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1. Mechanistic and pharmacological characterization of PF-04457845: A highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain
by Ahn, Kay and Smith, Sarah E and Liimatta, Marya B and Beidler, David and Sadagopan, Nalini and Dudley, David T and Young, Tim and Wren, Paul and Zhang, Yanhua and Swaney, Steven and Van Becelaere, Keri and Blankman, Jacqueline L and Nomura, Daniel K and Bhattachar, Shobha N and Stiff, Cory and Nomanbhoy, Tyzoon K and Weerapana, Eranthie and Johnson, Douglas S and Cravatt, Benjamin F
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2011, Volume 338, Issue 1, pp. 114 - 124
The endogenous cannabinoid (endocannabinoid) anandamide is principally degraded by the integral membrane enzyme fatty acid amide hydrolase (FAAH).... 
ALPHA-KETOHETEROCYCLE INHIBITORS | NEUROPATHIC PAIN | ANANDAMIDE HYDROLYSIS | ENZYMES | IN-VIVO | FAAH INHIBITOR | PHARMACOLOGY & PHARMACY | MICE | REVERSIBLE INHIBITORS | COMPLEX PROTEOMES | BLOCKADE | Inflammation - pathology | Humans | Male | Pyridazines - pharmacology | Urea - chemistry | Pain - enzymology | Piperidines - pharmacology | Inflammation - drug therapy | Pain - drug therapy | Enzyme Inhibitors - chemistry | Urea - analogs & derivatives | Pyridazines - therapeutic use | Amidohydrolases - metabolism | Piperidines - chemistry | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Rats | Amidohydrolases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Rats, Sprague-Dawley | Pyridazines - chemistry | Urea - therapeutic use | Animals | Piperidines - therapeutic use | Mice | Inflammation - enzymology | Urea - pharmacology
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2. Full Text 300 - Serrated Epithelial Change in Ulcerative Colitis Patients is Associated with High Rate of Colonic Dysplasia
by Parian, Alyssa M and Chowdhury, Reezwana and Rubin, David T and Razvi, Mohammed A and Truta, Brindusa and Melia, Joanna P and Pezhouh, Maryam Kherad and Dudley-Brown, Sharon and Brant, Steven R and Lazarev, Mark
Gastroenterology, ISSN 0016-5085, 04/2017, Volume 152, Issue 5, pp. S76 - S76
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3. Full Text Serrated Epithelial Change in Ulcerative Colitis Patients is Associated with High Rate of Colonic Dysplasia
by Parian, Alyssa M and Chowdhury, Reezwana and Rubin, David T and Razvi, Mohammed A and Truta, Brindusa and Melia, Joanna P and Pezhouh, Maryam Kherad and Dudley-Brown, Sharon and Brant, Steven R and Lazarev, Mark
Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 5, pp. S76 - S76
Gastroenterology and Hepatology | Dysplasia | Ulcerative colitis
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4. Full Text Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
by Tecle, Haile and Pavlovsky, Alexander and Mueller, W Thomas and Barrett, Stephen and Whitehead, Christopher and Zhang, Erli and Omer, Charles and Warmus, Joseph and Leung, Iris K and Yan, Chunhong and Chen, Huifen and Ohren, Jeffrey F and McConnell, Patrick and Delaney, Amy and Dudley, David T and Kuffa, Peter and Spessard, Cindy and Hasemann, Charles A and Banotai, Craig and Sebolt-Leopold, Judith and Flamme, Cathlin and Kaufman, Michael
Nature Structural & Molecular Biology, ISSN 1545-9993, 12/2004, Volume 11, Issue 12, pp. 1192 - 1197
MEK1 and MEK2 are closely related, dual-specificity tyrosine/threonine protein kinases found in the Ras/Raf/MEK/ERK mitogen-activated protein kinase (MAPK)... 
