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1. Full Text Sentryn and SAD Kinase Link the Guided Transport and Capture of Dense Core Vesicles in Caenorhabditis elegans
by Morrison, Logan M and Edwards, Stacey L and Manning, Laura and Stec, Natalia and Richmond, Janet E and Miller, Kenneth G and Miller, Kenneth G
Genetics, ISSN 0016-6731, 11/2018, Volume 210, Issue 3, pp. 925 - 946
Dense core vesicles (DCVs) can transmit signals by releasing neuropeptides from specialized synaptic regions called active zones. DCVs reach the active zone by... 
axonal transport | Liprin | dense core vesicle | Sentryn | SAD kinase | SCAFFOLDING PROTEIN | PRESYNAPTIC ACTIVE ZONE | RIM-BINDING PROTEINS | LIPRIN-ALPHA | NEUROTRANSMITTER RELEASE | AXONAL-TRANSPORT | POLARIZED TRAFFICKING | GENETICS & HEREDITY | SYNAPTIC SIGNALING NETWORK | C-ELEGANS | CARBOXYPEPTIDASE-E | Dyneins - metabolism | Animals | Caenorhabditis elegans - cytology | Caenorhabditis elegans - metabolism | Biological Transport | Caenorhabditis elegans - genetics | Secretory Vesicles - metabolism | Axons - metabolism | Caenorhabditis elegans Proteins - metabolism | Mutation | Caenorhabditis elegans - enzymology | Protein-Serine-Threonine Kinases - metabolism | Proteins | Vesicles | Neurons | Nematodes | Motors | Neuropeptides | Geographical variations | Transport | Interrupts | Axonal transport | Cell body | Dense core vesicles | Investigations
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2. Full Text Sentryn Acts with a Subset of Active Zone Proteins To Optimize the Localization of Synaptic Vesicles in Caenorhabditis elegans
by Edwards, Stacey L and Morrison, Logan M and Manning, Laura and Stec, Natalia and Richmond, Janet E and Miller, Kenneth G and Miller, Kenneth G
Genetics, ISSN 0016-6731, 11/2018, Volume 210, Issue 3, pp. 947 - 968
Synaptic vesicles (SVs) transmit signals by releasing neurotransmitters from specialized synaptic regions of neurons. In the synaptic region, SVs are tightly... 
axonal transport | Liprin | Sentryn | SAD kinase | synaptic vesicle | NERVOUS-SYSTEM | LIPRIN-ALPHA | POLARIZED TRAFFICKING | UNC-16 JIP3 | TRANSPORT | GENETICS & HEREDITY | G-ALPHA(S) PATHWAY | ASSEMBLY PROTEINS | SYD-1 | C-ELEGANS | DENSE-CORE VESICLES | Dyneins - metabolism | Dendrites - metabolism | Synaptic Vesicles - metabolism | Animals | Caenorhabditis elegans - cytology | Caenorhabditis elegans - metabolism | Lysosomes - metabolism | Caenorhabditis elegans - genetics | Axons - metabolism | Caenorhabditis elegans Proteins - metabolism | Mutation | Protein Transport | Enrichment | Neurons | Lysosomes | Motors | Kinases | Accumulation | Proteins | Axons | Neurotransmitters | Vesicles | Genetic analysis | Dynein | Nematodes | Synaptic vesicles | Dendrites | Transport | Position (location) | Localization | Axonal transport | Worms | Synapses | Investigations
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3. Full Text Local microtubule organization promotes cargo transport in C. elegans dendrites
by Harterink, Martin and Edwards, Stacey L and de Haan, Bart and Yau, Kah Wai and van den Heuvel, Sander and Kapitein, Lukas C and Miller, Kenneth G and Miller, Kenneth G and Hoogenraad, Casper C and Hoogenraad, Casper C
Journal of cell science, ISSN 0021-9533, 10/2018, Volume 131, Issue 20, p. jcs223107
The specific organization of the neuronal microtubule cytoskeleton in axons and dendrites is an evolutionarily conserved determinant of neuronal polarity that... 
