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NATURE COMMUNICATIONS, ISSN 2041-1723, 07/2019, Volume 10, Issue 1, pp. 3070 - 17
CARD9 and CARD11 drive immune cell activation by nucleating Bcl10 polymerization, but are held in an autoinhibited state prior to stimulation. Here, we... 
DOMAIN | PROTEIN | C-TYPE LECTIN | RECOGNITION | HELICAL RECONSTRUCTION | NMR-SPECTROSCOPY | CARMA1 | MULTIDISCIPLINARY SCIENCES | T-CELL-RECEPTOR | TORSION ANGLE DYNAMICS | NF-KAPPA-B | Coils | Cell activation | Filaments | Bcl-10 protein | Polymerization | Caspase | Activation | Disruption | Mutation | Immune system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2016, Volume 113, Issue 28, pp. 7858 - 7863
Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal p30... 
GsdmD | Caspase-11 | Pyroptosis | DOMAIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | PLATFORMS | caspase-11 | NONCANONICAL INFLAMMASOME ACTIVATION | PERFRINGOLYSIN-O | CELL-DEATH | pyroptosis | MICRODOMAINS | LEADS | INTRACELLULAR LPS | BINDING | Animals | Caspases - metabolism | Humans | Neoplasm Proteins - physiology | HEK293 Cells | Mice | Liposomes | Mutation | Health aspects | Immunoproteins | Apoptosis | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2016, Volume 113, Issue 28, p. 7858
  Gasdermin-D (GsdmD) is a critical mediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yields an N-terminal... 
Membranes | Medical immunity | Bacteria | Mutation | Apoptosis
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 110 - 114
Journal Article
Science, ISSN 0036-8075, 10/2011, Volume 334, Issue 6054, pp. 376 - 380
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2012, Volume 109, Issue 24, p. 9378
Tank-binding kinase (TBK)1 plays a central role in innate immunity: it serves as an integrator of multiple signals induced by receptor-mediated pathogen... 
Enzymes | Immunology | Biochemistry | Autoimmune diseases | Binding sites | Cancer
Journal Article
Structure, ISSN 0969-2126, 11/2015, Volume 23, Issue 11, pp. 2043 - 2054
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 43, pp. 16803 - 16817
Journal Article