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science & technology (59) 59
life sciences & biomedicine (40) 40
peptides (31) 31
humans (30) 30
animals (24) 24
chemistry (20) 20
biochemistry & molecular biology (17) 17
models, molecular (14) 14
amino acid sequence (12) 12
peptides - chemistry (12) 12
pharmacology & pharmacy (12) 12
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multidisciplinary sciences (11) 11
binding sites (10) 10
proteins (10) 10
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chemistry, multidisciplinary (9) 9
metallurgy (9) 9
biochemistry (8) 8
microbiology (8) 8
native chemical ligation (8) 8
research (8) 8
beer (7) 7
enzymes (7) 7
enzymology (7) 7
mutation or genetic engineering (7) 7
organic chemistry (7) 7
peptides - chemical synthesis (7) 7
protein prenylation (7) 7
rab gtp-binding proteins - chemistry (7) 7
spirits (7) 7
vinegar (7) 7
wine (7) 7
chemistry, medicinal (6) 6
compositions thereof (6) 6
culture media (6) 6
fermentation or enzyme-using processes to synthesise a desiredchemical compound or composition or to separate optical isomersfrom a racemic mixture (6) 6
fluorescence (6) 6
kinetics (6) 6
microorganisms or enzymes (6) 6
molecular structure (6) 6
nuclear magnetic resonance--nmr (6) 6
peptide (6) 6
propagating, preserving or maintaining microorganisms (6) 6
protein binding (6) 6
protein folding (6) 6
structure-activity relationship (6) 6
toxins (6) 6
backbone (5) 5
biochemical research methods (5) 5
biological and medical sciences (5) 5
cell biology (5) 5
cells (5) 5
crystallography, x-ray (5) 5
female (5) 5
magnetic resonance spectroscopy (5) 5
male (5) 5
mice (5) 5
molecular sequence data (5) 5
peptides - pharmacology (5) 5
protein conformation (5) 5
rab gtp-binding proteins - chemical synthesis (5) 5
rab gtp-binding proteins - metabolism (5) 5
rats (5) 5
sodium channels (5) 5
solid‐phase synthesis (5) 5
analgesics (4) 4
biosynthesis (4) 4
cell line, tumor (4) 4
chemical synthesis (4) 4
cho cells (4) 4
chromatography, high pressure liquid (4) 4
conotoxins - chemistry (4) 4
cricetulus (4) 4
cyclotide (4) 4
disulfide mimetics (4) 4
dose-response relationship, drug (4) 4
fluorescent dyes - chemistry (4) 4
food science & technology (4) 4
fundamental and applied biological sciences. psychology (4) 4
gene expression (4) 4
hek293 cells (4) 4
immunology (4) 4
inhibitors (4) 4
life sciences (4) 4
mass spectrometry (4) 4
mutation (4) 4
pain (4) 4
patch-clamp techniques (4) 4
peptidomimetics (4) 4
protein structure, secondary (4) 4
solid-phase synthesis (4) 4
spider venoms - chemistry (4) 4
triazole bridges (4) 4
venom (4) 4
1.7 (3) 3
[sdv]life sciences [q-bio] (3) 3
asparaginyl endopeptidase (3) 3
binding sites - drug effects (3) 3
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1. Full Text The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
by Stunnenberg, Hendrik G and Abrignani, Sergio and Adams, David and de Almeida, Melanie and Altucci, Lucia and Amin, Viren and Amit, Ido and Antonarakis, Stylianos E and Aparicio, Samuel and Arima, Takahiro and Arrigoni, Laura and Arts, Rob and Asnafi, Vahid and Esteller, Manel and Bae, Jae-Bum and Bassler, Kevin and Beck, Stephan and Berkman, Benjamin and Bernstein, Bradley E and Bilenky, Mikhail and Bird, Adrian and Bock, Christoph and Boehm, Bernhard and Bourque, Guillaume and Breeze, Charles E and Brors, Benedikt and Bujold, David and Burren, Oliver and Bussemakers, Marion J and Butterworth, Adam and Campo, Elias and Carrillo-de-Santa-Pau, Enrique and Chadwick, Lisa and Chan, Kui Ming and Chen, Wei and Cheung, Tom H and Chiapperino, Luca and Choi, Nak Hyen and Chung, Ho-Ryun and Clarke, Laura and Connors, Joseph M and Cronet, Philippe and Danesh, John and Dermitzakis, Manolis and Drewes, Gerard and Durek, Pawel and Dyke, Stephanie and Dylag, Tomasz and Eaves, Connie J and Ebert, Peter and Eils, Roland and Eils, Jürgen and Ennis, Catherine A and Enver, Tariq and Feingold, Elise A and Felder, Bärbel and Ferguson-Smith, Anne and Fitzgibbon, Jude and Flicek, Paul and Foo, Roger S.