Polarity | C. elegans | Microtubule | Dendrite | MTOC | PLUS-END | PROTEIN | DYNEIN | AXON | CELL BIOLOGY | SOLUBLE GUANYLATE CYCLASES | POSTMITOTIC NEURONS | ORIENTATION | DIFFERENTIATION | EXPRESSION
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4. Full Text Beyond GWASs: Illuminating the Dark Road from Association to Function
by Edwards, Stacey L and Beesley, Jonathan and French, Juliet D and Dunning, Alison M
The American Journal of Human Genetics, ISSN 0002-9297, 11/2013, Volume 93, Issue 5, pp. 779 - 797
Genome-wide association studies (GWASs) have enabled the discovery of common genetic variation contributing to normal and pathological traits and clinical drug... 
LONG-RANGE INTERACTION | LINKAGE DISEQUILIBRIUM | DNA METHYLATION | BREAST-CANCER RISK | CYCLIN D1 EXPRESSION | COLORECTAL-CANCER | GENETICS & HEREDITY | SUSCEPTIBILITY LOCI | CHRONIC LYMPHOCYTIC-LEUKEMIA | HUMAN GENE-EXPRESSION | GENOME-WIDE ASSOCIATION | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Epigenesis, Genetic | Humans | Risk Factors | Computational Biology | Chromosome Mapping | Genetic Loci | RNA, Untranslated - genetics | Phenotype | Animals | Neoplasms - genetics | Polymorphism, Single Nucleotide | Neoplasms - pathology | Genetic variation | Genome-wide association studies | Research | Review
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5. Full Text Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
by Edwards, Stacey L and Charlie, Nicole K and Richmond, Janet E and Hegermann, Jan and Eimer, Stefan and Miller, Kenneth G
Journal of Cell Biology, ISSN 0021-9525, 09/2009, Volume 186, Issue 6, pp. 881 - 895
Despite a key role for dense core vesicles (DCVs) in neuronal function, there are major gaps in our understanding of DCV biogenesis. A genetic screen for... 
SECRETORY GRANULE BIOGENESIS | NEUROTROPHIC FACTOR | APOPTOTIC CELLS | G-ALPHA(S) PATHWAY | SYNAPTIC SIGNALING NETWORK | GENE FAMILY | C-ELEGANS | UNC-31 CAPS | MASS-SPECTROMETRY | NERVE GROWTH-FACTOR | CELL BIOLOGY | Synaptic Vesicles - metabolism | Phosphatidylinositol Phosphates - metabolism | Evoked Potentials | rab GTP-Binding Proteins - genetics | rab2 GTP-Binding Protein - deficiency | Neurons - ultrastructure | Excitatory Postsynaptic Potentials | Secretory Vesicles - enzymology | rab GTP-Binding Proteins - deficiency | GTP-Binding Protein alpha Subunits - metabolism | Caenorhabditis elegans - genetics | Secretory Vesicles - ultrastructure | Axons - metabolism | Synapses - enzymology | Genotype | Neuropeptides - metabolism | Protein Transport | Caenorhabditis elegans - ultrastructure | Locomotion | Phenotype | Animals | Miniature Postsynaptic Potentials | Neurons - enzymology | rab2 GTP-Binding Protein - genetics | Muscles - innervation | Endosomes - enzymology | Mutation | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Physiological aspects | Caenorhabditis elegans | Genetic aspects | Cell organelles | Research | Gene mutations
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6. Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework
by Justin G Teeguarden and Yu-Mei Tan and Stephen W Edwards and Jeremy A Leonard and Kim A Anderson and Richard A Corley and Molly L Kile and Staci M Simonich and David Stone and Robert L Tanguay and Katrina M Waters and Stacey L Harper and David E Williams
Environmental Science & Technology, ISSN 0013-936X, 05/2016, Volume 50, Issue 9, p. 4579
  Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health,... 
