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Nature, ISSN 0028-0836, 01/2019, Volume 565, Issue 7738, pp. 165 - 166
A computational strategy has delivered a redesigned, more stable version of a cytokine protein that mimics the natural protein's interactions with receptors,... 
Computational biology and bioinformatics | Immunology | Cancer | INTERLEUKIN-2 | COMPLEX | IL-2 | MULTIDISCIPLINARY SCIENCES | Physiological aspects | Protein engineering | Interleukin-2 | Immunotherapy | Methods
Journal Article
Nature, ISSN 0028-0836, 01/2019, Volume 565, Issue 7738, pp. 165 - 166
In the immune system, a cytokine called interleukin-2 (IL-2) delivers signals to receptors that regulate the activities of white blood cells. Excitingly, this... 
Animal models | Cytokines | Toxicity | Blood cells | Interleukin | Reengineering | Erythrocytes | Leukocytes | Redesign | Proteins | White blood cells | Design | Engineering | Receptors | Colon cancer | Interleukin 2 | Skin | Colon | Cancer | Immune system
Journal Article
Nature communications, ISSN 2041-1723, 08/2019, Volume 10, Issue 1, pp. 3691 - 12
Semaphorin ligands and their plexin receptors are one of the major cell guidance factors that trigger localised changes in the cytoskeleton. Binding of... 
REFINEMENT | SYSTEM | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PLEXIN | RESOLUTION | OFF-TRACK | RECEPTOR | SECRETED SEMAPHORINS | EFFICIENT | Signaling | Receptors | Oligomerization | Insects | Semaphorins | Drosophila | Crosstalk | Cytoskeleton | Dimers | Tuning | Crystal structure
Journal Article
Philosophical Transactions: Mathematical, Physical and Engineering Sciences, ISSN 1364-503X, 3/2015, Volume 373, Issue 2036, pp. 1 - 11
The cell-to-cell signalling mechanisms of multicellular organisms orchestrate human development during embryogenesis and control homeostasis in adult tissues.... 
Journal Article
Journal Article