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Blood, ISSN 0006-4971, 2013, Volume 122, Issue 15, pp. 2539 - 2549
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2014, Volume 124, Issue 11, pp. 4867 - 4876
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 24, pp. 3583 - 3586
Chronic lymphocytic leukemia (CLL) displays constitutive phosphatidylinositol 3-kinase (PI3K) activation resulting from aberrant regulation of B-cell receptor... 
IBRUTINIB | MODELS | INHIBITOR | HEMATOLOGY | THERAPEUTIC TARGET | Class I Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases - metabolism | T-Lymphocytes - enzymology | Class Ib Phosphatidylinositol 3-Kinase - genetics | Protein-Tyrosine Kinases - metabolism | Humans | Cell Survival - genetics | Male | Neoplasm Proteins - antagonists & inhibitors | Killer Cells, Natural - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Mutation, Missense | Neoplasm Proteins - metabolism | Protein-Tyrosine Kinases - genetics | Isoquinolines - pharmacology | Female | Antineoplastic Agents - pharmacology | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Tumor Cells, Cultured | Neoplasm Proteins - genetics | Pyrazoles - pharmacology | Cell Survival - drug effects | B-Lymphocytes - enzymology | Purines - pharmacology | Enzyme Inhibitors - pharmacology | Signal Transduction - genetics | Pyrimidines - pharmacology | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Killer Cells, Natural - enzymology | Drug Resistance, Neoplasm - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Amino Acid Substitution | Drug Resistance, Neoplasm - drug effects | Lymphoid Neoplasia | Brief Report
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 300 - 300
Abstract Introduction Treatment of CLL is rapidly evolving, now including oral targeted agents and novel combinations. However, complete response (CR) rates... 
Journal Article
Blood, ISSN 0006-4971, 06/2014, Volume 123, Issue 25, pp. 3988 - 3998
Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown... 
CRITERIA | CORD BLOOD TRANSPLANTATION | CHRONIC GVHD | CLINICAL-TRIALS | DIFFERENTIATION | ANTIBODY-RESPONSES | ICOS | HEMATOLOGY | VERSUS-HOST-DISEASE | IL-21 | CONSENSUS DEVELOPMENT PROJECT | Germinal Center - immunology | Receptors, Interleukin-21 - genetics | Germinal Center - drug effects | Graft vs Host Disease - metabolism | Bronchiolitis Obliterans - metabolism | Graft vs Host Disease - immunology | CD40 Ligand - immunology | Interleukins - metabolism | CD4-Positive T-Lymphocytes - immunology | T-Lymphocytes, Helper-Inducer - drug effects | Graft vs Host Disease - genetics | Interleukins - genetics | Bronchiolitis Obliterans - genetics | CD40 Antigens - metabolism | CD40 Ligand - metabolism | Flow Cytometry | Inducible T-Cell Co-Stimulator Ligand - metabolism | T-Lymphocytes, Helper-Inducer - immunology | Interleukins - immunology | Inducible T-Cell Co-Stimulator Protein - genetics | Antibodies, Monoclonal - immunology | B-Lymphocytes - metabolism | Inducible T-Cell Co-Stimulator Protein - immunology | Antigens, CD20 - immunology | Inducible T-Cell Co-Stimulator Ligand - immunology | Receptors, CXCR5 - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Receptors, CXCR5 - genetics | Receptors, Interleukin-21 - immunology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | CD4-Positive T-Lymphocytes - metabolism | Bronchiolitis Obliterans - immunology | Receptors, Interleukin-21 - metabolism | Antigens, CD20 - metabolism | Receptors, CXCR5 - immunology | Syndrome | Mice, Knockout | B-Lymphocytes - drug effects | Microscopy, Confocal | Animals | B-Lymphocytes - immunology | Germinal Center - metabolism | Mice | Inducible T-Cell Co-Stimulator Protein - metabolism | Chronic Disease | CD40 Antigens - immunology | Transplantation
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2017, Volume 35, Issue 15_suppl, pp. 7524 - 7524
Journal Article
Journal Article
Seminars in Hematology, ISSN 0037-1963, 2014, Volume 51, Issue 3, pp. 206 - 218
The pathogenesis and progression of normal B-cell development to malignant transformation of chronic lymphocytic leukemia (CLL) is still poorly understood and... 
SELECTIVE REGULATION | PROTEIN | FOSTAMATINIB DISODIUM | CHRONIC LYMPHOCYTIC-LEUKEMIA | TYROSINE KINASE INHIBITOR | C-BETA INHIBITOR | PHASE-II | HEMATOLOGY | NF-KAPPA-B | ANTIGEN RECEPTOR | ENZASTAURIN LY317615
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 07/2015, Volume 14, Issue 7 Supplement, pp. B44 - B44
Journal Article
The Prostate, ISSN 0270-4137, 12/2007, Volume 67, Issue 16, pp. 1781 - 1790
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2015, Volume 290, Issue 10, pp. 5960 - 5978
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 19, pp. 3308 - 3316
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 3866 - 3866
Abstract Abstract 3866 Chronic lymphocytic leukemia (CLL) is an incurable accumulation of malignant B-lymphocytes in peripheral circulation, which home to... 
Journal Article