Toxicology | Environmental science | Decision making | Risk assessment | Human exposure
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7. Full Text Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework
by Teeguarden, Justin G and Tan, Yu-Mei and Edwards, Stephen W and Leonard, Jeremy A and Anderson, Kim A and Corley, Richard A and Kile, Molly L and Simonich, Staci M and Stone, David and Tanguay, Robert L and Waters, Katrina M and Harper, Stacey L and Williams, David E and Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Environmental Science and Technology, ISSN 0013-936X, 05/2016, Volume 50, Issue 9
Driven by major scientific advances in analytical methods, biomonitoring, and computational exposure assessment, and a newly articulated vision for a greater... 
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8. Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework
by Teeguarden, Justin G and Tan, Yu-Mei and Edwards, Stephen W and Leonard, Jeremy A and Anderson, Kim A and Corley, Richard A and Kile, Molly L and Simonich, Staci M and Stone, David and Tanguay, Robert L and Waters, Katrina M and Harper, Stacey L and Williams, David E
Environmental Science & Technology, ISSN 0013-936X, 05/2016, Volume 50, Issue 9, pp. 4579 - 4579
Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health,... 
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9. Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport in Caenorhabditis elegans
by Edwards, Stacey L and Yorks, Rosalina M and Morrison, Logan M and Hoover, Christopher M and Miller, Kenneth G
Genetics, ISSN 0016-6731, 09/2015, Volume 201, Issue 1, pp. 91 - 91
The functional integrity of neurons requires the bidirectional active transport of synaptic vesicles (SVs) in axons. The kinesin motor KIF1A transports SVs... 
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10. Full Text Synapse-Assembly Proteins Maintain Synaptic Vesicle Cluster Stability and Regulate Synaptic Vesicle Transport inCaenorhabditis elegans
by Edwards, Stacey L and Yorks, Rosalina M and Morrison, Logan M and Hoover, Christopher M and Miller, Kenneth G
Genetics, ISSN 0016-6731, 09/2015, Volume 201, Issue 1, pp. 91 - 116
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11. Full Text MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer
by Milevskiy, Michael J.G and Sandhu, Gurveen K and Wronski, Anna and Korbie, Darren and Brewster, Brooke L and Shewan, Annette and Edwards, Stacey L and French, Juliet D and Brown, Melissa A
Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 71, pp. 33577 - 33588
Depletion of BRCA1 protein in mouse mammary glands results in defects in lactational development and increased susceptibility to mammary cancer. Extensive work... 
Biomarker | BRCA1 | Breast Cancer | MiRNA
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12. UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles to Caenorhabditis elegans Motor Neuron Axons
by Edwards, Stacey L and Morrison, Logan M and Yorks, Rosalina M and Hoover, Christopher M and Boominathan, Soorajnath and Miller, Kenneth G
Genetics, ISSN 0016-6731, 09/2015, Volume 201, Issue 1, pp. 117 - 117
The conserved protein UNC-16 (JIP3) inhibits the active transport of some cell soma organelles, such as lysosomes, early endosomes, and Golgi, to the synaptic... 
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13. Full Text UNC-16 (JIP3) Acts Through Synapse-Assembly Proteins to Inhibit the Active Transport of Cell Soma Organelles toCaenorhabditis elegansMotor Neuron Axons
by Edwards, Stacey L and Morrison, Logan M and Yorks, Rosalina M and Hoover, Christopher M and Boominathan, Soorajnath and Miller, Kenneth G
Genetics, ISSN 0016-6731, 09/2015, Volume 201, Issue 1, pp. 117 - 141
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14. Full Text A common variant at the 14q32 endometrial cancer risk locus activates AKT1 through YY1 binding
by Painter, Jodie N and Kaufmann, Susanne and O'Mara, Tracy A and Hillman, Kristine M and Sivakumaran, Haran and Darabi, Hatef and Cheng, Timothy H.T and Pearson, John and Kazakoff, Stephen and Waddell, Nicola and Hoivik, Erling A and Goode, Ellen L and Scott, Rodney J and Tomlinson, Ian and Dunning, Alison M and Easton, Douglas F and French, Juliet D and Salvesen, Helga B and Pollock, Pamela M and Thompson, Deborah J and Spurdle, Amanda B and Edwards, Stacey L
American Journal of Human Genetics, ISSN 0002-9297, 06/2016, Volume 98, Issue 6, p. 1159
A recent meta-analysis of multiple genome-wide association and follow-up endometrial cancer case-control datasets identified a novel genetic risk locus for... 