MECHANISM | RECOGNITION | SPECIFICITY | CRYSTAL-STRUCTURE | TYROSINE KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CASCADE | IDENTIFICATION | CELL BIOLOGY | BIOPHYSICS | PATHWAY | GROWTH | ACTIVATED PROTEIN-KINASES | MAP Kinase Kinase 1 - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | MAP Kinase Kinase 2 - chemistry | MAP Kinase Kinase 1 - chemistry | MAP Kinase Kinase 2 - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Protein Structure, Quaternary | Conserved Sequence | Molecular Structure | Structural Homology, Protein | Binding Sites | Dimerization | Physiological aspects | Cellular signal transduction | Research | Structure | Protein kinases
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5. Full Text KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: Maintenance of Bw4 specificity since the divergence of apes and old world monkeys
by Schafer, Jamie L and Colantonio, Arnaud D and Neidermyer, William J and Dudley, Dawn M and Connole, Michelle and O'Connor, David H and Evans, David T
Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 4, pp. 1907 - 1917
The identification of MHC class I ligands for rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to our basic understanding of KIR and MHC... 
MHC CLASS-I | VIRUS-INFECTION | NK CELLS | KIR HAPLOTYPES | HLA-B | DOWN-REGULATION | MAJOR HISTOCOMPATIBILITY COMPLEX | HIV-1 NEF PROTEIN | IMMUNOLOGY | IMMUNOGLOBULIN-LIKE RECEPTOR | RAPID EVOLUTION | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Receptors, KIR - genetics | Jurkat Cells | Humans | HLA-B Antigens - immunology | Histocompatibility Antigens Class I - immunology | Macaca mulatta - immunology | Molecular Sequence Data | Protein Binding - immunology | Histocompatibility Antigens Class I - metabolism | Animals | Macaca mulatta - genetics | Killer Cells, Natural - immunology | Ligands | Epitopes, T-Lymphocyte - immunology | Killer Cells, Natural - metabolism | Receptors, KIR - immunology | Epitopes, T-Lymphocyte - metabolism
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6. Full Text Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
by Brant, Steven R and Okou, David T and Simpson, Claire L and Cutler, David J and Haritunians, Talin and Bradfield, Jonathan P and Chopra, Pankaj and Prince, Jarod and Begum, Ferdouse and Kumar, Archana and Huang, Chengrui and Venkateswaran, Suresh and Datta, Lisa W and Wei, Zhi and Thomas, Kelly and Herrinton, Lisa J and Klapproth, Jan-Micheal A and Quiros, Antonio J and Seminerio, Jenifer and Liu, Zhenqiu and Alexander, Jonathan S and Baldassano, Robert N and Dudley-Brown, Sharon and Cross, Raymond K and Dassopoulos, Themistocles and Denson, Lee A and Dhere, Tanvi A and Dryden, Gerald W and Hanson, John S and Hou, Jason K and Hussain, Sunny Z and Hyams, Jeffrey S and Isaacs, Kim L and Kader, Howard and Kappelman, Michael D and Katz, Jeffry and Kellermayer, Richard and Kirschner, Barbara S and Kuemmerle, John F and Kwon, John H and Lazarev, Mark and Li, Ellen and Mack, David and Mannon, Peter and Moulton, Dedrick E and Newberry, Rodney D and Osuntokun, Bankole O and Patel, Ashish S and Saeed, Shehzad A and Targan, Stephan R and Valentine, John F and Wang, Ming-Hsi and Zonca, Martin and Rioux, John D and Duerr, Richard H and Silverberg, Mark S and Cho, Judy H and Hakonarson, Hakon and Zwick, Michael E and McGovern, Dermot P.B and Kugathasan, Subra
Gastroenterology, ISSN 0016-5085, 2016, Volume 152, Issue 1, pp. 206 - 217.e2
Background & Aims The inflammatory bowel diseases (IBD) ulcerative colitis (UC) and Crohn’s disease (CD) cause significant morbidity and are increasing in... 
