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Development (Cambridge, England), ISSN 0950-1991, 03/2017, Volume 144, Issue 6, pp. 968 - 975
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 07/2018, Volume 18, Issue 7, pp. 407 - 418
Journal Article
Nature Protocols, ISSN 1754-2189, 02/2016, Volume 11, Issue 2, pp. 347 - 58
This protocol describes a strategy for the generation of 3D prostate organoid cultures from healthy mouse and human prostate cells (either bulk or FACS-sorted... 
PROGENITOR CELLS | MURINE PROSTATE | STEM-CELLS | IN-VITRO | VIVO | REGENERATION | EXPANSION | BIOCHEMICAL RESEARCH METHODS | Epithelial Cells - physiology | Organ Culture Techniques - methods | Animals | Organoids - growth & development | Humans | Cells, Cultured | Culture Media, Serum-Free | Male | Mice | Time | Prostate - physiology | Cell culture | Care and treatment | Prostate cancer | Methods
Journal Article
Nature, ISSN 0028-0836, 2015, Volume 521, Issue 7550, pp. 43 - 37
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, pp. 352 - 354
Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this... 
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2016, Volume 63, Issue 3, pp. 352 - 4
Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this... 
STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENOME | INTRATUMOR HETEROGENEITY | CELL BIOLOGY | Mutation | Humans | Oncogenes | Clustered Regularly Interspaced Short Palindromic Repeats | Genetic aspects | Genes | Bar codes | Cancer
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2016, Volume 1481, pp. 141 - 59
We established an in vitro culture model in which intestinal epithelial stem cells can grow into three-dimensional, ever-expanding epithelial organoids that... 
Wnt signaling | CRISPR/Cas9 | Organoids | Intestine | Lentivirus | Cell Differentiation - genetics | Animals | Wnt Signaling Pathway - genetics | Humans | Organoids - metabolism | Organoids - cytology | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Mice | Genetic Vectors | Cell Culture Techniques - methods
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 08/2019, Volume 38, Issue 15, pp. e101654 - n/a
Journal Article
EMBO molecular medicine, ISSN 1757-4684, 2016, Volume 8, Issue 7, pp. 745 - 760
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 12, pp. E2357 - E2364
Journal Article
Nature Cell Biology, ISSN 1465-7392, 04/2010, Volume 12, Issue 4, pp. 380 - 389
Journal Article