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1. Full Text Translation of the Philadelphia chromosome into therapy for CML
by Druker, Brian J
Blood, ISSN 0006-4971, 12/2008, Volume 112, Issue 13, pp. 4808 - 4817
Throughout its history, chronic myeloid leukemia (CML) has set precedents for cancer research and therapy. These range from the identification of the first... 
CHRONIC MYELOGENOUS LEUKEMIA | ABL-POSITIVE CELLS | IMATINIB-RESISTANT | BCR-ABL | TYROSINE KINASE INHIBITOR | IDIOPATHIC HYPEREOSINOPHILIC SYNDROME | NILOTINIB FORMERLY AMN107 | HEMATOLOGY | PHENYLAMINO-PYRIMIDINE PAP | CHRONIC MYELOID-LEUKEMIA | CHRONIC MYELOMONOCYTIC LEUKEMIA | Piperazines - history | History, 21st Century | History, 20th Century | Humans | Biomedical Research - history | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Pyrimidines - pharmacology | Drug Delivery Systems - history | Imatinib Mesylate | Piperazines - pharmacology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - history | Pyrimidines - history | Benzamides | Philadelphia Chromosome - drug effects | Drug Delivery Systems - methods | Protein-Tyrosine Kinases - antagonists & inhibitors
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2. Full Text Reply to N. Cerveira et al
by Berman, Ellin and Berman, Ellin and Druker, Brian J and Druker, Brian J and Burwick, Richard and Burwick, Richard
Journal of Clinical Oncology, ISSN 0732-183X, 01/2019, Volume 37, Issue 1, pp. 90 - 91
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3. Full Text Janet Rowley (1925-2013)
by Druker, Brian J
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 484 - 484
United States | History, 20th Century | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Genetics, Medical - history | Piperazines - therapeutic use | Neoplasms - history | Imatinib Mesylate | Benzamides - therapeutic use | Neoplasms - genetics | Pyrimidines - therapeutic use | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Myeloid, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Translocation, Genetic - genetics
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4. Full Text OBITUARY: Janet Rowley (1925-2013)
by Brian J Druker
Nature, ISSN 0028-0836, 01/2014, Volume 505, Issue 7484, p. 484
  Aged 75, instead of dwelling on her seminal work on chronic myeloid leukaemia, she told me about new pathogenetic mechanisms of acute myeloid leukaemia that... 
Transplants & implants | Bone marrow | Chromosomes
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5. Full Text Function of ASXL1 Mutations in Chronic Neutrophilic Leukemia
by Braun, Theodore and Foley, Amy and Druker, Brian J and Maxson, Julia E
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3067 - 3067
Abstract Mutations in Additional Sex Combs Like 1 are frequent in myeloid malignancy and are associated with poor prognosis. We find ASXL1 mutations to be... 
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6. Full Text Reply to D.M. Ross et al and V. Florou et al
by Berman, Ellin and Druker, Brian J and Burwick, Richard
Journal of Clinical Oncology, ISSN 0732-183X, 09/2018, Volume 36, Issue 25, pp. 2660 - 2661
Pregnancy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Protein-Tyrosine Kinases | Humans
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7. Full Text Imatinib as a Paradigm of Targeted Therapies
by Druker, Brian J
2004, ISBN 0120066912, Volume 91
Imatinib (Gleevec) exemplifies the successful development of a rationally designed, molecularly targeted therapy for the treatment of a specific cancer. This... 
Piperazines - administration & dosage | Gastrointestinal Neoplasms - drug therapy | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Patient Selection | Enzyme Inhibitors - administration & dosage | Drug Design | Antineoplastic Agents - pharmacology | Drug Evaluation, Preclinical | Oncogenes | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Pyrimidines - administration & dosage | Enzyme Inhibitors - pharmacology | Models, Molecular | Neoplasms - enzymology | Clinical Trials as Topic | Piperazines - therapeutic use | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Imatinib Mesylate | Piperazines - pharmacology | Neoplasms - drug therapy | Animals | Fusion Proteins, bcr-abl - physiology | Pyrimidines - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Protein Conformation | Mice | Benzamides | Protein-Tyrosine Kinases - antagonists & inhibitors
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8. Full Text Janet Rowley : geneticist who discovered that broken chromosomes cause cancer
by Druker, Brian J
Nature, ISSN 0028-0836, 01/2014, Volume 505, Issue 7484, p. 484
Appreciation | Geneticists
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9. Full Text Revisiting NTRKs as an emerging oncogene in hematological malignancies
by Joshi, Sunil K and Davare, Monika A and Druker, Brian J and Tognon, Cristina E
Leukemia, ISSN 0887-6924, 09/2019
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10. Full Text Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis
by Scholl, Benjamin and Liu, Hong Yan and Long, Brian R and McCarty, Owen J. T and O'Hare, Thomas and Druker, Brian J and Vu, Tania Q
ACS Nano, ISSN 1936-0851, 06/2009, Volume 3, Issue 6, pp. 1318 - 1328
Western blot | Immunoblot | Quantum dot | Proteomics | Electrophoresis | Single molecule
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11. Full Text Philadelphia Chromosome-Positive Leukemias: From Basic Mechanisms to Molecular Therapeutics
by Kurzrock, Razelle and Kantarjian, Hagop M and Druker, Brian J and Talpaz, Moshe
Annals of Internal Medicine, ISSN 0003-4819, 05/2003, Volume 138, Issue 10, pp. 819 - 830
The Philadelphia chromosome translocation (t(9;22)) results in the molecular juxtaposition of two genes, BCR and ABL, to form an aberrant BCR-ABL gene on... 
