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Frontiers in Physiology, ISSN 1664-042X, 08/2018, Volume 9, p. 1055
Transient receptor potential-6 channels are widely expressed cation channels that play a role in regulating Ca2+ dynamics, especially during G protein-coupled... 
Calcium signaling | TRPC6 | G protein signaling | Mesangial cells | Podocytes | Mechanotransduction | Vascular smooth muscle | TRP channels | DIACYLGLYCEROL | ACTIVATION | PHYSIOLOGY | vascular smooth muscle | STRETCH | mechanotransduction | calcium signaling | ANGIOTENSIN-II | IDENTIFICATION | mesangial cells | CATION CHANNELS | podocytes | CALCIUM | PODOCIN | EXPRESSION | Cellular signal transduction | Ion channels | Research | G proteins
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 08/2018
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 02/2015, Volume 87, Issue 2, pp. 231 - 239
Journal Article
Nephrology Dialysis Transplantation, ISSN 0931-0509, 10/2015, Volume 30, Issue 10, pp. 1630 - 1638
L-Glutamate (L-Glu) plays an essential role in the central nervous system (CNS) as an excitatory neurotransmitter, and exerts its effects by acting on a large... 
homocysteine | NMDA | glomerulosclerosis | excitotoxicity | glutamate | CELLS | NMDA RECEPTOR | ACTIVATION | ACID | GLOMERULAR-FILTRATION | PODOCYTES | TRANSPLANTATION | SPINAL-CORD NEURONS | UROLOGY & NEPHROLOGY | HYPERHOMOCYSTEINEMIC RATS | CHANNELS | METHYL-D-ASPARTATE | Receptors, Glutamate - metabolism | Kidney - metabolism | Glutamic Acid - metabolism | Mice | Animals | Humans
Journal Article
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN 0167-4889, 12/2015, Volume 1853, Issue 12, p. 3294
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2014, Volume 229, Issue 4, pp. 434 - 442
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 02/2012, Volume 302, Issue 3, pp. F298 - F307
Kim EY, Anderson M, Dryer SE. Insulin increases surface expression of TRPC6 channels in podocytes: role of NADPH oxidases and reactive oxygen species. Am J... 
Focal and segmental glomerulosclerosis | Diabetes | CELLS | BKCA CHANNELS | ACTIVATION | PHYSIOLOGY | PORPHYRINS | CURRENTS | focal and segmental glomerulosclerosis | NAD(P)H OXIDASE | GLUCOSE | ROS | UROLOGY & NEPHROLOGY | GLOMERULAR-FILTRATION RATE | diabetes | UP-REGULATION | Free Radical Scavengers - pharmacology | Reactive Oxygen Species - metabolism | Hypoglycemic Agents - metabolism | Cations - metabolism | Glomerulosclerosis, Focal Segmental - genetics | NADPH Oxidases - metabolism | Metalloporphyrins - pharmacology | NADPH Oxidases - genetics | Glomerulosclerosis, Focal Segmental - physiopathology | TRPC Cation Channels - genetics | Membrane Potentials - drug effects | Cell Line | Insulin - pharmacology | RNA, Small Interfering - pharmacology | Imidazoles - pharmacology | NADPH Oxidase 4 | Calcium Channel Blockers - pharmacology | Membrane Potentials - physiology | Glomerulosclerosis, Focal Segmental - metabolism | Hydrogen Peroxide - metabolism | Hypoglycemic Agents - pharmacology | Podocytes - cytology | Insulin - metabolism | Patch-Clamp Techniques | Animals | Podocytes - physiology | TRPC Cation Channels - metabolism | Mice | TRPC Cation Channels - physiology | Oxidases | Reactive oxygen species | NADP (Coenzyme) | Physiological aspects | Genetic aspects | Ion channels | Research | Gene expression | Health aspects | Insulin | Call for Papers
Journal Article
American Journal of Physiology, ISSN 0363-6143, 11/2013, Volume 305, Issue 9, p. C960
  Canonical transient receptor potential-6 (TRPC6) channels have been implicated in the pathophysiology of glomerular diseases. TRPC6 channels are typically... 
Oxygen | Lipids | Ribonucleic acid--RNA | Cells | Cholesterol
Journal Article
American Journal of Physiology, ISSN 0363-6143, 08/2013, Volume 305, Issue 3, p. C276
  Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene... 
Membranes | Genes | T cell receptors | Biochemistry | Mutation | Ribonucleic acid--RNA
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 05/2014, Volume 306, Issue 9, pp. F1088 - F1097
Extracellular ATP may contribute to Ca2+ signaling in podocytes during tubuloglomerular feedback (TGF) and possibly as a result of local tissue damage. TRPC6... 