-Y and Fraser, Peter and Frontini, Mattia and Furlong, Eileen and Gakkhar, Sitanshu and Gasparoni, Nina and Gasparoni, Gilles and Geschwind, Daniel H and Glažar, Petar and Graf, Thomas and Grosveld, Frank and Guan, Xin-Yuan and Guigo, Roderic and Gut, Ivo G and Hamann, Alf and Han, Bok-Ghee and Harris, R. Alan and Heath, Simon and Helin, Kristian and Hengstler, Jan G and Heravi-Moussavi, Alireza and Herrup, Karl and Hill, Steven and Hilton, Jason A and Hitz, Benjamin C and Horsthemke, Bernhard and Hu, Ming and Hwang, Joo-Yeon and Ip, Nancy Y and Ito, Takashi and Javierre, Biola-Maria and Jenko, Sasa and Jenuwein, Thomas and Joly, Yann and Jones, Steven J.M and Kanai, Yae and Kang, Hee Gyung and Karsan, Aly and Kiemer, Alexandra K and Kim, Song Cheol and Kim, Bong-Jo and ... and The International Human Epigenome Consortium and Int Human Epigenome Consortium and International Human Epigenome Consortium
Cell (Cambridge), ISSN 0092-8674, 11/2016, Volume 167, Issue 5, pp. 1145 - 1149
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | DNA Methylation | Epigenomics | Disease - genetics | Epigenesis, Genetic | Humans | Databases, Genetic | Histone Code | Genome, Human | Epigenetic inheritance | Cells | Web portals | Index Medicus | Epigenetics | ADN | Human genome | DNA | Genoma humà | Epigenètica
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2. Full Text Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development
by Durek, Pawel and Nordström, Karl and Gasparoni, Gilles and Salhab, Abdulrahman and Kressler, Christopher and de Almeida, Melanie and Bassler, Kevin and Ulas, Thomas and Schmidt, Florian and Xiong, Jieyi and Glažar, Petar and Klironomos, Filippos and Sinha, Anupam and Kinkley, Sarah and Yang, Xinyi and Arrigoni, Laura and Amirabad, Azim Dehghani and Ardakani, Fatemeh Behjati and Feuerbach, Lars and Gorka, Oliver and Ebert, Peter and Müller, Fabian and Li, Na and Frischbutter, Stefan and Schlickeiser, Stephan and Cendon, Carla and Fröhler, Sebastian and Felder, Bärbel and Gasparoni, Nina and Imbusch, Charles D and Hutter, Barbara and Zipprich, Gideon and Tauchmann, Yvonne and Reinke, Simon and Wassilew, Georgi and Hoffmann, Ute and Richter, Andreas S and Sieverling, Lina and Chang, Hyun-Dong and Syrbe, Uta and Kalus, Ulrich and Eils, Jürgen and Brors, Benedikt and Manke, Thomas and Ruland, Jürgen and Lengauer, Thomas and Rajewsky, Nikolaus and Chen, Wei and Dong, Jun and Sawitzki, Birgit and Chung, Ho-Ryun and Rosenstiel, Philip and Schulz, Marcel H and Schultze, Joachim L and Radbruch, Andreas and Walter, Jörn and Hamann, Alf and Polansky, Julia K and DEEP Consortium and Deep Consortium
Immunity (Cambridge, Mass.), ISSN 1074-7613, 11/2016, Volume 45, Issue 5, pp. 1148 - 1161
Life Sciences & Biomedicine | Immunology | Science & Technology | CD4-Positive T-Lymphocytes - immunology | Cell Differentiation - immunology | Flow Cytometry | Epigenomics - methods | Epigenesis, Genetic - immunology | Humans | Polymerase Chain Reaction | Transcriptome | Female | Gene Expression Profiling - methods | Machine Learning | Immunologic Memory - immunology | Studies | Consortia | Datasets | Cytokines | DNA methylation | Bone marrow | Epigenetics | Genomes | Gene expression | Deoxyribonucleic acid--DNA | Index Medicus
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3. Full Text High‐resolution microbiota flow cytometry reveals dynamic colitis‐associated changes in fecal bacterial composition
by Zimmermann, Jakob and Hübschmann, Thomas and Schattenberg, Florian and Schumann, Joachim and Durek, Pawel and Riedel, René and Friedrich, Marie and Glauben, Rainer and Siegmund, Britta and Radbruch, Andreas and Müller, Susann and Chang, Hyun‐Dong