Gastroenterology and Hepatology | Trans-Ethnic | SNP | Genetic Analysis | Risk Factor | CROHNS-DISEASE | VARIANTS | ULCERATIVE-COLITIS | GENES | RISK | KOREANS | IMMUNOCHIP ANALYSIS | GASTROENTEROLOGY & HEPATOLOGY | Crohn Disease - genetics | Interleukin-12 Subunit p40 - genetics | Sorting Nexins - genetics | Tenascin - genetics | Humans | Colitis, Ulcerative - genetics | Receptors, Virus - genetics | Genotyping Techniques | HLA-DQ alpha-Chains - genetics | Case-Control Studies | Receptors, Chemokine - genetics | Receptors, Prostaglandin E, EP4 Subtype - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | HLA-DRB1 Chains - genetics | African Americans - genetics | Repressor Proteins - genetics | Ubiquitin Thiolesterase - genetics | Receptors, Interleukin - genetics | Cell Adhesion Molecules, Neuronal - genetics | KCNQ2 Potassium Channel - genetics | Polymorphism, Single Nucleotide | Adenylyl Cyclases - genetics | GPI-Linked Proteins - genetics | Receptors, CXCR6 | Medical research | Gastrointestinal diseases | Genomics | African Americans | Genetic research | Medicine, Experimental | Disease susceptibility | genetic analysis | Risk factor
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7. A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies
by David T Dudley and Xiao-Yan Li and Casey Y Hu and Celina G Kleer and Amanda L Willis and Stephen J Weiss
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 41, p. 14882
  Efforts to develop unbiased screens for identifying novel function-blocking monoclonal antibodies (mAbs) in human carcinomatous states have been hampered by... 
Tissue | Collagen | Monoclonal antibodies | Breast cancer | Tumors
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8. Full Text Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice
by Kinsey, Steven G and Naidu, Pattipati S and Cravatt, Benjamin F and Dudley, David T and Lichtman, Aron H
Pharmacology, Biochemistry and Behavior, ISSN 0091-3057, 10/2011, Volume 99, Issue 4, pp. 718 - 725
Fatty acid amide hydrolase (FAAH) is the primary degradative enzyme of the endocannabinoid anandamide ( -arachidonoylethanolamine), which activates cannabinoid... 
Fatty acid amide hydrolase (FAAH) | Endocannabinoid | Chronic inflammation | Inflammatory pain | Collagen-induced arthritis | Anandamide | RHEUMATOID-ARTHRITIS | SQUIRREL-MONKEYS | ANANDAMIDE HYDROLYSIS | INHIBITOR URB597 | NEUROSCIENCES | INDUCED PAW EDEMA | NEUROPATHIC PAIN | PRECIPITATED WITHDRAWAL | ACTIVATED-RECEPTOR-ALPHA | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | CANNABINOID-INDUCED ANTINOCICEPTION | Arthritis, Experimental - genetics | Amidohydrolases - genetics | Bornanes - pharmacology | Receptor, Cannabinoid, CB2 - drug effects | Amidohydrolases - antagonists & inhibitors | Genotype | Male | Pain Measurement - drug effects | Hot Temperature | Mice, Knockout | Arthritis, Experimental - pathology | Phenotype | Animals | Hyperalgesia - drug therapy | Amidohydrolases - physiology | Arthritis, Experimental - prevention & control | Receptor, Cannabinoid, CB1 - drug effects | Mice, Inbred DBA | Benzamides - pharmacology | Mice | Foot - pathology | Carbamates - pharmacology | Pyrazoles - pharmacology | Enzymes | Rheumatoid factor | Hydrolases | Arthritis | Fatty acids | Analysis | collagen-induced arthritis | endocannabinoid | inflammatory pain | fatty acid amide hydrolase (FAAH) | anandamide | chronic inflammation
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9. Full Text Quality indicators for inflammatory bowel disease: Development of process and outcome measures
by Melmed, Gil Y and Siegel, Corey Allan and Spiegel, Brennan M and Allen, John I and Cima, Robert and Colombel, Jean-Frederic and Dassopoulos, Themistocles and Denson, Lee A and Dudley-Brown, Sharon and Garb, Andrew and Hanauer, Stephen B and Kappelman, Michael D and Lewis, James D and Lynch, Isabelle and Moynihan, Amy and Rubin, David T and Sartor, R. Balfour and Schwartz, Ronald M and Wolf, Douglas C and Ullman, Thomas A
Inflammatory Bowel Diseases, ISSN 1078-0998, 03/2013, Volume 19, Issue 3, pp. 662 - 668
Introduction: Variation in adherence to management guidelines for inflammatory bowel disease (IBD) suggests variable quality of care. Quality indicators (QIs)... 
