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Tetrahedron Letters, ISSN 0040-4039, 06/2016, Volume 57, Issue 22, pp. 2390 - 2394
[Display omitted] •Solvent and palladium free microwave-assisted direct CH amination was reported.•N-Unsubstituted 1H-indazoles instead of N-aryl 1H-indazoles... 
Microwave assisted | 1H-Indazole | C[sbnd]H amination | Silica-supported manganese dioxide | Silica
Journal Article
Journal of Computer-Aided Molecular Design, ISSN 0920-654X, 8/2019, Volume 33, Issue 8, pp. 775 - 785
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 10/2006, Volume 128, Issue 39, pp. 12652 - 12653
Conjugate addition reactions of a wide range of nucleophilic enol species with enones, catalyzed by a cinchona alkaloid derived thiourea organocatalyst, have... 
CATALYSIS | ACTIVATION | ACID | MALONATE | ESTERS | NITROALKANES | ASYMMETRIC MICHAEL ADDITION | CHEMISTRY, MULTIDISCIPLINARY | NITROMETHANE | Alkenes - chemistry | Esters - chemistry | Ketones - chemical synthesis | Stereoisomerism | Ketones - chemistry | Nitriles - chemistry | Catalysis | Esters - chemical synthesis | Nitrogen compounds | Nucleophilic reactions | Observations | Properties
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 2018
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2007, Volume 6, Issue 9, pp. 2429 - 2440
This study is intended to characterize the cellular target of gambogic acid (GA), a natural product isolated from the gamboge resin of Garcinia hurburyi tree,... 
antitumor agent | DNA cleavage | topoisomerase II catalytic inhibitor | gambogic acid | ATP hydrolysis | DRUG-SENSITIVITY | CELLS | ETOPOSIDE | ENZYME | ONCOLOGY | MEDIATED DNA CLEAVAGE | SEQUENCE SPECIFICITY | GYRASE-B PROTEIN | TRANSCRIPTASE MESSENGER-RNA | CYTOTOXICITY | CANCER-THERAPY
Journal Article
Letters in Drug Design and Discovery, ISSN 1570-1808, 2018, Volume 15, Issue 9, pp. 945 - 950
Journal Article
Organic Letters, ISSN 1523-7060, 10/2005, Volume 7, Issue 21, pp. 4713 - 4716
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2019, Volume 164, p. 317
Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a... 
Epigenetic inheritance | Arginine | Methyltransferases | Leukemia | Resveratrol | Lymphomas | Drug discovery
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 06/2016, Volume 57, Issue 22, pp. 2390 - 2394
An effective and convenient method has been developed for the preparation of 1-unsubstituted 1H-indazoles via C-H amination of N-acetylhydrazones in the... 
C-H amination | Microwave assisted | 1H-Indazole | Silica-supported manganese dioxide | OXIDATION | POTENT | INDAZOLES | CHEMISTRY, ORGANIC | 1H-INDAZOLES | INHIBITOR | Silica | Palladium
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 20, pp. 9085 - 9104
Fibroblast growth factor receptors (FGFR1–4) are promising therapeutic targets in many cancers. With the resurgence of interest in irreversible inhibitors,... 
CH5183284/DEBIO 1347 | AZD4547 | SELECTIVE INHIBITOR | DESIGN | CHEMISTRY, MEDICINAL | COVALENT INHIBITORS | JNJ-42756493 | OVERCOME RESISTANCE | DERIVATIVES | EGFR | STRATEGIES
Journal Article
Phytotherapy Research, ISSN 0951-418X, 03/2008, Volume 22, Issue 3, pp. 407 - 415
Shikonin, a naphthoquinone pigment isolated from the Chinese herbal therapeutic, Zicao, has been shown to exhibit antioxidant and anticancer effects. In this... 
apoptosis | caspase family | NF‐κB | oral squamous cell carcinoma (OSCC) | growth inhibition | Shikonin | Caspase family | NF-κB | Oral squamous cell carcinoma (OSCC) | Growth inhibition | Apoptosis | SURVIVAL | ACTIVATION | CHEMISTRY, MEDICINAL | ANGIOGENESIS | NATURAL-PRODUCTS | ALPHA | NF-kappa B | THERAPY | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | CANCER STATISTICS | BCL-2 FAMILY | TUMOR-GROWTH
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 10/2008, Volume 350, Issue 14‐15, pp. 2194 - 2198
Journal Article
Journal Article