CHRONIC MYELOGENOUS LEUKEMIA | MEDICINE, GENERAL & INTERNAL | COLONY-STIMULATING FACTOR | ABL TYROSINE KINASE | ACUTE LYMPHOBLASTIC-LEUKEMIA | FOCAL ADHESION KINASE | GROUP-B PROTEIN | BREAKPOINT CLUSTER REGION | GASTROINTESTINAL STROMAL TUMORS | FACTOR-RECEPTOR-BETA | CHRONIC MYELOID-LEUKEMIA | Genetic Therapy | Translocation, Genetic | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Antineoplastic Agents - therapeutic use | Piperazines - therapeutic use | Chromosomes, Human, Pair 9 | Imatinib Mesylate | Animals | Pyrimidines - therapeutic use | Models, Animal | Chromosomes, Human, Pair 22 | Benzamides | Genes, abl - physiology | Philadelphia Chromosome | Protein-Tyrosine Kinases - antagonists & inhibitors | Physiological aspects | Genetic aspects | Chronic myeloid leukemia | Drug therapy | Proteins | Therapy | Leukemia | Genes
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12. Full Text Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia
by Chang, Bill H and Leonard, Jessica and Wolf, Joelle and Degnin, Michelle and Lenz, Kyle and Wilmot, Beth and Mullighan, Charles G and Loh, Mignon L and Hunger, Stephen P and Tyner, Jeffrey W and Druker, Brian J
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 4026 - 4026
Abstract Acute Lymphoblastic Leukemia (ALL) harboring the t(17;19)(q22;p13) is a rare subtype of leukemia with a dismal prognosis. This recurring translocation... 
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13. Imatinib as a paradigm of targeted cancer therapies
by Druker, Brian J
2007, Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease
Signal Transduction | Receptor Protein-Tyrosine Kinases
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14. Imatinib as a paradigm of targeted cancer therapies
by Druker, Brian J
2007, Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease
Signal Transduction | Receptor Protein-Tyrosine Kinases
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15. Full Text Dual Inhibition of Bruton's Tyrosine Kinase and BCL2: A Promising Therapeutic Strategy for Myeloid and Lymphoid Leukemias
by Eide, Christopher A and Kurtz, Stephen E and Kaempf, Andy and Tognon, Cristina E and Mori, Motomi and Gordon, Max J and Tyner, Jeffrey W and Danilov, Alexey V and Druker, Brian J
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 214 - 214
Abstract Background: The identification of effective therapies based on targeted interventions for human cancers faces the challenges of genetic and epigenetic... 
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16. Full Text T-Cell Suppression By Src/ABL Kinase Inhibitors When Combined with Blinatumomab in Ph+ Acute Lymphoblastic Leukemia
by Leonard, Jessica and Kosaka, Yoko and Malla, Pavani and Hayes-Lattin, Brandon and Lamble, Adam J and Druker, Brian J and Tyner, Jeffrey W and Chang, Bill H and Lind, Evan F
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2694 - 2694
Abstract Introduction: Targeted ABL kinase inhibitors (TKIs) have shown great activity in Ph+ Acute Lymphoblastic Leukemia (Ph+ ALL), however relapsed disease... 
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17. Full Text Determining the sensitivity of primary acute myeloid leukemia (AML) samples with FLT3-ITD or FLT3-D835 mutations to FLT3 inhibitors using an ex vivo drug sensitivity screen
by Rosenberg, Mara and Fan, Guang and Watanabe-Smith, Kevin and Tognon, Cristina and Druker, Brian J and Tyner, Jeffrey and Loriaux, Marc
Journal of Clinical Oncology, ISSN 0732-183X, 05/2018, Volume 36, Issue 15_suppl, pp. 7025 - 7025
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18. Full Text Abstract 1980: S116836 overcomes BCR-ABL T315I mutation mediated imatinib resistance in chronic myeloid leukemia
by Gupta, Pranav and Zhang, Guannan and Barbuti, Anna Maria and Ding, Ke and Pan, Jingxuan and Druker, Brian J and Chen, Zhe-Sheng
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 1980 - 1980
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19. Full Text Characterization of Transforming NTRK2 and NTRK3 Mutations Identified in Leukemia Patient Samples
by Qian, Kristin and Tognon, Cristina E and Wagner, Jacob and Davare, Monika and Druker, Brian J
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1566 - 1566
Abstract Overview The neurotrophin receptor tyrosine kinases (NTRK) play a seminal role in central nervous system development, but are expressed in various... 
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20. Full Text Combining p38MAPK Inhibitors with a Second Targeted Agent Enhances Blockade of Inflammatory Signaling-Mediated Survival in Acute Myeloid Leukemia Cells
by Kurtz, Stephen E and Eide, Christopher A and Dubey, Narain P and Kaempf, Andy and McWeeney, Shannon K and Tognon, Cristina E and Mori, Motomi and Druker, Brian J and Tyner, Jeffrey W and Agarwal, Anupriya
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2726 - 2726
Abstract Background : Various pro-inflammatory and stress-related stimuli activate p38 mitogen-activated protein kinase (p38MAPK), triggering cascades of cell... 
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