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Chemical Society Reviews, ISSN 0306-0012, 2/2016, Volume 45, Issue 3, pp. 546 - 576
The advent of modern C-H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage functionalization (LSF),... 
IRIDIUM-CATALYZED BORYLATION | HYDROGEN ISOTOPE-EXCHANGE | HIGH-THROUGHPUT EXPERIMENTATION | COPPER-MEDIATED FLUORINATION | C-H BOND | AEROBIC OXIDATIVE HYDROXYLATION | CRYSTALLINE SPONGE METHOD | JAK2 INHIBITOR LY2784544 | CHEMISTRY, MULTIDISCIPLINARY | ARYLBORONIC ACIDS | PHOTOREDOX CATALYSIS | Drugs | Hot spots | Chemists | Blocking | Tools | Strategy | Biology | Bioactive
Journal Article
CHEMICAL SOCIETY REVIEWS, ISSN 0306-0012, 3/2017, Volume 46, Issue 6, pp. 176 - 176
Correction for 'The medicinal chemist's toolbox for late stage functionalization of drug-like molecules' by Tim Cernak et al. , Chem. Soc. Rev. , 2016, 45 ,... 
CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 03/2017, Volume 46, Issue 6, p. 1760
Journal Article
Chemical Society reviews, ISSN 0306-0012, 02/2016, Volume 45, Issue 3, pp. 546 - 576
The advent of modern C-H functionalization chemistries has enabled medicinal chemists to consider a synthetic strategy, late stage functionalization (LSF),... 
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2016, Volume 81, Issue 16, pp. 6980 - 6987
We report the development of a method for room-temperature C–H hydroxymethylation of heteroarenes. A key enabling advance in this work was achieved by... 
CHEMISTRY, ORGANIC | ETHERS | C-H FUNCTIONALIZATION | DERIVATIVES | Oxidation-reduction reaction | Usage | Catalysis | Methylation
Journal Article
Chemical Science, ISSN 2041-6520, 04/2016, Volume 7, Issue 4, pp. 2604 - 2613
Major new advances in synthetic chemistry methods are typically reported using simple, non-standardized reaction substrates, and reaction failures are rarely... 
REACTION DISCOVERY | BORONIC ACIDS | CROSS-COUPLING REACTIONS | ROBUSTNESS SCREEN | HETEROCYCLIC CARBENE COMPLEXES | PALLADIUM PRECATALYST | RAPID ASSESSMENT | C-H BORYLATION | CHEMISTRY, MULTIDISCIPLINARY | SUZUKI-MIYAURA | ARYL CHLORIDES | Visualization | Collection | Chemical reactions | Evolution | Libraries | Diagnostic systems | Failure | Principal component analysis
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 06/2015, Volume 55, Issue 6, p. 1130
  We report the development and implementation of a cheminformatics tool which aids in the design of compounds during exploratory chemistry and lead... 
Molecular structure | Chemists | Biochemistry | Chemical synthesis | Bioinformatics
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2019, Volume 29, Issue 10, pp. 1182 - 1186
Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of... 
Inhibitor | DGAT1 | [3.1.0] bicyclohexane carboxylic acid | Benzimidazole | Isomerization | IBUPROFEN | POTENT | CHEMISTRY, MEDICINAL | CHEMISTRY, ORGANIC | CHIRAL INVERSION | DISCOVERY | Lead compounds | Metabolites | Cyclohexane
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 06/2015, Volume 55, Issue 6, pp. 1130 - 1135
Journal Article
Chemical Science, ISSN 2041-6520, 4/2016, Volume 7, Issue 4, pp. 2604 - 2613
We report a standardized complex molecule diagnostic approach using collections of relevant drug-like molecules which we call chemistry informer libraries.... 
Chemistry
Journal Article
ISSN 2041-6520, 3/2016, Volume 7, Issue 4, pp. 264 - 2613
Major new advances in synthetic chemistry methods are typically reported using simple, non-standardized reaction substrates, and reaction failures are rarely... 
Journal Article
Chem. Sci, ISSN 2041-6520, 2016, Volume 7, Issue 4, pp. 2604 - 2613
Major new advances in synthetic chemistry methods are typically reported using simple, non-standardized reaction substrates, and reaction failures are rarely... 
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2007, Volume 17, Issue 8, pp. 2322 - 2328
A novel class of indole ligands for estrogen receptor α have been discovered which exhibit potent affinity and high selectivity. Substitution of the... 
Estrogen receptor | SERAMs | ERα | 2-Aryl indoles | CHEMISTRY, MEDICINAL | ANTIESTROGENS | estrogen receptor | CHEMICAL-SHIFTS | SAR | DIHYDROBENZOXATHIIN SERAMS | MODULATORS | CHEMISTRY, ORGANIC | DISCOVERY | SIDE-CHAINS | POTENT | SERMS | 2-aryl indoles | MULTIFUNCTIONAL MEDICINES | ER alpha
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2004, Volume 14, Issue 6, pp. 1417 - 1421
A class of flavanoids exhibiting a high degree of selectivity for ERα over ERβ has been discovered. The most active analogue 6 was found to be 66-fold... 
SERMs | Flavanoids | CHEMISTRY, MEDICINAL | ANTIESTROGENS | ANALOGS | MODULATORS | CHEMISTRY, ORGANIC | flavanoids | ANTAGONISM | DERIVATIVES | MULTIFUNCTIONAL MEDICINES | ISOFLAVANONE | Receptors, Estrogen - metabolism | Animals | Stereoisomerism | Flavonoids - metabolism | Humans | Uterus - metabolism | Rats | Female | Flavonoids - chemistry | Rats, Sprague-Dawley | Protein Binding - physiology
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 1998, Volume 39, Issue 14, pp. 1865 - 1868
The Stille cross-coupling reaction is an extremely mild and versatile method for the coupling of organostannanes with vinyl triflates. This methodology has... 
HALIDES | CEPHALOSPORIN CHEMISTRY | CHEMISTRY, ORGANIC | PALLADIUM | CARBAPENEM ANTIBIOTICS | ORGANOSTANNANES
Journal Article
ChemInform, ISSN 0931-7597, 03/2016, Volume 47, Issue 13, pp. no - no
Journal Article
Bioorganic & medicinal chemistry letters, ISSN 0960-894X, 04/2007, Volume 17, Issue 8, p. 2322
A novel class of indole ligands for estrogen receptor alpha have been discovered which exhibit potent affinity and high selectivity. Substitution of the... 
Humans | Uterus - drug effects | Cell Line, Tumor | Estrogen Antagonists - chemistry | Inhibitory Concentration 50 | Estrogen Antagonists - pharmacology | Estrogen Receptor alpha - antagonists & inhibitors | Female | Indoles - pharmacokinetics | Ligands | Breast Neoplasms - drug therapy | Indoles - chemistry
Journal Article
TETRAHEDRON LETTERS, ISSN 0040-4039, 11/2011, Volume 52, Issue 48, pp. 6457 - 6459
The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro(5.5]undecan-9-yl)acetate are described. (C) 2011 Elsevier Ltd. All... 
GROWTH-HORMONE SECRETAGOGUES | DESIGN | HYDROGENATION | CHEMISTRY, ORGANIC | Log D | AGONISTS | DISCOVERY | Ring closing metathesis | POTENT | Spiropiperidine | OPTIMIZATION | ANTAGONISTS | Lipophilicity | Analogs | Tetrahedrons | Strategy | Synthesis (chemistry)
Journal Article
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