European journal of immunology, ISSN 0014-2980, 05/2016, Volume 46, Issue 5, pp. 1300 - 1303
Flow cytometry | Microbiota | IBD | T‐cell transfer colitis | Single‐cell analysis | Single-cell analysis | T-cell transfer colitis | Life Sciences & Biomedicine | Immunology | Science & Technology | Flow Cytometry - methods | Humans | Gastrointestinal Microbiome | Phylogeny | Bacteria - genetics | Feces - microbiology | Bacteria - isolation & purification | Animals | Colitis - microbiology | Bacteria - cytology | Bacteria - classification | RNA, Ribosomal, 16S - genetics | Inflammatory Bowel Diseases - microbiology | Colitis | Microbiota (Symbiotic organisms) | T cells | Analysis | Inflammatory bowel disease | Index Medicus | Technical Comment
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4. Full Text NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency
by Harvey, Peta J and Kurniawan, Nyoman D and Finol-Urdaneta, Rocio K and McArthur, Jeffrey R and Van Lysebetten, Dorien and Dash, Thomas S and Hill, Justine M and Adams, David J and Durek, Thomas and Craik, David J
Molecules (Basel, Switzerland), ISSN 1420-3049, 10/2018, Volume 23, Issue 10, p. 2715
NMR | Voltage-gated sodium channel blocker | Protein structure | Μ-conotoxins | Peptides | Amino acids | Selectivity | Leucine | Crystallography | Channels | Magnetic resonance spectroscopy | Proteins | Spectrum analysis | Simulated annealing | Chemical bonds | Sodium channels (voltage-gated) | Polypeptides | Computer simulation | Muscles | Electrostatic properties | Skeletal muscle | Musculoskeletal system | Sodium | N-Terminus | Software | Toxins | NMR spectroscopy | Binding sites | Conotoxins | Conformation | Index Medicus | protein structure | μ-conotoxins | voltage-gated sodium channel blocker
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5. Full Text Preformed Selenoesters Enable Rapid Native Chemical Ligation at Intractable Sites
by Durek, Thomas and Alewood, Paul F
Angewandte Chemie (International ed.), ISSN 1433-7851, 12/2011, Volume 50, Issue 50, pp. 12042 - 12045
peptides | native chemical ligation | selenium | kinetics | synthetic methods | Selenium - chemistry | Peptides - chemical synthesis | Peptides - chemistry | Esters - chemistry | Molecular Structure | Kinetics | Organoselenium Compounds - chemistry | Peptides | Index Medicus
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6. Full Text Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant
by Bleackley, Mark R and Payne, Jennifer A. E and Hayes, Brigitte M. E and Durek, Thomas and Craik, David J and Shafee, Thomas M. A and Poon, Ivan K. H and Hulett, Mark D and Van Der Weerden, Nicole L and Anderson, Marilyn A
Antimicrobial agents and chemotherapy, ISSN 0066-4804, 10/2016, Volume 60, Issue 10, pp. 6302 - 6312
Pharmacology & Pharmacy | Life Sciences & Biomedicine | Microbiology | Science & Technology | Antifungal Agents - pharmacology | Defensins - metabolism | Drug Evaluation, Preclinical - methods | Defensins - genetics | Humans | Antineoplastic Agents, Phytogenic - chemistry | Fusarium - drug effects | Saccharomyces cerevisiae - drug effects | Antifungal Agents - chemistry | Recombinant Proteins - genetics | Defensins - chemistry | Permeability | Recombinant Proteins - pharmacology | Protein Folding | Saccharomyces cerevisiae - metabolism | Phosphatidylinositol 4,5-Diphosphate - metabolism | Defensins - pharmacology | Neomycin - pharmacology | Cell Line, Tumor | Tobacco - chemistry | Liposomes | Antineoplastic Agents, Phytogenic - pharmacology | Cell Membrane - drug effects | Index Medicus
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7. Full Text A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins
