | Protozoan Proteins - immunology | Amino Acid Substitution | Physiological aspects | Cell receptors | Research | Peptides | Medicinal Chemistry | Life Sciences | Cheminformatics | Computer Science | Bioinformatics | Chemical Sciences | Pharmaceutical sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14628 - 14633
Journal Article
Nature Communications, ISSN 2041-1723, 09/2016, Volume 7, Issue 1, p. 12777
Cyclophilins are peptidyl-prolyl cis/trans isomerases (PPIase) that catalyse the interconversion of the peptide bond at proline residues. Several cyclophilins... 
APOPTOSIS | MITOCHONDRIAL PERMEABILITY TRANSITION | DESIGN | CYCLOSPORINE-A | REPLICATION | GENOTYPE | MULTIDISCIPLINARY SCIENCES | T-CELL-ACTIVATION | DRUG DISCOVERY | MECHANISMS | ALISPORIVIR | Analytical chemistry | Chemical Sciences
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 2019
Mechanotransduction plays a key role in vascular development, physiology and disease states. Piezo1 is a mechanosensitive non-selective cationic channel... 
Life Sciences | Pharmacology | Pharmaceutical sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0144764
Plasmodium falciparum is an obligate intracellular protozoan parasite that employs a highly sophisticated mechanism to access the protective environment of the... 
AMA1 | EVENTS | APICOMPLEXAN PARASITES | MULTIDISCIPLINARY SCIENCES | MOVING JUNCTION | CELL INVASION | VACCINE | MALARIA PARASITE INVASION | MEMBRANE ANTIGEN 1 | ERYTHROCYTE INVASION | PLASTICITY | Temperature | Peptides - genetics | Half-Life | Molecular Sequence Data | Multiprotein Complexes - genetics | Protozoan Proteins - genetics | Antigens, Protozoan - metabolism | Multiprotein Complexes - metabolism | Thermodynamics | Peptides - metabolism | Protozoan Proteins - metabolism | Plasmodium falciparum - genetics | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Receptors, Cell Surface - chemistry | Antigens, Protozoan - genetics | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Protein Stability | Amino Acid Sequence | Antigens, Protozoan - chemistry | Peptides - chemistry | Protein Structure, Secondary | Membrane Proteins - genetics | Models, Molecular | Receptors, Cell Surface - metabolism | Binding Sites - genetics | Multiprotein Complexes - chemistry | Algorithms | Membrane Proteins - chemistry | Anisotropy | Protein Binding | Calorimetry | Kinetics | Receptors, Cell Surface - genetics | Complex formation | Rate constants | Peptides | Erythrocytes | Fluorescence | Amino acids | Biochemistry | Vaccines | Parasites | Apical membrane antigen 1 | Experiments | Proteins | E coli | Reaction kinetics | Crystal structure | Half life | Antigens | Malaria | Titration calorimetry | Radioactive half-life | Chromatography | Ron protein | Membrane proteins | Ligands | Titration | Binding sites | Medicinal Chemistry | Life Sciences | Cheminformatics | Computer Science | Bioinformatics | Chemical Sciences | Pharmaceutical sciences
Journal Article