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Nature, ISSN 0028-0836, 2016, Volume 538, Issue 7625, pp. 344 - 349
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether... 
IN-VITRO | TRANSFER-RNA SYNTHETASE | MALARIA CONTROL | PLASMODIUM-FALCIPARUM | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | LIVER | TARGETS | PROTEIN-SYNTHESIS | NEXT-GENERATION | HEPATIC STAGES | Azabicyclo Compounds - pharmacology | Plasmodium falciparum - enzymology | Malaria, Falciparum - prevention & control | Male | Plasmodium falciparum - cytology | Azetidines - pharmacology | Plasmodium falciparum - drug effects | Cytosol - enzymology | Malaria, Falciparum - transmission | Liver - drug effects | Azabicyclo Compounds - chemical synthesis | Azabicyclo Compounds - therapeutic use | Female | Safety | Antimalarials - chemical synthesis | Disease Models, Animal | Life Cycle Stages - drug effects | Malaria, Falciparum - drug therapy | Azabicyclo Compounds - administration & dosage | Azetidines - adverse effects | Phenylurea Compounds - therapeutic use | Antimalarials - therapeutic use | Macaca mulatta - parasitology | Phenylalanine-tRNA Ligase - antagonists & inhibitors | Drug Discovery | Antimalarials - pharmacology | Animals | Azetidines - administration & dosage | Phenylurea Compounds - chemical synthesis | Antimalarials - administration & dosage | Azetidines - therapeutic use | Phenylurea Compounds - administration & dosage | Mice | Phenylurea Compounds - pharmacology | Liver - parasitology | Plasmodium falciparum - growth & development | Prevention | Antimalarials | Disease transmission | Health aspects | Transfer RNA | Proteins | Cytochrome | Malaria | Liver | Parasites | Kinases | Drug resistance | Drug dosages
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2014, Volume 111, Issue 30, pp. 10911 - 10916
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 12/2016, Volume 12, Issue 12, pp. 1065 - 1074
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2015, Volume 10, Issue 3, p. e0120295
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2014, Volume 57, Issue 6, pp. 2746 - 2754
Journal Article
Organic Chemistry Frontiers, ISSN 2052-4110, 05/2014, Volume 1, Issue 3, pp. 303 - 320
Enantioselective allylation is a highly used organic reaction to prepare chiral homoallylic alcohols and amines, which serve as important building blocks in... 
SIMPLE ORGANIC-MOLECULES | ENANTIOSELECTIVE SYNTHESIS | DIASTEREOSELECTIVE SYNTHESIS | LEWIS-ACID | HOMOALLYLIC ALCOHOLS | ZINC AMIDE | CHEMISTRY, ORGANIC | CHIRAL BRONSTED ACID | STEREOSELECTIVE-SYNTHESIS | FORCE-FIELD MODEL | QUATERNARY CARBON
Journal Article
Cephalalgia, ISSN 0333-1024, 12/2019, Volume 39, Issue 14, pp. 1847 - 1854
Objective Cerebrospinal fluid-venous fistula is an uncommon cause of spontaneous spinal cerebrospinal fluid leak (SSCSFL). We aim to describe the clinical... 
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 07/2013, Volume 135, Issue 26, pp. 9675 - 9680
The Hedgehog signaling pathway is involved in the development of multicellular organisms and, when deregulated, can contribute to certain cancers, among other... 
TRANSLOCATION | SUPPRESSOR | CELLS | SIGNALING PATHWAY | INHIBITORS | MUTATIONS | ANTAGONISTS | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Sonic hedgehog | Research | Structure-activity relationships (Biochemistry) | Deregulation | Analogies | Inhibitors | Pathways | Sonics | Strategy | Organisms | Modulators
Journal Article
Diversity and Distributions, ISSN 1366-9516, 11/2012, Volume 18, Issue 11/12, pp. 1077 - 1091
Journal Article
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 10/2006, Volume 71, Issue 22, pp. 8579 - 8590
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2010, Volume 132, Issue 47, pp. 16962 - 16976
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 04/2015, Volume 211, Issue 7, pp. 1097 - 1103
Background. The emergence and spread of drug resistance to current antimalarial therapies remains a pressing concern, escalating the need for compounds that... 
drug development | drug resistance | malaria | diversity-oriented synthesis | target identification | cytochrome b | INFECTIOUS DISEASES | BC INHIBITORS | DRUG DISCOVERY | VALIDATION | MICROBIOLOGY | IMMUNOLOGY | MALARIA PARASITES | ATOVAQUONE | DATABASE | RESISTANCE | CHEMISTRY | QI SITE | MOLECULAR-BASIS | Plasmodium falciparum - enzymology | Protozoan Proteins - antagonists & inhibitors | Humans | Molecular Sequence Data | Ubiquinone - metabolism | Drug Discovery - methods | Plasmodium falciparum - drug effects | Enzyme Inhibitors - chemical synthesis | Protozoan Proteins - genetics | Cytochromes b - chemistry | Lactams, Macrocyclic - chemistry | Cytochromes b - antagonists & inhibitors | Phenylurea Compounds - chemistry | Base Sequence | Enzyme Inhibitors - chemistry | Lactams, Macrocyclic - chemical synthesis | Plasmodium falciparum - genetics | Protozoan Proteins - chemistry | Antimalarials - chemical synthesis | Drug Resistance | Malaria, Falciparum - drug therapy | Catalytic Domain | Oxidation-Reduction | Enzyme Inhibitors - pharmacology | Lactams, Macrocyclic - pharmacology | Antimalarials - pharmacology | Drug Synergism | Malaria, Falciparum - parasitology | High-Throughput Screening Assays | Phenylurea Compounds - chemical synthesis | Cytochromes b - genetics | Small Molecule Libraries | Antimalarials - chemistry | High-Throughput Nucleotide Sequencing | Phenylurea Compounds - pharmacology | Cytochrome b | Research | Drug resistance | Health aspects | Major and Brief Reports
Journal Article