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Cell Reports, ISSN 2211-1247, 06/2013, Volume 3, Issue 6, pp. 1777 - 1784
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2018, Volume 378, Issue 8, pp. 731 - 739
Journal Article
The Lancet Oncology, ISSN 1470-2045, 05/2018, Volume 19, Issue 5, pp. 705 - 714
Gene fusions involving , or (TRK fusions) are found in a broad range of paediatric and adult malignancies. Larotrectinib, a highly selective small-molecule... 
ONCOLOGY | INFANTILE FIBROSARCOMA | MOLECULAR-DETECTION | RESPONSE ASSESSMENT | ACQUIRED-RESISTANCE | CONGENITAL FIBROSARCOMA | QUALITY-OF-LIFE | KINASE INHIBITOR LOXO-101 | TROPOMYOSIN | SOFT-TISSUE SARCOMA | MESOBLASTIC NEPHROMA | Age Factors | Discoidin Domain Receptor 2 - antagonists & inhibitors | United States | Humans | Receptor, trkA - antagonists & inhibitors | Child, Preschool | Infant | Male | Receptor, trkB - genetics | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Young Adult | Membrane Glycoproteins - antagonists & inhibitors | Neoplasms - genetics | Time Factors | Antineoplastic Agents - adverse effects | Receptor, trkB - antagonists & inhibitors | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Biomarkers, Tumor - antagonists & inhibitors | Child | Discoidin Domain Receptor 2 - genetics | Pyrazoles - adverse effects | Drug Administration Schedule | Administration, Oral | Pyrimidines - administration & dosage | Gene Fusion | Treatment Outcome | Membrane Glycoproteins - genetics | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Pyrazoles - administration & dosage | Receptor Protein-Tyrosine Kinases - genetics | Adolescent | Pyrimidines - adverse effects | Receptor, trkA - genetics | Biomarkers, Tumor - genetics | Neoplasms - pathology | Genetic research | Pediatrics | Analysis
Journal Article
Journal Article
Journal Article
Cell Reports, 03/2013, Volume 3, Issue 6, pp. 1777 - 1784
Developmental regulatory genes have both activating (H3K4me3) and repressive (H3K27me3) histone modifications in embryonic stem cells (ESCs). This bivalent... 
Journal Article
Journal Article
Biology of Reproduction, ISSN 0006-3363, 01/2006, Volume 74, Issue 1, pp. 119 - 124
Journal Article
Cancer Discovery, ISSN 2159-8274, 09/2017, Volume 7, Issue 9, pp. 963 - 972
Journal Article
Blood, ISSN 0006-4971, 08/2018, Volume 132, Issue 8, pp. 861 - 865
Publisher's Note: There is a Blood Commentary on this article in this issue. 
PH-LIKE | ONCOGENE | KINASE | LINE | GENE FUSION | HEMATOLOGY | CANCER | CARCINOMA | EVENT | ETV6 | Letter to
Journal Article
NATURE MEDICINE, ISSN 1078-8956, 09/2019, Volume 25, Issue 9, pp. 1422 - 1422
TRK fusions are found in a variety of cancer types, lead to oncogenic addiction, and strongly predict tumor-agnostic efficacy of TRK inhibition(1-8). With the... 
TARGETED THERAPY | MEDICINE, RESEARCH & EXPERIMENTAL | FUSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACQUIRED-RESISTANCE | BRAF | MECHANISMS | EGFR | CELL BIOLOGY | AMPLIFICATION | ENTRECTINIB | CRIZOTINIB | MUTATIONS
Journal Article