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Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2016, Volume 59, Issue 21, pp. 9622 - 9644
Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze... 
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 05/2018, Volume 25, Issue 5, pp. 384 - 393
Journal Article
Journal Article
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ISSN 0146-0404, 08/2019, Volume 60, Issue 10, pp. 3320 - 3331
PURPOSE. We previously identified an oxysterol, VP1-001 (also known as compound 29), that partially restores the transparency of lenses with cataracts. To... 
in vivo cataract model | DOCKING | ALPHA-B-CRYSTALLIN | POLYDISPERSITY | CHAPERONE | alpha B-crystallin | pharmacologic chaperone | MUTATION | enantiomer | OPHTHALMOLOGY | NUCLEAR CATARACT | PROTEINS | biophysical assay | MICROSCALE THERMOPHORESIS | STATE NMR | REVEALS | Lens | αB-crystallin
Journal Article
ACS chemical biology, ISSN 1554-8929, 11/2015, Volume 10, Issue 11, pp. 2441 - 2447
In drug discovery, small molecules must often discriminate between healthy and diseased cells. This feat is usually accomplished by binding to a protein that... 
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2018, Volume 26, Issue 19, pp. 5299 - 5306
Journal Article
Science, ISSN 0036-8075, 11/2015, Volume 350, Issue 6261, pp. 674 - 677
Cataracts reduce vision in 50% of individuals over 70 years of age and are a common form of blindness worldwide. Cataracts are caused when damage to the major... 
Causes of | Cataract | Care and treatment | Research | Cataracts | Proteins | Pharmacology | Visual impairment | Eyes & eyesight
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2015, Volume 56, Issue 45, pp. 6227 - 6230
The use of sodium in alumina and silica gels for the reductive cleavage of the N–O bond of -methoxy- -methylamides, commonly referred to as Weinreb amides, has... 
Alumina gel | Reduction | Silica gel | Weinreb amide | Sodium | KETONES | METHYLAMIDES | ALKALI-METALS | CHEMISTRY, ORGANIC | RUTHENIUM-CATALYZED REDUCTION | Amides | Silica | Aluminum oxide
Journal Article
01/2016, ISBN 1369587791
Peptidyl-prolyl isomerases (PPIases) are a ubiquitously expressed super family of proteins that catalyze the cis/trans isomerization of prolyl bonds. Proline... 
Biochemistry
Dissertation
Chemistry of Materials, ISSN 0897-4756, 05/2011, Volume 23, Issue 9, pp. 2388 - 2397
Liquid alkali metals and their alloys can be absorbed into the 15 nm diameter pores of nanostructured silica gel (SG) at loadings up to 40 wt %.... 
sodium | silicates | silicides | silica-gel | Na NMR | alkali metals | SELF-DIFFUSION | PARTICLES | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | SIMPLE GLASSES | REDUCTIONS | TEMPERATURE | REDUCING AGENT | AMORPHOUS SILICA | ZEOLITES | Na-23 NMR | INORGANIC ELECTRIDES
Journal Article
Cell Chemical Biology, ISSN 2451-9456, 05/2016, Volume 23, Issue 5, pp. 561 - 566
Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically, apratoxin A inhibits cotranslational... 
POTENT | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLODEPSIPEPTIDE | ER MEMBRANE | COTRANSLATIONAL TRANSLOCATION | ENDOPLASMIC-RETICULUM | MECHANISMS | Microbial toxins | Chemical properties | Health aspects | Membrane proteins
Journal Article
ChemInform, ISSN 0931-7597, 02/2016, Volume 47, Issue 9, pp. no - no
Sodium metal trapped in the nanoscale pores of alumina gel efficiently reduces Weinreb amides (I) in simple batch reaction mode. 
carboxylic amides (benzene compounds) | reduction, hydrogenation | Aluminum compounds | Amides | Silica
Journal Article
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