Inflammatory bowel disease | Quality | Quality indicators | Crohn's disease | Quality measures | Quality of care | Ulcerative colitis | SET | MANAGEMENT | CROHNS-DISEASE | ULCERATIVE-COLITIS | GUIDELINES | ADULTS | EXPERTS | quality indicators | quality of care | inflammatory bowel disease | quality | CHILDREN | ARTHRITIS CARE | quality measures | ulcerative colitis | GASTROENTEROLOGY & HEPATOLOGY | OF-CARE | Group Processes | Outcome and Process Assessment (Health Care) | United States | Humans | Patient Safety | Quality Indicators, Health Care | Quality of Life | Inflammatory Bowel Diseases - therapy | Practice Guidelines as Topic
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10. Full Text The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901
by Barrett, Stephen D and Bridges, Alexander J and Dudley, David T and Saltiel, Alan R and Fergus, James H and Flamme, Cathlin M and Delaney, Amy M and Kaufman, Michael and LePage, Sophie and Leopold, Wilbur R and Przybranowski, Sally A and Sebolt-Leopold, Judith and Van Becelaere, Keri and Doherty, Annette M and Kennedy, Robert M and Marston, Dan and Howard, W. Allen and Smith, Yvonne and Warmus, Joseph S and Tecle, Haile
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2008, Volume 18, Issue 24, pp. 6501 - 6504
A novel series of benzhydroxamic esters were identified as potent MEK inhibitors. Optimization of these esters produced the two clinical candidates and . A... 
MEK | Benzhydroxamate ester | CI-1040 | Mitogen-activated protein kinase | Oncology | PD 0325901 | MAP/ERK kinase | Hydroxamate ester | Anthranilic acid | ERK | CHEMISTRY, MEDICINAL | MAP KINASE | CHEMISTRY, ORGANIC | COLON | CANCER | PATHWAY | PROGRESS | FLUORINE | Neoplasm Transplantation | Chemistry, Pharmaceutical - methods | Diphenylamine - pharmacology | ortho-Aminobenzoates - chemistry | Benzoates - chemistry | Enzyme Inhibitors - pharmacology | Solubility | Hydroxamic Acids - chemistry | Enzyme Inhibitors - chemical synthesis | Benzamides - chemical synthesis | Diphenylamine - analogs & derivatives | Animals | Drug Design | Cell Line, Tumor | Inhibitory Concentration 50 | Benzamides - pharmacology | Mice | MAP Kinase Kinase Kinase 1 - antagonists & inhibitors | Diphenylamine - chemical synthesis | Esters | Mitogens | Index Medicus
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11. Full Text Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor
by Johnson, Douglas S and Stiff, Cory and Lazerwith, Scott E and Kesten, Suzanne R and Fay, Lorraine K and Morris, Mark and Beidler, David and Liimatta, Marya B and Smith, Sarah E and Dudley, David T and Sadagopan, Nalini and Bhattachar, Shobha N and Kesten, Stephen J and Nomanbhoy, Tyzoon K and Cravatt, Benjamin F and Ahn, Kay
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 02/2011, Volume 2, Issue 2, pp. 91 - 96
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase that degrades the fatty acid amide family of signaling lipids, including the... 