by Dash, Thomas S and Shafee, Thomas and Harvey, Peta J and Zhang, Chuchu and Peigneur, Steve and Deuis, Jennifer R and Vetter, Irina and Tytgat, Jan and Anderson, Marilyn A and Craik, David J and Durek, Thomas and Undheim, Eivind A.B
Structure (London), ISSN 0969-2126, 02/2019, Volume 27, Issue 2, pp. 315 - 326.e7
NMR | toxin | CSαβ fold | defensin | 3D structure | evolution | centipede | disulfide-rich peptide | Defensins - metabolism | Multigene Family | Humans | Xenopus laevis | Cells, Cultured | Arthropod Venoms - chemistry | Models, Molecular | Male | Arthropods - chemistry | Defensins - chemistry | Phylogeny | Arthropods - metabolism | Animals | Mice | Protein Stability | Arthropod Venoms - metabolism | Evolution, Molecular | Index Medicus
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8. Full Text Characterization of Synthetic Tf2 as a NaV1.3 Selective Pharmacological Probe
by Israel, Mathilde R and Dash, Thomas S and Bothe, Stefanie N and Robinson, Samuel D and Deuis, Jennifer R and Craik, David J and Lampert, Angelika and Vetter, Irina and Durek, Thomas
Biomedicines, ISSN 2227-9059, 06/2020, Volume 8, Issue 6, p. 155
Channel opening | Peptides | Venom | Excitability | Sodium channels (voltage-gated) | Diabetic neuropathy | Physiology | Toxins | Glucose | Injection | Neuropathy | Tf2 | NaV1.9 | NaV1.3 | sodium channel | toxin | scorpion
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9. Full Text Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase
by Harris, Karen S and Durek, Thomas and Kaas, Quentin and Poth, Aaron G and Gilding, Edward K and Conlan, Brendon F and Saska, Ivana and Daly, Norelle L and Van Der Weerden, Nicole L and Craik, David J and Anderson, Marilyn A
Nature communications, ISSN 2041-1723, 12/2015, Volume 6, Issue 1, pp. 10199 - 10199
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Cysteine Endopeptidases - metabolism | Peptides - metabolism | Cyclization | Magnetic Resonance Spectroscopy | Cysteine Endopeptidases - genetics | Mass Spectrometry | Oldenlandia | Gene Expression Profiling | Plant Proteins - metabolism | Recombinant Proteins | RNA, Messenger - metabolism | Index Medicus
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10. Full Text A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors
by Du, Junqiao and Yap, Kuok and Chan, Lai Yue and Rehm, Fabian B. H and Looi, Fong Yang and Poth, Aaron G and Gilding, Edward K and Kaas, Quentin and Durek, Thomas and Craik, David J
Nature communications, ISSN 2041-1723, 03/2020, Volume 11, Issue 1, pp. 1575 - 1575
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Backbone | Trypsin inhibitors | Angiogenesis | Biotechnology | Trypsin | Peptides | Precursors | Antiangiogenics | Endopeptidase | Biosynthesis | Plants | pH effects | Index Medicus
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11. Full Text A Centipede Toxin Family Defines an Ancient Class of CS[alpha][beta] Defensins
by Dash, Thomas S and Shafee, Thomas and Harvey, Peta J and Zhang, Chuchu and Peigneur, Steve and Deuis, Jennifer R and Vetter, Irina and Tytgat, Jan and Anderson, Marilyn A and Craik, David J and Durek, Thomas and Undheim, Eivind A.B
Structure (London), ISSN 0969-2126, 02/2019, Volume 27, Issue 2, p. 315
Cysteine | Peptides | Family
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12. Full Text Therapeutic conotoxins: a US patent literature survey
by Durek, Thomas and Craik, David J
Expert opinion on therapeutic patents, ISSN 1354-3776, 10/2015, Volume 25, Issue 10, pp. 1159 - 1173
pain | peptide | conopeptide | cone snail venom | drugs | ion channel | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Conotoxins - pharmacology | Animals | Ion Channels - metabolism | Pain - drug therapy | Humans | Drug Design | Patents as Topic | Conotoxins - chemistry | Index Medicus
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