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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 10/2017, Volume 27, Issue 20, pp. 4622 - 4625
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2265 - 2269
An X-ray crystal structure of one of our previously discovered RORγt inverse agonists bound to the RORγt ligand binding domain revealed that the cyclohexane... 
Th17 | Inverse agonist | Retinoic acid-related orphan receptor gamma t | IL-17 | RORγt | AUTOIMMUNE | DESIGN | CHEMISTRY, MEDICINAL | ROR gamma t | CHEMISTRY, ORGANIC | PSORIASIS | DISCOVERY
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2017, Volume 27, Issue 14, pp. 3101 - 3106
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, p. 2265
An X-ray crystal structure of one of our previously discovered ROR[gamma]t inverse agonists bound to the ROR[gamma]t ligand binding domain revealed that the... 
Hydrogen | Crystals | Cyclohexane | Structure | Tretinoin
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 03/2019, Volume 10, Issue 3, pp. 367 - 373
A new phenyl (3-phenylpyrrolidin-3-yl)sulfone series of ROR gamma t inverse agonists was discovered utilizing the binding conformation of previously reported... 
pyrrolidin-3-ylsulfone | X-ray crystallography | inverse agonist | structure-based design | RORγt | CHEMISTRY, MEDICINAL | ROR gamma t
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 10/2007, Volume 35, Issue 10, pp. 1916 - 1925
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 5, pp. 1577 - 1582
Novel ((2-substituted-1 -benzo[ ]imidazol-1-yl)methyl)benzamides were found to be excellent P1′ substituents in conjunction with unique constrained β-amino... 
MMP | TACE | Matrix metalloprotease | TNF modulator | TNF-α Converting Enzyme
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2007, Volume 17, Issue 10, p. 2769
We have discovered novel hydantoins, triazolones, and imidazolones that are druglike, non-hydroxamate inhibitors of the Zn-metalloprotease TACE with nM... 
Care and treatment | Adenosine triphosphatase | Cancer | Tumors
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2018, Volume 28, Issue 2, pp. 85 - 93
We disclose the optimization of a high throughput screening hit to yield benzothiazine and tetrahydroquinoline sulfonamides as potent RORγt inverse agonists.... 
POTENT | AUTOIMMUNE | CHEMISTRY, MEDICINAL | INHIBITION | INTERLEUKIN-17 | NUCLEAR RECEPTORS | MODULATORS | DISEASE | GENE-EXPRESSION | CHEMISTRY, ORGANIC | DISCOVERY | PSORIASIS | Rheumatoid factor | Multiple sclerosis | Sulfonamides | Analysis | Gastrointestinal diseases | Liver | Arthritis
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2015, Volume 58, Issue 10, pp. 4278 - 4290
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2014, Volume 24, Issue 24, pp. 5721 - 5726
Journal Article
Journal Article
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