Genetic aspects | Endometrial cancer | Genetic variation | Health aspects | Binding sites (Biochemistry)
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15. Full Text Abstract 1980: Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability
by Milevskiy, Michael J and Al-Ejeh, Fares and Saunus, Jodi M and Northwood, Korinne S and McCart-Reed, Amy E and Dray, Eloise and Nephew, Kenneth and Bailey, Peter J and Betts, Joshua A and Stone, Andrew and Gee, Julia M W and Shewan, Annette M and French, Juliet D and Edwards, Stacey L and Clark, Susan J and Lakhani, Sunil R and Brown, Melissa A
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 1980 - 1980
Long-range regulators of gene expression are emerging as promising new biomarkers and therapeutic targets for human diseases including cancer. As current... 
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16. Beyond GWASs: Illuminating the Dark Road from Association to Function
by Stacey L Edwards and Jonathan Beesley and Juliet D French and Alison M Dunning
American Journal of Human Genetics, ISSN 0002-9297, 11/2013, Volume 93, Issue 5, p. 779
  Genome-wide association studies (GWASs) have enabled the discovery of common genetic variation contributing to normal and pathological traits and clinical... 
Biological variation | Genes | Epigenetics | Genomes | Ribonucleic acid--RNA | Epidemiology | Bioinformatics
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17. Full Text A Novel CaM Kinase II Pathway Controls the Location of Neuropeptide Release fromCaenorhabditis elegansMotor Neurons
by Hoover, Christopher M and Edwards, Stacey L and Yu, Szi-chieh and Kittelmann, Maike and Richmond, Janet E and Eimer, Stefan and Yorks, Rosalina M and Miller, Kenneth G
Genetics, ISSN 0016-6731, 03/2014, Volume 196, Issue 3, pp. 745 - 765
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18. An Organelle Gatekeeper Function for Caenorhabditis elegans UNC-16 (JIP3) at the Axon Initial Segment
by Edwards, Stacey L and Yu, Szi-chieh and Hoover, Christopher M and Phillips, Barret C and Richmond, Janet E and Miller, Kenneth G
Genetics, ISSN 0016-6731, 05/2013, Volume 194, Issue 1, pp. 143 - 143
Neurons must cope with extreme membrane trafficking demands to produce axons with organelle compositions that differ dramatically from those of the cell soma... 