Podocyte | Trpc6 | Purinergic | Glomerular filtration | Nadph oxidase | Podocin | DIACYLGLYCEROL | CELLS | glomerular filtration | PHYSIOLOGY | TRPC6 | podocin | TUBULOGLOMERULAR FEEDBACK | FILTRATION | CALCIUM WAVE | INHIBITION | purinergic | NADPH oxidase | podocyte | DYNAMICS | UROLOGY & NEPHROLOGY | NA+ | MICE | EXPRESSION | Reactive Oxygen Species - metabolism | Type C Phospholipases - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Type C Phospholipases - antagonists & inhibitors | Gene Knockdown Techniques | Phospholipase A2 Inhibitors - pharmacology | Dose-Response Relationship, Drug | Transfection | RNA Interference | Adenosine Triphosphate - metabolism | Membrane Proteins - metabolism | Receptors, Purinergic P2Y - drug effects | TRPC Cation Channels - genetics | Intracellular Signaling Peptides and Proteins - genetics | Calcium Signaling | Purinergic P2Y Receptor Antagonists - pharmacology | Cell Line | Podocytes - metabolism | Membrane Proteins - genetics | Receptors, Purinergic P2Y - metabolism | Rats | Phospholipases A2 - metabolism | Antioxidants - pharmacology | Rats, Sprague-Dawley | Animals | Membrane Potentials | Podocytes - drug effects | TRPC Cation Channels - metabolism | Mice | Ion Channel Gating - drug effects | Physiological aspects | Reactive oxygen species | Ion channels | Adenosine triphosphatase
Journal Article
Journal of Neurophysiology, ISSN 0022-3077, 05/2007, Volume 97, Issue 5, pp. 3508 - 3516
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 07/2008, Volume 295, Issue 1, pp. F235 - F246
Journal Article
FEBS Letters, ISSN 0014-5793, 10/2009, Volume 583, Issue 19, pp. 3109 - 3114
MINT‐7260414: Slo1 (uniprotkb:Q08460) physically interacts (MI:0915) with NKbeta1 (uniprotkb:P08251) by two hybrid (MI:0018) 
ciliary ganglion | Ion transporter | CG | Trafficking | ATPase | Na+/K+-ATPase β1 subunit | NKα | large conductance Ca2+-activated K+ channels | KCNMA1 | Na+/K+-ATPase α-subunit | BKCa | NKβ1 | Potassium channel | potassium channel | trafficking | ion transporter
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 08/2013, Volume 305, Issue 3, pp. C276 - C289
Gain-of-function mutations in the transient receptor potential (TRP) cation channel subfamily C member 6 (TRPC6) gene and mutations in the NPHS2 gene encoding... 
Podocyte | Glomerular filtration | TRPC6 | Mechanosensitive | Slit diaphragm | glomerular filtration | BKCA CHANNELS | PHYSIOLOGY | PROTEIN | mechanosensitive | NEPHRIN | CAPILLARY WALL | SURFACE EXPRESSION | RECEPTOR | CELL BIOLOGY | GLOMERULAR SLIT DIAPHRAGM | CATION CHANNELS | podocyte | slit diaphragm | MUTATIONS | NEPHROTIC SYNDROME | ortho-Aminobenzoates - pharmacology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Spider Venoms - pharmacology | Cytochalasin D - pharmacology | Type C Phospholipases - antagonists & inhibitors | Nephrotic Syndrome | Diglycerides - pharmacology | RNA Interference | Estrenes - pharmacology | Pyrrolidinones - pharmacology | HEK293 Cells | Kidney Glomerulus - metabolism | Cell Membrane - metabolism | Membrane Proteins - metabolism | TRPC Cation Channels - genetics | Intracellular Signaling Peptides and Proteins - genetics | Phospholipase A2 Inhibitors | Guanosine Diphosphate - pharmacology | Cell Line | Podocytes - metabolism | Membrane Proteins - genetics | Phosphodiesterase Inhibitors - pharmacology | Rats | Imidazoles - pharmacology | Thionucleotides - pharmacology | Calcium Channel Blockers - pharmacology | Cinnamates - pharmacology | Peptides - pharmacology | Animals | Guanosine Diphosphate - analogs & derivatives | TRPC Cation Channels - metabolism | Chlorobenzoates - pharmacology | Mice | RNA, Small Interfering | Mutation | Ion Channel Gating
Journal Article
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