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Science, ISSN 0036-8075, 12/2017, Volume 358, Issue 6368, pp. 1332 - 1336
Journal Article
Immunity, ISSN 1074-7613, 2002, Volume 17, Issue 5, pp. 537 - 547
We report intriguing aspects of the contribution of IL-15Rα to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-15Rα, these two... 
BETA-CHAIN | NATURAL-KILLER | INTERLEUKIN-15 | RECEPTOR-ALPHA-CHAIN | MICE | IMMUNOLOGY | ENDOCYTOSIS | EXPRESSION | BINDING | T-CELLS | GAMMA-CHAIN
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2009, Volume 106, Issue 18, pp. 7513 - 7518
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2018, Volume 115, Issue 46, pp. E10915 - E10924
The goal of cancer immunotherapy is to stimulate the host immune system to attack malignant cells. Antibody-dependent cellular cytotoxicity (ADCC) is a pivotal... 
interleukin-15 | macrophages | NK cells | antibody-dependent cellular cytotoxicity | cancer immunotherapy | NATURAL-KILLER-CELLS | FC-GAMMA-RIV | MULTIDISCIPLINARY SCIENCES | MONOCLONAL-ANTIBODY | ANTITUMOR-ACTIVITY | RECEPTOR ENGAGEMENT DRIVES | BETA-CHAIN | MURINE MODEL | ANTI-CD40 ANTIBODY | GROWTH-FACTOR | THERAPEUTIC ACTIVITY | Interleukin-15 - administration & dosage | Alemtuzumab - administration & dosage | Humans | Mice, Inbred C57BL | Antibody-Dependent Cell Cytotoxicity - immunology | Male | Mice, SCID | Interleukin-15 - immunology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Rituximab - administration & dosage | Animals | Cell Line, Tumor | Killer Cells, Natural - immunology | Female | Macrophages - drug effects | Mice, Inbred NOD | Killer Cells, Natural - drug effects | Mice | Antibody-Dependent Cell Cytotoxicity - drug effects | Antibodies, Monoclonal - immunology | Macrophages - immunology | Viral antibodies | Killer cells | Care and treatment | Immunotherapy | Physiological aspects | Antibodies | Interleukin-15 | Macrophages | Methods | Cancer | Adult T cell leukemia | Animal models | Toxicity | Leukemia | Xenotransplantation | Clinical trials | Cytotoxicity | Activation | Malignancy | Lymphocytes T | Metastases | Infusion | Cell activation | Lymphocytes | Xenografts | Natural killer cells | Immune system | Medical research | Cytokines | Rituximab | Interleukin 15 | Lymphoma | Cells | Effectors | Monoclonal antibodies | CD20 antigen | Antitumor activity | Tumors | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, pp. e102793 - e102793
NK cells are able to form a functional memory suggesting that some NK cells are surviving the activation process. We hypothesized that NK cell activation... 
NATURAL-KILLER-CELLS | DIFFERENTIAL EXPRESSION | MULTIPLE-SCLEROSIS | DENDRITIC CELLS | CD56(BRIGHT) | MULTIDISCIPLINARY SCIENCES | CLASS-I | SUBSETS | IL-15 | PERIPHERAL-BLOOD | INHIBITORY RECEPTORS | Tumor Necrosis Factor-alpha - metabolism | Cytokines - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Lymphocyte Activation | Coculture Techniques | Granzymes - metabolism | Mice, Inbred C57BL | Interleukin-15 - pharmacology | Phenotype | Animals | Melanoma, Experimental - immunology | Interleukin-10 - metabolism | Interleukin-2 - pharmacology | Killer Cells, Natural - immunology | Female | Mice | Perforin - metabolism | Cytotoxicity, Immunologic | Receptors, Interleukin-18 - metabolism | Fc receptors | Killer cells | Cytokines | Comparative analysis | Tumors | CD27 antigen | Lymphocyte receptors | Multiple sclerosis | Toxicity | Homeostasis | Cytotoxicity | Activation | Blood | CD90 antigen | Cell activation | Granzyme B | Interleukin 2 | Lymphocytes | CD25 antigen | Biocompatibility | Natural killer cells | Perforin | Medical research | CD11c antigen | Lymphatic system | CD11b antigen | Dendritic cells | Granulocyte-macrophage colony-stimulating factor | Melanoma | CD62L protein | T cell receptors | Exposure | Tumor necrosis factor-α | Metabolism | Gene expression | Interleukin 18 receptors | Interleukin 18 | CD16 antigen | Exhaustion | γ-Interferon | Lysis | Interleukin 10 | Ligands | Cancer | Index Medicus
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 01/2015, Volume 33, Issue 1, pp. 74 - 82
Journal Article
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2019, Volume 25, Issue 16, pp. 4945 - 4954
PURPOSEThe first-in-human clinical trial with human bolus intravenous infusion IL15 (rhIL15) was limited by treatment-associated toxicity. Here, we report... 
Index Medicus
Journal Article