Active transport
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19. Full Text Association analysis identifies 65 new breast cancer risk loci
by Michailidou, Kyriaki and Lindström, Sara and Dennis, Joe and Beesley, Jonathan and Hui, Shirley and Kar, Siddhartha and Lemaçon, Auey and Soucy, Penny and Glubb, Dylan and Rostamianfar, Asha and Bolla, Manjeet K and Wang, Qin and Tyrer, Jonathan and Dicks, Ed and Lee, Anew and Wang, Zhaoming and Allen, Jamie and Keeman, Renske and Eilber, Ursula and French, Juliet D and Qing Chen, Xiao and Fachal, Laura and McCue, Karen and McCart Reed, Amy E and Ghoussaini, Maya and Carroll, Jason S and Jiang, Xia and Finucane, Hilary and Adams, Marcia and Adank, Muriel A and Ahsan, Habibul and Aittomäki, Kristiina and Anton-Culver, Hoda and Antonenkova, Natalia N and Arndt, Volker and Aronson, Kristan J and Arun, Banu and Auer, Paul L and Bacot, François and Barrdahl, Myrto and Baynes, Caroline and Beckmann, Matthias W and Behrens, Sabine and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Blomqvist, Carl and Bogdanova, Natalia V and Bojesen, Stig E and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Brand, Judith S and Brauch, Hiltrud and Brennan, Paul and Brenner, Hermann and Brinton, Louise and Broberg, Per and Brock, Ian W and Broeks, Annegien and Brooks-Wilson, Angela and Brucker, Sara Y and Brüning, Thomas and Burwinkel, Barbara and Butterbach, Katja and Cai, Qiuyin and Cai, Hui and Caldés, Trinidad and Canzian, Federico and Carracedo, Angel and Carter, Brian D and Castelao, Jose E and Chan, Tsun L and David Cheng, Ting-Yuan and Seng Chia, Kee and Choi, Ji-Yeob and Christiansen, Hans and Clarke, Christine L and Collée, Margriet and Conroy, Don M and Cordina-Duverger, Emilie and Cornelissen, Sten and Cox, David G and Cox, Angela and Cross, Simon S and Cunningham, Julie M and Czene, Kamila and Daly, Mary B and Devilee, Peter and Doheny, Kimberly F and Dörk, Thilo and Dos-Santos-Silva, Isabel and Dumont, Martine and Durcan, Lorraine and Dwek, Miriam and Eccles, Diana M and Ekici, Arif B and Eliassen, A. Heather and Ellberg, Carolina and Elvira, Mingajeva and Engel, Christoph and ... and KConFab AOCS Investigators and ABCTB Investigators and NBCS Collaborators and ConFab/AOCS Investigators and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Ortopedi and Uppsala universitet and Institutionen för kirurgiska vetenskaper
Nature, ISSN 0028-0836, 2017, Volume 551, Issue 7678, pp. 92 - 94
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of... 
COMPREHENSIVE MOLECULAR PORTRAITS | PROTEIN | ANNOTATION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | ARCHITECTURE | PATHWAY ANALYSIS | MUTATIONS | ENHANCERS | EXPRESSION | GENOME-WIDE ASSOCIATION | Multifactorial Inheritance - genetics | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Risk Assessment | Humans | Regulatory Sequences, Nucleic Acid | Asia - ethnology | Asian Continental Ancestry Group - genetics | Binding Sites - genetics | Genetic Loci | Europe - ethnology | Transcription Factors - metabolism | Breast Neoplasms - genetics | Computer Simulation | Polymorphism, Single Nucleotide - genetics | Female | Breast Neoplasms - diagnosis | Quantitative trait loci | Breast cancer | Genetic aspects | Health aspects | Risk factors | Medical research | Transcription factors | BRCA1 protein | Genes | Health risks | Association analysis | Risk | Genomes | Biology | Single-nucleotide polymorphism | Regulatory sequences | Epidemiology | Loci | Medicine | Womens health | Breast | Genetics | Heritability | Health risk assessment | Binding sites | Tumors | Cancer | Medical and Health Sciences | Medicin och hälsovetenskap
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20. Full Text Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
by Bojesen, Stig E and Pooley, Karen A and Johnatty, Sharon E and Beesley, Jonathan and Michailidou, Kyriaki and Tyrer, Jonathan P and Edwards, Stacey L and Pickett, Hilda A and Shen, Howard C and Smart, Chanel E and Hillman, Kristine M and Mai, Phuong L and Lawrenson, Kate and Stutz, Michael D and Lu, Yi and Karevan, Rod and Woods, Nicholas and Johnston, Rebecca L and French, Juliet D and Chen, Xiaoqing and Weischer, Maren and Nielsen, Sune F and Maranian, Melanie J and Ghoussaini, Maya and Ahmed, Shahana and Baynes, Caroline and Bolla, Manjeet K and Wang, Qin and