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Aging Cell, ISSN 1474-9718, 12/2012, Volume 11, Issue 6, pp. 996 - 1004
Summary In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive... 
senescence | aging | brain | inflammation | neurons | oxidative stress | Aging | Brain | Oxidative stress | Senescence | Inflammation | Neurons | HUMAN-CELLS | TRIGGERS SENESCENCE | DIETARY RESTRICTION | P16(INK4A) | CELLULAR SENESCENCE | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | MITOCHONDRIAL DYSFUNCTION | MICE | ONSET | TELOMERES | Myenteric Plexus - pathology | Reactive Oxygen Species - metabolism | Caloric Restriction | Mitosis | Cell Count | Humans | Myenteric Plexus - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - deficiency | RNA - genetics | Telomerase - deficiency | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Telomerase - genetics | Aging - genetics | Gene Expression Regulation, Developmental | beta-Galactosidase - metabolism | DNA Damage - genetics | Telomere - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Interleukin-6 - metabolism | Telomere - genetics | Cellular Senescence - genetics | Purkinje Cells - metabolism | Interleukin-6 - genetics | Signal Transduction | Mice, Inbred C57BL | p38 Mitogen-Activated Protein Kinases - genetics | Aging - pathology | Phenotype | Telomere - pathology | Animals | Mice | beta-Galactosidase - genetics | Purkinje Cells - pathology | Aging - metabolism | Immunohistochemistry | Peptides | Developmental biology | DNA damage | DNA repair | Interleukins | DNA | Genetic aspects | Universities and colleges | Chromosomes | Telomerase | Genotype & phenotype | Original
Journal Article
New Biotechnology, ISSN 1871-6784, 09/2017, Volume 38, Issue Part A, p. 36
We have determined the putative anti-ageing properties of Khelma Longevity™, a formula based on various natural compounds from the Mediterranean area. Human... 
Proteins | Carbonyl compounds | Properties (attributes) | Aging | Fibroblasts | Biomarkers | Lipids | Aging (natural) | Longevity | Carbonyls
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 12/2016, Volume 25, Issue 16, pp. 855 - 869
Journal Article
Free radical biology & medicine, ISSN 0891-5849, 10/2014, Volume 75 Suppl 1, p. S18
Collapse of proteostasis and accumulation of damaged macromolecules have been recognized as hallmarks of aging and age-related diseases. The proteasome is the... 
Caenorhabditis elegans | Proteases | Proteolysis | Analysis
Journal Article
Aging Cell, ISSN 1474-9718, 04/2013, Volume 12, Issue 2, pp. 184 - 193
Journal Article
Aging Cell, ISSN 1474-9718, 06/2014, Volume 13, Issue 3, pp. 401 - 407
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 1, pp. 224 - 230
Protein synthesis and degradation balance have a crucial role in maintenance of cellular homeostasis and function. The ubiquitin-proteasome system is one of... 
Hsp90 | Proteasome activation | Hsp70 | Proteasome | Protein synthesis inhibition
Journal Article
Aging Cell, ISSN 1474-9718, 08/2016, Volume 15, Issue 4, pp. 755 - 765
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2013, Volume 65, pp. S5 - S5
Journal Article
European Journal of Endocrinology, ISSN 0804-4643, 06/2017, Volume 176, Issue 6, p. R283
Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent,... 
Molecular modelling | Life span | Complications | Pituitary | Homeostasis | Aging | Hypothalamus | Longevity | Endocrinology | Environmental effects | Quality of life | Geriatrics
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 05/2018, Volume 9, Issue MAY, p. 457
Aging is a multifactorial process characterized by the accumulation of proteins undergoing oxidative modifications, either due to enhanced levels of oxidative... 
Anti-oxidants | Nutrition | Proteolysis | Aging | Frailty | Inflammation | Proteasome | proteasome | OXIDATIVE STRESS | ACTIVATION | PHYSIOLOGY | PROTEOTOXICITY | PERSPECTIVE | IMMUNOPROTEASOME | MECHANISMS | frailty | nutrition | inflammation | anti-oxidants | DISEASE | RESISTANCE | HUMAN FIBROBLASTS | aging | HEALTH | proteolysis | Care and treatment | Aged | Health aspects
Journal Article
Oxidative Medicine and Cellular Longevity, ISSN 1942-0900, 2017, Volume 2017, pp. 1401452 - 12
Journal Article