endocannabinoid | FAAH | irreversible inhibitor | clinical candidate | ALPHA-KETOHETEROCYCLE INHIBITORS | TARGET | URB597 | CHEMISTRY, MEDICINAL | MECHANISM | ANANDAMIDE | INACTIVATION | ENZYME | ACID AMIDE HYDROLASE | ESTERS | CHEMISTRY
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12. Full Text A 3D matrix platform for the rapid generation of therapeutic anti-human carcinoma monoclonal antibodies
by David T. Dudley and Xiao-Yan Li and Casey Y. Hu and Celina G. Kleer and Amanda L. Willis and Stephen J. Weiss
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2014, Volume 111, Issue 41, pp. 14882 - 14887
Efforts to develop unbiased screens for identifying novel functionblocking monoclonal antibodies (mAbs) in human carcinomatous states have been hampered by the... 
Antigens | Cell growth | Carcinoma | Collagens | Cell lines | Bones | Breast cancer | Metastasis | Integrins | Tumors | Extracellular matrix | Mouse model | Bone | MDA-MB-231 | mouse model | ALPHABETA INTEGRIN | INTEGRIN ALPHA-2-BETA-1 | BREAST-CANCER METASTASIS | MULTIDISCIPLINARY SCIENCES | CELL INVASION | bone | I COLLAGEN | SIGNALING PROMOTES | DEFICIENT MOUSE | metastasis | PROSTATE-CANCER | EXTRACELLULAR-MATRIX | extracellular matrix | BASEMENT-MEMBRANE | Cell Proliferation | Breast Neoplasms - immunology | Humans | Bone Neoplasms - secondary | Integrin alpha2 - metabolism | Transcriptome - genetics | Bone Neoplasms - pathology | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Mice, Nude | Chickens | Antigens, Neoplasm - metabolism | Cell Line, Tumor | Immunoassay - methods | Female | Antibodies, Monoclonal - immunology | Extravasation of Diagnostic and Therapeutic Materials | Three-dimensional display systems | Usage | Oncology, Experimental | Monoclonal antibodies | Development and progression | Models | Research | Health aspects | Cancer | Biological Sciences
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13. Full Text Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease
by Brant, Steven R and Okou, David T and Simpson, Claire L and Cutler, David J and Haritunians, Talin and Bradfield, Jonathan P and Chopra, Pankaj and Prince, Jarod and Begum, Ferdouse and Kumar, Archana and Huang, Chengrui and Venkateswaran, Suresh and Datta, Lisa W and Wei, Zhi and Thomas, Kelly and Herrinton, Lisa J and Klapproth, Jan-Micheal A and Quiros, Antonio J and Seminerio, Jenifer and Liu, Zhenqiu and Alexander, Jonathan S and Baldassano, Robert N and Dudley-Brown, Sharon and Cross, Raymond K and Dassopoulos, Themistocles and Denson, Lee A and Dhere, Tanvi A and Dryden, Gerald W and Hanson, John S and Hou, Jason K and Hussain, Sunny Z and Hyams, Jeffrey S and Isaacs, Kim L and Kader, Howard and Kappelman, Michael D and Katz, Jeffry and Kellermayer, Richard and Kirschner, Barbara S and Kuemmerle, John F and Kwon, John H and Lazarev, Mark and Li, Ellen and Mack, David and Mannon, Peter and Moulton, Dedrick E and Newberry, Rodney D and Osuntokun, Bankole O and Patel, Ashish S and Saeed, Shehzad A and Targan, Stephan R and Valentine, John F and Wang, Ming-Hsi and Zonca, Martin and Rioux, John D and Duerr, Richard H and Silverberg, Mark S and Cho, Judy H and Hakonarson, Hakon and Zwick, Michael E and McGovern, Dermot P. B and Kugathasan, Subra
Gastroenterology, ISSN 0016-5085, 6/2017, Volume 152, Issue 8, pp. 2082 - 2083
Trans-Ethnic | SNP | Genetic Analysis | Risk Factor
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