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Journal Article
Journal Article
Annual Reports in Medicinal Chemistry, ISSN 0065-7743, 2017, Volume 50, pp. 263 - 299
Phenotypic screening is now reestablished in academia and industry as an approach to discover novel drug targets, pathways, and high-quality hit and lead... 
Chemical biology | High-content screening | Physiological relevance | Phenotypic screening | Target inference | Target discovery | Molecular mechanism of action | Target deconvolution | Drug discovery | Target agonistic | Biological diversity | iPS cells | PROGENITOR CELLS | DESIGN | POTENT | CHEMISTRY, MEDICINAL | INHIBITION | DRUGS | TARGETS | PHARMACOLOGY & PHARMACY | LIGAND | DISCOVERY
Journal Article
Molecular Therapy, ISSN 1525-0016, 01/2012, Volume 20, Issue 1, pp. 138 - 145
Journal Article
STEM CELLS Translational Medicine, ISSN 2157-6564, 02/2016, Volume 5, Issue 2, pp. 164 - 174
To understand and exploit cardiac ontogeny for drug discovery efforts, an in vitro human induced pluripotent stem cell‐derived cardiac progenitor cell (CPC)... 
High throughput screening | Phenotypic screening | Stem cells | Assay development | Proliferation | Drug discovery | Differentiation | MYOCARDIUM | SMALL-MOLECULE | LINEAGES | CELL & TISSUE ENGINEERING | HYPERTROPHY | SMOOTH-MUSCLE | POTENT | HEART REGENERATION | THERAPY | CARDIOMYOCYTE | Small Molecule Libraries - pharmacology | Receptors, Transforming Growth Factor beta - genetics | Homeodomain Proteins - metabolism | Humans | Vascular Endothelial Growth Factor Receptor-2 - genetics | Dose-Response Relationship, Drug | Protein Kinase Inhibitors - chemistry | Transfection | Proto-Oncogene Proteins c-kit - deficiency | Proto-Oncogene Proteins c-kit - genetics | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Biomarkers - metabolism | Gene Expression | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Transcription Factors - genetics | Plasmids - metabolism | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Homeobox Protein Nkx-2.5 | Small Molecule Libraries - chemistry | Phenotype | High-Throughput Screening Assays | Myocytes, Cardiac - drug effects | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Cell Differentiation - drug effects | Plasmids - chemistry | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Primary Cell Culture | Heart | Heart failure | Cell proliferation | Data analysis | Heart attacks | Cloning | Transforming growth factor-a | Cardiomyocytes | Smooth muscle | Ontogeny | Biology | Progenitor cells | Manuscripts | 20th century | Writing | Growth factors | Pluripotency | Cell-Based Drug Development, Screening, and Toxicology
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2019, Volume 14, Issue 8, p. 810
Innovative therapeutic modalities for pharmacological intervention of transforming growth factor [beta] (TGF[beta])-dependent diseases are of great value.... 
Heart | Transforming growth factors
Journal Article
ChemMedChem, ISSN 1860-7179, 04/2019, Volume 14, Issue 8, pp. 796 - 796
The Front Cover shows b‐annelated 1,4‐dihydropyridines as unique degraders of type II TGFβ receptors that might serve as novel therapeutic modalities after... 
TGFβ receptor | engineered heart tissue | 1,4-dihydropyridines | cardiac progenitor cells | hit-to-lead
Journal Article
Tissue Engineering Part A, ISSN 1937-3341, 06/2012, Volume 18, Issue 11-12, pp. 111 - 1108
Stem cell therapy for tissue repair is a rapidly evolving field and the factors that dictate the physiological responsiveness of stem cells remain under... 
Original Articles | Heart | Myocardial infarction | Animal models | Cell survival | Tissue engineering | coronary artery | Muscle contraction | Angiogenesis | Donors | Mechanical loading | Fibrosis | Stem cells | Myocardium | Mechanical stimuli | Vascular endothelial growth factor
Journal Article
Journal Article
Cell Stem Cell, ISSN 1934-5909, 06/2019, Volume 24, Issue 6, pp. 895 - 907.e6
We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with... 
drug development | cholesterol | cardiomyocyte proliferation | pluripotent stem cells | statin | organoid
Journal Article
Circulation, ISSN 0009-7322, 11/2016, Volume 134, Issue Suppl_1 Suppl 1, pp. A18674 - A18674
IntroductionOver 5 million people in the United States are affected by heart failure, a consequence of the heart’s limited ability to regenerate functional... 
Journal Article